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Cometriq Side Effects

Generic Name: cabozantinib

Note: This page contains information about the side effects of cabozantinib. Some of the dosage forms included on this document may not apply to the brand name Cometriq.

For the Consumer

Applies to cabozantinib: oral capsule

In addition to its needed effects, some unwanted effects may be caused by cabozantinib (the active ingredient contained in Cometriq). In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking cabozantinib:

More common:
  • Blurred vision
  • burning, numbness, tingling, or painful sensations
  • dehydration
  • difficulty with breathing or swallowing
  • dizziness
  • headache
  • nervousness
  • pain in the chest, groin, or legs, especially the calves
  • pounding in the ears
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • severe, sudden headache
  • skin ulcers
  • slow or fast heartbeat
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • tingling of the hands and feet
  • unsteadiness or awkwardness
  • vision changes
  • weakness in the arms, hands, legs, or feet
Less common:
  • Bleeding gums
  • bloody, black, or tarry stools
  • coughing up blood
  • heartburn
  • heavy jaw feeling
  • increased menstrual flow or vaginal bleeding
  • indigestion
  • loosening of a tooth
  • nausea
  • nosebleeds
  • pain, swelling, or numbness in the mouth or jaw
  • paralysis
  • prolonged bleeding from cuts
  • red or dark brown urine
  • severe abdominal or stomach pain, cramping, or burning
  • trouble breathing
  • vomiting of material that looks like coffee grounds, severe and continuing
Rare:
  • Confusion
  • disturbed color perception
  • double vision
  • halos around lights
  • night blindness
  • overbright appearance of lights
  • seizures
  • tunnel vision

Severity: Minor

Some of the side effects that can occur with cabozantinib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • belching
  • bleeding after defecation
  • change in taste
  • changes in hair color
  • decreased appetite
  • decreased weight
  • diarrhea
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dry skin
  • fear
  • hair loss or thinning of the hair
  • hoarseness
  • lack or loss of strength
  • loss of taste
  • muscle pain or stiffness
  • muscle spasm
  • pain in the joints
  • rash
  • sore throat
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • uncomfortable swelling around the anus
  • voice changes
  • vomiting

For Healthcare Professionals

Applies to cabozantinib: oral capsule, oral tablet

Cardiovascular

Very common (10% or more): Elevated blood pressure (up to 96%), hypertension (up to 61%)
Common (1% to 10%): Hypotension, venous thromboembolism, arterial thromboembolism, atrial fibrillation
Uncommon (0.1% to 1%): Angina pectoris, supraventricular tachycardia, shortened activated partial thromboplastin time
Frequency not reported: QT interval prolongation[Ref]

Hepatic

Very common (10% or more): Increased ALT (up to 86%), increased AST (up to 86%), increased alkaline phosphatase (up to 52%), hyperbilirubinemia (up to 25%)
Common (1% to 10%): Cholelithiasis
Uncommon (0.1% to 1%): Hepatic encephalopathy[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 63%), stomatitis (up to 51%), nausea (up to 43%), oral pain (up to 36%), constipation (up to 27%), abdominal pain (up to 27%), vomiting (up to 24%), dysphagia (up to 13%), dyspepsia (up to 11%), glossodynia
Common (1% to 10%): Hemorrhoids, GI perforation, GI fistula, GI hemorrhage, pancreatitis, anal fissure, anal inflammation, cheilitis
Uncommon (0.1% to 1%): Esophagitis[Ref]

Endocrine

Very common (10% or more): Increased blood thyroid stimulating hormone (up to 57%)
Common (1% to 10%): Hypothyroidism
Uncommon (0.1% to 1%): Amenorrhea[Ref]

Hematologic

Very common (10% or more): Lymphopenia (up to 53%), neutropenia (up to 35%), thrombocytopenia (up to 35%)
Uncommon (0.1% to 1%): Increased eosinophil count, increased platelet count[Ref]

Dermatologic

Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (up to 50%), hair color changes/depigmentation/graying (up to 34%), rash (up to 19%), dry skin (up to 19%), alopecia (up to 16%), erythema (up to 11%)
Common (1% to 10%): Hyperkeratosis, folliculitis, acne, blister, abnormal hair growth, skin exfoliation, skin hypopigmentation
Uncommon (0.1% to 1%): Skin ulcer, telangiectasia[Ref]

Metabolic

Very common (10% or more): Decreased weight (up to 48%), decreased appetite (up to 46%), hypocalcemia (up to 52%), hypophosphatemia (up to 28%), hypomagnesemia (up to 19%), hypokalemia (up to 18%), hyponatremia (up to 10%), increased blood lactate dehydrogenase, increased blood creatinine phosphokinase
Common (1% to 10%): Dehydration, hypoalbuminemia[Ref]

Other

Very common (10% or more): Fatigue (up to 41%), asthenia (up to 21%), mucosal inflammation
Common (1% to 10%): Abscess (including visceral, intra-abdominal, skin, tooth), fungal infection (including skin, oral, genital), ear pain, tinnitus, pallor, peripheral coldness, impaired wound healing/wound complications, chills, face edema
Uncommon (0.1% to 1%): Aspergilloma, hypoacusis, cyst, facial pain, localized edema
Frequency not reported: Hemorrhage[Ref]

Nervous system

Very common (10% or more): Dysgeusia (up to 34%), headache (up to 18%), dizziness (up to 14%)
Common (1% to 10%): Paresthesia, peripheral sensory neuropathy, peripheral neuropathy, ageusia, tremor
Uncommon (0.1% to 1%): Reversible posterior leukoencephalopathy syndrome, ataxia, attention disturbance, loss of consciousness, speech disorder, transient ischemic attack[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (up to 14%), muscle spasms (up to 12%)
Common (1% to 10%): Musculoskeletal chest pain, osteonecrosis of the jaw
Uncommon (0.1% to 1%): Rhabdomyolysis[Ref]

General

Patients should be closely monitored for the first 8 weeks as most adverse events have occurred early in the course of treatment.[Ref]

Genitourinary

Common (1% to 10%): Proteinuria, dysuria, hematuria
Uncommon (0.1% to 1%): Vaginal hemorrhage[Ref]

Ocular

Common (1% to 10%): Blurred vision
Uncommon (0.1% to 1%): Cataract, conjunctivitis[Ref]

Psychiatric

Common (1% to 10%): Anxiety, depression, confusional state
Uncommon (0.1% to 1%): Abnormal dreams, delirium[Ref]

Respiratory

Very common (10% or more): Dysphonia (up to 20%),oropharyngeal pain
Common (1% to 10%): Non-GI fistula (including tracheal, pneumomediastinum, tracheo-esophageal), pulmonary embolism, respiratory tract hemorrhage (including pulmonary, bronchial, tracheal), pneumonia, pneumonia aspiration
Uncommon (0.1% to 1%): Atelectasis, pharyngeal edema, pneumonitis[Ref]

Renal

Uncommon (0.1% to 1%): Acute renal failure[Ref]

References

1. "Product Information. Cometriq (cabozantinib)." Exelixis Inc, S San Francisco, CA.

Not all side effects for Cometriq may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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