Generic Name: trametinib (tra ME ti nib)
Brand Names: Mekinist
Medically reviewed by Drugs.com. Last updated on Jul 3, 2018.
What is Mekinist?
Mekinist (trametinib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Mekinist is used alone or in combination with another medicine called dabrafenib (Tafinlar) to treat certain types of cancer in people who have a "BRAF" gene mutation.
Mekinist is for use in treating:
melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body, or to prevent melanoma from coming back after surgery;
non-small cell lung cancer that has spread to other parts of the body; or
advanced or metastatic thyroid cancer that has spread and for which there are no other treatment options.
Using Mekinist with dabrafenib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use Mekinist if you are allergic to trametinib.
Tell your doctor if you have ever had:
heart disease, high blood pressure;
diabetes (dabrafenib may raise your blood sugar);
liver or kidney disease;
a stomach or intestinal disorder;
eye problems (especially a problem with your retina); or
bleeding problems, or a blood clot.
Using Mekinist with dabrafenib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.
Do not use trametinib if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose.
Mekinist can make hormonal birth control less effective (birth control pills, injections, implants, skin patches, vaginal rings). Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important for women to use birth control to prevent pregnancy because trametinib can harm an unborn baby.
You should not breast-feed while using this medicine, and for at least 4 months after your last dose.
How should I take Mekinist?
Take Mekinist exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Your doctor will perform blood tests to make sure you have the correct tumor type to be treated with Mekinist.
Take Mekinist on an empty stomach at the same time each day, at least 1 hour before or 2 hours after a meal.
Your doctor will need to check your skin every 2 months while you are using Mekinist, and for up to 6 months after your last dose.
Your blood pressure will need to be checked often. Your heart function may need to be checked with an electrocardiograph or ECG (sometimes called an EKG) every 2 or 3 months during your treatment. You may also need regular vision examinations.
Store in the refrigerator and protect from light. Do not freeze. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative. Do not store Mekinist tablets in a pill box.
Mekinist dosing information
Usual Adult Dose for Melanoma - Metastatic:
Single agent: 2 mg orally once a day.
Combination therapy: 2 mg orally once daily with dabrafenib 150 mg orally twice a day.
Duration of therapy: Until disease progression or unacceptable toxicity occurs.
-Take at least 1 hour before or 2 hours after a meal.
-Confirm the presence of BRAF V600E or V600K mutation in tumor specimens prior to initiation.
-trametinib is not indicated for treatment of patients who have received prior BRAF-inhibitor therapy.
-Continue treatment until disease progression or unacceptable toxicity occurs.
-As a single agent and in combination with dabrafenib for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations as detected by an FDA-approved test.
-trametinib as a single agent is not indicated for treatment of patients who have received prior BRAF-inhibitor therapy.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Mekinist?
This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Mekinist side effects
Get emergency medical help if you have signs of an allergic reaction to Mekinist: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects are more likely to occur if you take Mekinist and dabrafenib together. Call your doctor at once if you have:
cough, feeling short of breath;
fever, chills, feeling light-headed;
nausea, stomach pain, severe diarrhea;
increased thirst or urination;
eye pain or swelling, vision changes, seeing halos around lights, seeing color "dots" in your vision;
severe skin rash, skin pain or swelling, redness and peeling skin on your hands or feet;
signs of a blood clot - chest pain, sudden cough or trouble breathing, pain or swelling in an arm or leg, pale skin, cold feeling in an arm or leg; or
signs of a heart problem - shortness of breath (even with mild exertion), pounding heartbeats, swelling in your feet or ankles.
Common Mekinist side effects may include:
nausea, vomiting, diarrhea, loss of appetite;
fever, chills, tiredness;
increased blood pressure;
cough, shortness of breath;
rash, dry skin.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Mekinist?
Other drugs may inteact with trametinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Mekinist only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: multikinase inhibitors