Generic Name: trametinib (tra ME ti nib)
Brand Names: Mekinist
Medically reviewed on September 5, 2017.
What is Mekinist?
Mekinist is also used with dabrafenib to treat a certain type of non-small cell lung cancer that has spread to other parts of the body.
Mekinist is used only if you have a mutation in a certain gene for which your doctor will test.
Using Mekinist with dabrafenib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
It is not known if Mekinist is safe and effective in children.
Before taking this medicine
You should not use Mekinist if you are allergic to trametinib.
To make sure Mekinist is safe for you, tell your doctor if you have ever had:
high blood pressure;
liver or kidney disease;
bleeding problems, or a blood clot;
eye problems (especially a problem with your retina); or
if you have ever been treated with dabrafenib or vemurafenib to treat your melanoma.
Using Mekinist with dabrafenib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.
Do not use Mekinist if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose.
Mekinist can make birth control pills, patches, or injections less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking this medicine.
Trametinib may affect fertility (your ability to have children), whether you are a man or a woman.
It is not known whether trametinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using trametinib, and for at least 4 months after your last dose.
How should I take Mekinist?
Take Mekinist exactly as prescribed by your doctor. Your doctor will perform blood tests to make sure you have the correct tumor type to be treated with trametinib.
Mekinist is usually taken once daily. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take on an empty stomach, at least 1 hour before or 2 hours after a meal.
Take the medicine at the same time each day.
Your doctor will need to check your skin on a regular basis while you are using Mekinist.
Your blood pressure will need to be checked often. Your heart function may need to be checked with an electrocardiograph or ECG (sometimes called an EKG) every 2 or 3 months during your treatment. You may also need regular vision examinations while taking Mekinist.
Store in the refrigerator and protect from light. Do not freeze. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. Do not store Mekinist tablets in a pill box.
Mekinist dosing information
Usual Adult Dose for Melanoma - Metastatic:
Single agent: 2 mg orally once a day.
Combination therapy: 2 mg orally once daily with dabrafenib 150 mg orally twice a day.
Duration of therapy: Until disease progression or unacceptable toxicity occurs.
-Take at least 1 hour before or 2 hours after a meal.
-Confirm the presence of BRAF V600E or V600K mutation in tumor specimens prior to initiation.
-Trametinib is not indicated for treatment of patients who have received prior BRAF-inhibitor therapy.
-Continue treatment until disease progression or unacceptable toxicity occurs.
-As a single agent and in combination with dabrafenib for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test.
-Trametinib as a single agent is not indicated for treatment of patients who have received prior BRAF-inhibitor therapy.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Mekinist?
This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Mekinist side effects
Get emergency medical help if you have signs of an allergic reaction to Mekinist: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects are more likely to occur if you take Mekinist and dabrafenib together. Call your doctor at once if you have:
dry cough, wheezing, feeling short of breath;
eye pain or swelling, vision changes, seeing halos around lights, seeing color "dots" in your vision;
severe skin rash, skin pain or swelling, redness and peeling skin on your hands or feet;
fever, chills, feeling light-headed;
high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor;
inflammation or bleeding in your stomach or intestines - fever, nausea, stomach pain, diarrhea;
dangerously high blood pressure - severe headache, blurred vision, pounding in your neck or ears, dizziness;
signs of bleeding - weakness, dizziness, headache, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
signs of a blood clot - chest pain, sudden cough or trouble breathing, pain or swelling in an arm or leg, pale skin or cold feeling in an arm or leg; or
signs of a heart problem - shortness of breath (even with mild exertion), pounding heartbeats, swelling in your feet or ankles.
Common Mekinist side effects may include:
nausea, vomiting, diarrhea, loss of appetite;
fever, chills, tiredness;
cough, shortness of breath;
rash, dry skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Mekinist?
Other drugs may interact with trametinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Mekinist only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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More about Mekinist (trametinib)
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- Drug class: multikinase inhibitors