Generic Name: trametinib (tra ME ti nib)
Brand Name: Mekinist
What is trametinib?
Trametinib is used alone or in combination with another medicine called dabrafenib (Tafinlar) to treat certain types of cancer in people who have a "BRAF" gene mutation. These medicines are for use in treating:
melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body, or to prevent melanoma from coming back after surgery;
non-small cell lung cancer that has spread to other parts of the body; or
advanced or metastatic thyroid cancer that has spread and for which there are no other treatment options.
Trametinib may also be used for purposes not listed in this medication guide.
Using trametinib with dabrafenib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms.
Before taking this medicine
Tell your doctor if you have ever had:
heart disease, high blood pressure;
liver or kidney disease;
a stomach or intestinal disorder;
eye problems (especially a problem with your retina); or
bleeding problems, or a blood clot.
Using trametinib with dabrafenib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.
Trametinib can harm an unborn baby or cause birth defects if the mother or the father is using trametinib.
If you are a woman, do not use trametinib if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant, even if you have had a vasectomy. Keep using birth control for at least 4 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using trametinib.
This medicine may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because trametinib can harm an unborn baby.
You should not breastfeed while using this medicine, and for at least 4 months after your last dose.
How should I take trametinib?
Trametinib is used only if your cancer has a specific genetic marker (an abnormal "BRAF" gene). Your doctor will test you for this gene.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take trametinib on an empty stomach, at least 1 hour before or 2 hours after a meal.
Your doctor will need to check your skin every 2 months while you are using trametinib, and for up to 6 months after your last dose.
Your blood pressure and heart function will need to be checked often. You may also need regular vision examinations.
You may be given steroid medication if you have a fever and severe chills for 3 days or longer. Keep using the steroid for as long as your doctor has prescribed.
Store in the refrigerator and protect from light. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. Do not store trametinib tablets in a pill box.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking trametinib?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Trametinib side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects are more likely to occur if you take trametinib and dabrafenib together. Call your doctor at once if you have:
cough, feeling short of breath;
fever, chills, feeling light-headed;
little or no urination;
increased thirst or urination;
eye pain or swelling, vision changes, seeing halos around lights, seeing color "dots" in your vision;
signs of bleeding--weakness, dizziness, headache, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
signs of a blood clot--chest pain, sudden cough or trouble breathing, pain or swelling in an arm or leg, pale skin, cold feeling in an arm or leg; or
signs of a heart problem--shortness of breath (even with mild exertion), pounding heartbeats, swelling in your feet or ankles.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
nausea, vomiting, diarrhea, loss of appetite;
fever, chills, tiredness;
increased blood pressure;
muscle or joint pain;
cough, shortness of breath;
swelling in your arms, face, and legs; or
rash, dry skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect trametinib?
Other drugs may affect trametinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 7.01.
More about trametinib
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- En Español
- 1 Review
- Drug class: multikinase inhibitors
Other brands: Mekinist