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Trametinib Side Effects

In Summary

Commonly reported side effects of trametinib include: acneiform eruption, cardiomyopathy, decreased left ventricular ejection fraction, dermatitis, palmar-plantar erythrodysesthesia, skin rash, and erythema. Other side effects include: cardiac failure. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to trametinib: oral tablet

As well as its needed effects, trametinib may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking trametinib, check with your doctor immediately:

More common:
  • Bleeding from the rectum or bloody stools
  • bleeding gums
  • blemishes on the skin
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody nose
  • blurred vision
  • chest discomfort or pain
  • cracked, dry, or scaly skin
  • decreased urine output
  • diarrhea
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • faintness
  • fast, slow, irregular, or pounding heartbeat
  • headache
  • irregular breathing
  • irregular heartbeat
  • lightheadedness, dizziness, or fainting
  • nervousness
  • pimples
  • pounding in the ears
  • rapid weight gain
  • rash
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • shortness of breath
  • tightness in the chest
  • tingling of the hands and feet
  • troubled breathing
  • ulceration of the skin
  • unusual tiredness or weakness
  • unusual weight gain or loss
Less common:
  • Cough
  • fever
Rare
  • Change in vision
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain across part of your vision

Minor Side Effects

Some trametinib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abdominal or stomach pain
  • burning, itching, and pain in hairy areas, pus at the root of the hair
  • canker sores
  • change in taste
  • dark-colored urine
  • dry eyes
  • dry mouth
  • dry skin
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • loosening of the fingernails
  • loss of taste
  • muscle cramps or spasms
  • muscle pain or stiffness
  • redness or soreness around the fingernails
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • swelling or inflammation of the mouth
  • thirst

For Healthcare Professionals

Applies to trametinib: oral tablet

General

Rash and decreased LVEF were the most common reasons cited for dose reductions of trametinib.

The most common adverse reactions resulting in permanent discontinuation of trametinib were decreased left ventricular ejection fraction (LVEF), pneumonitis, renal failure, diarrhea, and rash.[Ref]

Cardiovascular

Very common (10% or more): Lymphedema (43%), hypertension (15%), hemorrhage (13%)
Frequency not reported: Bradycardia[Ref]

Dermatologic

Very common (10% or more): rash (57%), dermatitis acneiform (19%), dry skin (11%), pruritus (10%), paronychia (10%)
Frequency not reported: Folliculitis, rash pustular, cellulitis[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (43%), stomatitis (15%), abdominal pain (13%)
Frequency not reported: Xerostomia[Ref]

Hematologic

Very common (10% or more): Anemia (38%)[Ref]

Hepatic

Very common (10% or more): Increased aspartate aminotransferase (AST) (60%), Increased alanine aminotransferase (ALT) (39%)[Ref]

Metabolic

Very common (10% or more): Hypoalbuminemia (42%), increased alkaline phosphatase (24%)[Ref]

Musculoskeletal

Frequency not reported: Rhabdomyolysis[Ref]

Nervous system

Frequency not reported: Dizziness, dysgeusia[Ref]

Ocular

Frequency not reported: Vision blurred, dry eye[Ref]

References

1. "Product Information. Mekinist (trametinib)." GlaxoSmithKline, Research Triangle Park, NC.

It is possible that some side effects of trametinib may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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