Daypro Side Effects

Generic name: oxaprozin

Medically reviewed by Drugs.com. Last updated on Mar 10, 2025.

Note: This document provides detailed information about Daypro Side Effects associated with oxaprozin. Some dosage forms listed on this page may not apply specifically to the brand name Daypro.

Applies to oxaprozin: oral capsule, oral tablet.

Precautions

It is very important that your doctor check your or your child's progress at regular visits while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to use it. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk. Check with your doctor right away if you or your child has chest pain that may spread to your arms, jaw, back, or neck, trouble breathing or speaking, headache, nausea, unusual sweating, or faintness.

This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (eg, steroid or a blood thinner).

Check with your doctor right away if you or your child has pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

If you are rapidly gaining weight, trouble breathing, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of heart problems or your body keeping too much water.

Serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) can occur with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, fever, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots on the lips or in the mouth, swollen glands, unusual bleeding or bruising, or unusual tiredness and weakness. .

Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, or lower legs, severe stomach pain, black, tarry stools, or vomiting of blood or material that looks like coffee grounds, unusual weight gain, yellow skin or eyes, decreased urination, unusual bleeding or bruising, or skin rash. Also, signs of serious heart problems could occur including chest pain or tightness, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Check with your doctor immediately if you notice any of these warning signs.

Check with your doctor right away if you have blood in the urine, decrease in the frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These may be symptoms of a serious kidney problem.

This medicine may cause a serious allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Your blood pressure might get too high while you are using this medicine. This may cause headaches, dizziness, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high, call your doctor right away.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs.

Using this medicine during the later part of a pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

Before having any kind of surgery or medical tests, tell your doctor that you are using this medicine. It may be necessary for you to stop treatment for a while, or to change to a different medicine before your procedure.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Daypro

Along with its needed effects, oxaprozin (the active ingredient contained in Daypro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxaprozin:

Other side effects of Daypro

Some side effects of oxaprozin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to oxaprozin: oral capsule, oral tablet.

General adverse events

The most frequently reported adverse effects were gastrointestinal (GI) in nature and included GI pain, anorexia, GI ulcers, heartburn, dyspepsia, nausea, vomiting, diarrhea, constipation, flatulence, and gross bleeding or perforation.^[Ref]

Gastrointestinal

• Common (1% to 10%): Abdominal pain/distress, anorexia, constipation, diarrhea, dyspepsia, flatulence, gastrointestinal (GI) ulcers, gross bleeding/perforation, heartburn, nausea, vomiting
• Frequency not reported: Dry mouth, eructation, esophagitis, gastritis, glossitis, hematemesis, stomatitis, pancreatitis, hemorrhoid bleeding, rectal bleeding, melena^[Ref]

Hepatic

• Common (1% to 10%): Liver enzymes elevated
• Frequency not reported: Jaundice, liver function abnormalities, hepatitis, liver failure^[Ref]

Renal

• Common (1% to 10%): Abnormal renal function
• Frequency not reported: Acute interstitial nephritis, cystitis, renal insufficiency, acute renal failure, nephrotic syndrome, renal calculi^[Ref]

Cardiovascular

• Frequency not reported: Arrhythmia, blood pressure changes, congestive heart failure, hypertension, hypotension, myocardial infarction, palpitations, tachycardia, syncope, vasculitis^[Ref]

Nervous system

• Common (1% to 10%): CNS inhibition, somnolence, sedation, dizziness, headache
• Frequency not reported: Taste disturbance, coma, convulsions, drowsiness, paresthesia, tremors^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus, rash
• Frequency not reported: Ecchymosis, purpura, alopecia, angioedema, urticaria, photosensitivity, pseudoporphyria, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, sweating, toxic epidermal necrolysis^[Ref]

Hematologic

• Common (1% to 10%): Anemia, bleeding time increased
• Frequency not reported: Agranulocytosis, aplastic anemia, eosinophilia, hemolytic anemia, lymphadenopathy, pancytopenia, thrombocytopenia, leukopenia^[Ref]

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions^[Ref]

Other

• Common (1% to 10%): Edema, tinnitus
• Frequency not reported: Death, sepsis, fever, infection, asthenia, malaise, meningitis, vertigo, weakness, hearing decreased^[Ref]

Psychiatric

• Common (1% to 10%): Depression, confusion, sleep disturbance, dream abnormalities
• Frequency not reported: Anxiety, hallucinations, insomnia, nervousness^[Ref]

Genitourinary

• Common (1% to 10%): Dysuria, urinary frequency
• Frequency not reported: Hematuria, menstrual flow increased, oliguria, polyuria, proteinuria, menstrual flow decreased^[Ref]

Respiratory

• Frequency not reported: Asthma, dyspnea, pulmonary infections, pneumonia, sinusitis, upper respiratory tract infection, respiratory depression^[Ref]

Immunologic

• Frequency not reported: Serum sickness^[Ref]

Metabolic

• Frequency not reported: Appetite changes, hyperglycemia, weight changes^[Ref]

Ocular

• Frequency not reported: Blurred vision, conjunctivitis^[Ref]

See also:

Further information

Daypro side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer