What is the difference between Cabometyx and Cometriq?

Medically reviewed by N. France, BPharm. Last updated on Sep 24, 2021.

Official Answer

by Drugs.com

Cabometyx and Cometriq are two brand name drugs that both contain the same active ingredient cabozantinib, a kinase inhibitor used to treat certain types of cancer. Cabozantinib inhibits multiple tyrosine kinases, including the MET, AXL and VEGF receptors.

Cabometyx and Cometriq are taken once per day and are both marketed by Exelixis in the US.

The two drugs are not bioequivalent however. That is to say, you can’t switch between the two brands.

Cabometyx and Cometriq come in different oral formulations and are used to treat different types of cancer

	Cabometyx	Cometriq
Marketed since	2016	2012
Dosage form	Tablets	Capsules
Strength	20, 40 and 60 mg	20 and 80 mg
Used to treat	Advanced renal cell carcinoma (RCC) Advanced RCC as a first-line treatment in combination with nivolumab Hepatocellular carcinoma (HCC) in patients who have previously been treated with sorafenib Locally advanced or metastatic differentiated thyroid cancer that has progressed following VEGFR-targeted therapy in people who do not respond to or are unable to take radioactive iodine	Progressive metastatic medullary thyroid cancer (MTC)

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Drug Information

• Cabometyx
• Cabozantinib
• Cometriq

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