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Carafate Side Effects

Generic Name: sucralfate

Note: This document contains side effect information about sucralfate. Some of the dosage forms listed on this page may not apply to the brand name Carafate.

For the Consumer

Applies to sucralfate: oral suspension, oral tablet

Along with its needed effects, sucralfate (the active ingredient contained in Carafate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sucralfate:

Signs of aluminum toxicity
  • Drowsiness
  • convulsions (seizures)

Some side effects of sucralfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Constipation
Less common or rare
  • Backache
  • diarrhea
  • dizziness or lightheadedness
  • dryness of mouth
  • indigestion
  • nausea
  • skin rash, hives, or itching
  • stomach cramps or pain

For Healthcare Professionals

Applies to sucralfate: compounding powder, oral suspension, oral tablet

General

The most commonly reported side effect was constipation.[Ref]

Gastrointestinal

Common (1% to 10%): Constipation
Uncommon (0.1% to 1%): Dry mouth, nausea
Rare (0.01% to 0.1%): Bezoar formation
Frequency not reported: Diarrhea, vomiting, gastric discomfort, indigestion, flatulence
Postmarketing reports: Lip swelling, mouth edema[Ref]

Bezoars were reported in patients with enteral feedings, delayed gastric emptying, and/or low birthweight neonates.[Ref]

Nervous system

Encephalopathy occurred in patients with chronic renal impairment and/or on long-term treatment.

Cerebral emboli occurred in patients receiving IV administration.[Ref]

Common (1% to 10%): Headache
Frequency not reported: Dizziness, drowsiness/sleepiness, vertigo, encephalopathy
Postmarketing reports: Cerebral emboli[Ref]

Dermatologic

Uncommon (0.1% to 1%): Urticaria
Rare (0.01% to 0.1%): Rash
Frequency not reported: Pruritus[Ref]

Musculoskeletal

Osteodystrophy and osteomalacia occurred in patients with chronic renal impairment and/or on long-term treatment.[Ref]

Frequency not reported: Back pain, osteodystrophy, osteomalacia[Ref]

Hypersensitivity

Frequency not reported: Anaphylactic reaction, hypersensitivity reactions[Ref]

Respiratory

Pulmonary edema occurred after IV administration.[Ref]

Frequency not reported: Dyspnea
Postmarketing reports: Bronchospasm, laryngeal edema, pharyngeal edema, respiratory tract edema, pulmonary emboli[Ref]

Other

Frequency not reported: Thirst
Postmarketing reports: Face edema[Ref]

Hematologic

Anemia occurred in patients with chronic renal impairment and/or on long-term treatment.[Ref]

Frequency not reported: Anemia[Ref]

Psychiatric

Frequency not reported: Insomnia[Ref]

Metabolic

Frequency not reported: Hyperglycemia[Ref]

Cardiovascular

Frequency not reported: Edema[Ref]

References

1. "Product Information. Carafate (sucralfate)." Hoechst Marion-Roussel Inc, Kansas City, MO.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Carafate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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