Daypro Side Effects

Generic name: oxaprozin

Medically reviewed by Drugs.com. Last updated on Nov 26, 2022.

Note: This document contains side effect information about oxaprozin. Some dosage forms listed on this page may not apply to the brand name Daypro.

Summary

More frequent side effects include: constipation, diarrhea, dyspepsia, nausea, and skin rash. Continue reading for a comprehensive list of adverse effects.

Applies to oxaprozin: oral tablet.

Serious side effects of Daypro

Along with its needed effects, oxaprozin (the active ingredient contained in Daypro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxaprozin:

More common

• Skin rash

Less common

• Bloating
• bloody or black, tarry stools
• burning upper abdominal or stomach pain
• burning while urinating
• cloudy urine
• constipation
• decrease in urine output or decrease in urine-concentrating ability
• diarrhea
• difficult or painful urination
• frequent urination
• headache
• heartburn
• indigestion
• itching skin
• loss of appetite
• nausea or vomiting
• pale skin
• severe stomach pain, cramping, or burning
• severe and continuing nausea
• swelling
• trouble breathing
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting of blood or material that looks like coffee grounds
• weight loss

Incidence not known

• Agitation
• bleeding gums
• blistering, peeling, or loosening of the skin
• blurred vision
• body aches or pain
• burning feeling in chest or stomach
• changes in blood pressure
• chest pain or tightness
• clay-colored stools
• coma
• confusion
• cough or hoarseness
• cracks in the skin
• dark urine
• depression
• difficult or labored breathing
• difficulty swallowing
• dilated neck veins
• dizziness
• ear congestion
• extreme fatigue
• fainting
• feeling of discomfort
• fever or chills
• fluid-filled skin blisters
• high fever
• hives or welts
• hostility
• increased sensitivity of the skin to sunlight
• increased thirst
• increased volume of pale, dilute urine
• inflammation of the joints
• irregular, fast or slow, or shallow breathing
• joint or muscle pain
• large, flat, blue or purplish patches in the skin
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• lethargy
• light-colored stools
• lightheadedness
• loss of heat from the body
• loss of voice
• lower back or side pain
• muscle aches
• muscle twitching
• noisy breathing
• pain or burning in the throat
• pain or tenderness around the eyes and cheekbones
• pale or blue lips, fingernails, or skin
• pinpoint red or purple spots on the skin
• pounding in the ears
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rapid weight gain
• red skin lesions, often with a purple center
• red, irritated eyes
• redness or other discoloration of the skin
• redness, swelling, or soreness of tongue
• scaly skin
• seizures
• severe sunburn
• skin thinness
• slow, fast, irregular, pounding, or racing heartbeat or pulse
• sneezing
• sore throat
• sores, ulcers, or white spots on the lips or tongue or inside the mouth
• stuffy or runny nose
• stupor
• swelling of the face, fingers, feet, or lower legs
• swelling or inflammation of the mouth
• swollen lymph glands
• tenderness in the stomach area
• unpleasant breath odor
• upper right abdominal or stomach pain
• yellow eyes or skin

Other side effects of Daypro

Some side effects of oxaprozin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Acid or sour stomach
• belching
• stomach discomfort

Less common

• Continuing ringing or buzzing or other unexplained noise in the ears
• excess air or gas in the stomach or intestines
• hearing loss
• passing gas
• relaxed and calm
• sleepiness or unusual drowsiness
• trouble sleeping

Rare

• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• burning, dry, or itching eyes
• change in taste
• decreased hearing
• discharge, excessive tearing
• dry mouth
• feeling of constant movement of self or surroundings
• general feeling of discomfort or illness
• lack or loss of strength
• redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
• sensation of spinning
• shakiness in the legs, arms, hands, feet
• trembling or shaking of the hands or feet

For Healthcare Professionals

Applies to oxaprozin: oral tablet.

General

The most frequently reported adverse effects were gastrointestinal (GI) in nature and included GI pain, anorexia, GI ulcers, heartburn, dyspepsia, nausea, vomiting, diarrhea, constipation, flatulence, and gross bleeding or perforation.^[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain/distress, anorexia, constipation, diarrhea, dyspepsia, flatulence, gastrointestinal (GI) ulcers, gross bleeding/perforation, heartburn, nausea, vomiting

Frequency not reported: Dry mouth, eructation, esophagitis, gastritis, glossitis, hematemesis, stomatitis, pancreatitis, hemorrhoid bleeding, rectal bleeding, melena^[Ref]

Hepatic

Common (1% to 10%): Liver enzymes elevated

Frequency not reported: Jaundice, liver function abnormalities, hepatitis, liver failure^[Ref]

Renal

Common (1% to 10%): Abnormal renal function

Frequency not reported: Acute interstitial nephritis, cystitis, renal insufficiency, acute renal failure, nephrotic syndrome, renal calculi^[Ref]

Cardiovascular

Frequency not reported: Arrhythmia, blood pressure changes, congestive heart failure, hypertension, hypotension, myocardial infarction, palpitations, tachycardia, syncope, vasculitis^[Ref]

Nervous system

Common (1% to 10%): CNS inhibition, somnolence, sedation, dizziness, headache

Frequency not reported: Taste disturbance, coma, convulsions, drowsiness, paresthesia, tremors^[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash

Frequency not reported: Ecchymosis, purpura, alopecia, angioedema, urticaria, photosensitivity, pseudoporphyria, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, sweating, toxic epidermal necrolysis^[Ref]

Hematologic

Common (1% to 10%): Anemia, bleeding time increased

Frequency not reported: Agranulocytosis, aplastic anemia, eosinophilia, hemolytic anemia, lymphadenopathy, pancytopenia, thrombocytopenia, leukopenia^[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions^[Ref]

Other

Common (1% to 10%): Edema, tinnitus

Frequency not reported: Death, sepsis, fever, infection, asthenia, malaise, meningitis, vertigo, weakness, hearing decreased^[Ref]

Psychiatric

Common (1% to 10%): Depression, confusion, sleep disturbance, dream abnormalities

Frequency not reported: Anxiety, hallucinations, insomnia, nervousness^[Ref]

Genitourinary

Common (1% to 10%): Dysuria, urinary frequency

Frequency not reported: Hematuria, menstrual flow increased, oliguria, polyuria, proteinuria, menstrual flow decreased^[Ref]

Respiratory

Frequency not reported: Asthma, dyspnea, pulmonary infections, pneumonia, sinusitis, upper respiratory tract infection, respiratory depression^[Ref]

Immunologic

Frequency not reported: Serum sickness^[Ref]

Metabolic

Frequency not reported: Appetite changes, hyperglycemia, weight changes^[Ref]

Ocular

Frequency not reported: Blurred vision, conjunctivitis^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer