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Carafate Side Effects

Generic Name: sucralfate

Note: This page contains information about the side effects of sucralfate. Some of the dosage forms included on this document may not apply to the brand name Carafate.

For the Consumer

Applies to sucralfate: oral suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by sucralfate (the active ingredient contained in Carafate). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking sucralfate:

Signs of aluminum toxicity
  • Drowsiness
  • convulsions (seizures)

Minor Side Effects

Some of the side effects that can occur with sucralfate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Constipation
Less common or rare:
  • Backache
  • diarrhea
  • dizziness or lightheadedness
  • dryness of mouth
  • indigestion
  • nausea
  • skin rash, hives, or itching
  • stomach cramps or pain

For Healthcare Professionals

Applies to sucralfate: compounding powder, oral suspension, oral tablet


The most commonly reported side effect was constipation.[Ref]


Common (1% to 10%): Constipation
Uncommon (0.1% to 1%): Dry mouth, nausea
Rare (0.01% to 0.1%): Bezoar formation
Frequency not reported: Diarrhea, vomiting, gastric discomfort, indigestion, flatulence
Postmarketing reports: Lip swelling, mouth edema[Ref]

Bezoars were reported in patients with enteral feedings, delayed gastric emptying, and/or low birthweight neonates.[Ref]

Nervous system

Encephalopathy occurred in patients with chronic renal impairment and/or on long-term treatment.

Cerebral emboli occurred in patients receiving IV administration.[Ref]

Common (1% to 10%): Headache
Frequency not reported: Dizziness, drowsiness/sleepiness, vertigo, encephalopathy
Postmarketing reports: Cerebral emboli[Ref]


Uncommon (0.1% to 1%): Urticaria
Rare (0.01% to 0.1%): Rash
Frequency not reported: Pruritus[Ref]


Osteodystrophy and osteomalacia occurred in patients with chronic renal impairment and/or on long-term treatment.[Ref]

Frequency not reported: Back pain, osteodystrophy, osteomalacia[Ref]


Frequency not reported: Anaphylactic reaction, hypersensitivity reactions[Ref]


Pulmonary edema occurred after IV administration.[Ref]

Frequency not reported: Dyspnea
Postmarketing reports: Bronchospasm, laryngeal edema, pharyngeal edema, respiratory tract edema, pulmonary emboli[Ref]


Frequency not reported: Thirst
Postmarketing reports: Face edema[Ref]


Anemia occurred in patients with chronic renal impairment and/or on long-term treatment.[Ref]

Frequency not reported: Anemia[Ref]


Frequency not reported: Insomnia[Ref]


Frequency not reported: Hyperglycemia[Ref]


Frequency not reported: Edema[Ref]


1. "Product Information. Carafate (sucralfate)." Hoechst Marion-Roussel Inc, Kansas City, MO.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Carafate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.