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Generic Name: cabozantinib (KA boe ZAN ti nib)
Brand Name: Cabometyx, Cometriq

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 11, 2020.

What is Cometriq?

Cometriq (cabozantinib) interferes with the growth of some cancer cells.

Cometriq is used to treat thyroid cancer that has spread to other parts of the body.

The Cabometyx brand of cabozantinib is used to treat advanced kidney cancer and liver cancer in people who have been previously treated with sorafenib (Nexavar).

Important Information

Cometriq may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. Cabozantinib can also increase your risk of serious bleeding.

Call your doctor if you have: severe stomach pain, choking or gagging when you eat or drink, unusual bleeding, bloody or tarry stools, heavy menstrual bleeding, or if you cough up blood.

Before taking this medicine

To make sure Cometriq is safe for you, tell your doctor if you have ever had:

  • an open wound on your skin (or a wound that is still healing);

  • bleeding problems (such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds);

  • high blood pressure;

  • liver disease; or

  • a pre-existing dental problem.

You may need to have a negative pregnancy test before starting this treatment.

Cabozantinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose. Tell your doctor if you think you might be pregnant.

Cometriq may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because cabozantinib can harm an unborn baby.

You should not breastfeed while using this medicine, and for at least 4 months after your last dose.

How should I take Cometriq?

Take Cometriq exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Do not use cabozantinib tablets in place of Cometriq capsules. Take only the pill form your doctor has prescribed. Avoid medication errors by always checking the medicine you receive at the pharmacy.

Take Cometriq on an empty stomach, at least 1 hour before or 2 hours after you eat anything.

Do not take this medicine with food.

Take Cometriq with a full glass of water.

Do not crush, chew, or break a tablet, and do not open a capsule. Swallow the pill whole.

Your blood pressure will need to be checked often.

If you need surgery or dental work, stop taking Cometriq at least 3 weeks ahead of time. After a surgery or dental procedure, you may need to wait 2 weeks before you start taking Cometriq again. Follow your doctor's dosing instructions very carefully.

If you have stopped taking Cometriq for any reason, talk with your doctor before you start taking it again.

Store at room temperature away from moisture and heat.

Cometriq dosing information

Usual Adult Dose for Thyroid Cancer:

140 mg orally once a day.

Duration of therapy: Until disease progression or unacceptable toxicity occurs.

-Instruct patients not to eat for at least 2 hours before and at least 1 hour after taking this drug.
-Advise patients the capsule form of this drug cannot be substituted with the tablet form of this drug.

Use: Treatment of progressive, metastatic medullary thyroid cancer (MTC).

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Cometriq?

Grapefruit may interact with cabozantinib and lead to unwanted side effects. Avoid the use of grapefruit products while taking Cometriq.

Cometriq side effects

Get emergency medical help if you have signs of an allergic reaction to Cometriq: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cometriq may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.

Call your doctor at once if you have:

  • vomiting, diarrhea, or constipation that are severe and ongoing;

  • bloody or tarry stools, cough with bloody mucus or vomit that looks like coffee grounds;

  • heavy menstrual bleeding, or any other bleeding that will not stop;

  • pain, blisters, bleeding, or severe rash in the palms of your hands or the soles of your feet;

  • swelling in your hands, arms, legs, or feet;

  • confusion, headache, vision changes, thinking problems;

  • a seizure;

  • a light-headed feeling, like you might pass out;

  • jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work;

  • heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, sweating; or

  • signs of a stroke or blood clot - numbness or weakness on one side of your body, sudden severe headache, problems with vision or balance, trouble speaking or understanding what is said to you, trouble breathing, swelling or pain in your arms or legs.

Your future doses of Cometriq may be delayed or permanently discontinued if you have certain side effects.

Common Cometriq side effects include:

  • nausea, vomiting, loss of appetite;

  • diarrhea, constipation;

  • painful rash on your hands or feet;

  • high blood pressure;

  • feeling tired;

  • weight loss; or

  • abnormal liver function tests or other blood tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cometriq?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may interact with cabozantinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cometriq only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Popular FAQ

Cabometyx (cabozantinib) is taken until disease progression - the cancer starts to get worse - or you can no longer tolerate therapy because of the side effects or adverse reactions.

In clinical trials the median amount of time patients took Cabometyx for before their cancer progressed was:

  • METEOR trial - 7.4 months (95% CI 5.6, 9.1)
  • CABOSUN trial - 8.6 months (95% CI 6.8, 14.0)
  • CELESTIAL trial - 5.2 months (95% CI 4.0, 5.5)

Cabometyx (cabozantinib) is a tyrosine kinase inhibitor, which works by helping to stop the out-of-control growth that cancer cells display.

Carbometyx works by blocking the signals between cells that promote the growth of new blood vessels and encourage cells to divide and grow. In doing so, it decreases the ability of tumors to spread (metastasize) to other parts of the body and invade surrounding areas. Continue reading

Cabometyx is a small molecule chemotherapy drug used to treat patients with advanced renal cell carcinoma (kidney cancer) and patients with hepatocellular carcinoma (liver cancer) who have previously been treated with Nexavar (sorafenib).

Cabometyx comes in tablet form and is available in three different strength yellow tablets including a:

  • 60 mg oval tablet
  • 40 mg triangular tablet
  • 20 mg round tablet

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