Generic Name: lenvatinib (len VA ti nib)
Brand Names: Lenvima
What is Lenvima?
Lenvima (lenvatinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Lenvima is used to treat thyroid cancer.
Lenvima is usually given after radioactive iodine has been tried without success.
Lenvima is also used together with everolimus (Afinitor) for the treatment of patients with advanced advanced kidney cancer who have been previously treated with an anti-angiogenic therapy.
Some people taking Lenvima have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines. Get emergency medical help if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
Call your doctor at once if you have signs of serious side effects, including: severe chest pain, shortness of breath, swelling in your ankles, numbness or weakness, confusion, severe headache, problems with speech or vision, seizure (convulsions), unusual bleeding, coughing up blood, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Before taking this medicine
You should not use Lenvima if you are allergic to lenvatinib, or if you have:
uncontrolled high blood pressure;
congestive heart failure;
a heart rhythm disorder;
personal or family history of long QT syndrome; or
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
To make sure Lenvima is safe for you, tell your doctor if you have:
high blood pressure;
headaches or vision problems;
a history of perforation (a hole or tear) in your stomach or intestines;
a seizure disorder; or
a history of heart attack, heart failure, stroke, or blood clot.
Do not use Lenvima if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your treatment ends.
Lenvima may affect fertility (your ability to have children), whether you are a man or a woman.
It is not known whether lenvatinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I take Lenvima?
Lenvatinib is usually taken once per day. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
You may take Lenvima with or without food. Take the medicine at the same time each day.
To get a full dose, you may need to take a combination of Lenvima capsules with different amounts (strengths) of medicine in them. Follow your doctor's dosing instructions very carefully.
Do not crush, chew, break, or open the Lenvima capsules. Swallow the capsules whole
To make swallowing easier, you may dissolve the capsules in water as follows:
Measure 1 tablespoon of water or apple juice and pour the liquid into a small glass.
Place the capsules (whole, not crushed or broken) into the liquid. Use only enough capsules for one dose.
Allow the capsules to dissolve in the liquid for at least 10 minutes. Then, stir the mixture for at least 3 more minutes.
Swallow the mixture right away without chewing. Do not save it for later use.
To make sure you get the entire dose, add 1 more tablespoon of liquid to the same glass, swirl gently and drink right away.
Call your doctor if you are sick with vomiting or diarrhea. Prolonged illness can lead to dehydration and kidney failure while you are taking Lenvima.
Lenvima is usually given until your body no longer responds to the medication.
While using Lenvima, you will need frequent blood and urine tests. Your blood pressure will need to be checked often.
Store at room temperature away from moisture and heat.
Lenvima dosing information
Usual Adult Dose of Lenvima for Thyroid Cancer:
24 mg orally once a day
Duration of therapy: Until disease progression or unacceptable toxicity occurs
Use: Treatment of patient with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Lenvima?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Lenvima side effects
Get emergency medical help if you have signs of an allergic reaction to Lenvima: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some people taking Lenvima have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
Also call your doctor at once if you have:
severe headache, vision problems, weakness, confusion, seizure (convulsions);
easy bruising, unusual bleeding (nosebleeds, bleeding gums), heavy menstrual bleeding, or any other bleeding that will not stop;
signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
heart problems - shortness of breath (even with mild exertion), swelling in your ankles, rapid weight gain, chest pain or pressure, pain spreading to your jaw or shoulder;
symptoms of a blood clot - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
low calcium levels - numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes;
kidney problems - little or no urinating, painful or difficult urination, pain in your lower back; or
dangerously high blood pressure - pounding in your neck or ears, nosebleed, anxiety, severe chest pain, irregular heartbeats.
Common Lenvima side effects may include:
stomach pain, nausea, vomiting, diarrhea;
loss of appetite, weight loss;
muscle or joint pain;
rash, redness, itching, or peeling on the palms of your hands or the soles of your feet;
headache, tiredness; or
cough, hoarse voice.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Lenvima?
Lenvima can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Lenvima.
This list is not complete. Other drugs may interact with lenvatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Lenvima (lenvatinib)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Lenvima.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lenvima only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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