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Amlodipine / benazepril Side Effects

For the Consumer

Applies to amlodipine / benazepril: oral capsule

Along with its needed effects, amlodipine/benazepril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / benazepril:

Less common
  • Confusion
  • dizziness, lightheadedness, or fainting
  • fast or irregular heartbeat
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • swelling of the ankles, feet, or lower legs
  • weakness or heaviness of the legs
  • Bleeding gums
  • chills
  • fever
  • nausea or vomiting
  • nosebleeds
  • pale skin
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • stomach pain or bloating with fever, nausea, or vomiting
  • swelling of the face, mouth, hands, or feet
  • trouble with swallowing or breathing (sudden) or hoarseness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin
Incidence not known
  • Chest pain
  • heartburn
  • pain or burning in the throat

Some side effects of amlodipine / benazepril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Cough (dry and continuous)
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally upper chest
  • sleepiness
Incidence not known
  • Belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • body aches or pain
  • cracked, dry, or scaly skin
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement
  • frequent urination
  • inability to have or keep an erection
  • increased volume of pale, dilute urine
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • muscle or bone pain
  • shakiness in the legs, arms, hands, or feet
  • stomach discomfort or upset
  • sudden sweating
  • swelling
  • tender, swollen glands in the neck
  • trembling or shaking of the hands or feet
  • trouble with sleeping
  • voice changes

For Healthcare Professionals

Applies to amlodipine / benazepril: oral capsule


The most common side effects were cough, headache, dizziness, and edema.[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Frequency not reported: Tremor

Common (1% to 10%): Headache, dizziness
Postmarketing reports: Dysgeusia, hypoesthesia, paresthesia, syncope, peripheral neuropathy, hypertonia

Common (1% to 10%): Headache, dizziness
Postmarketing reports: Paresthesia, dysgeusia[Ref]


Common (1% to 10%): Cough
Frequency not reported: Pharyngitis

Uncommon (0.1% to 1%): Cough
Postmarketing reports: Rhinitis

Common (1% to 10%): Cough[Ref]


Common (1% to 10%): Edema
Frequency not reported: Asthenia, fatigue

Common (1% to 10%): Edema
Postmarketing reports: Malaise

Uncommon (0.1% to 1%): Edema[Ref]

Amlodipine-induced peripheral edema is dose dependent. Benazepril reduces the incidence of edema when added to amlodipine.[Ref]


Frequency not reported: Impotence, polyuria

Postmarketing reports: Micturition disorder, nocturia, erectile dysfunction[Ref]


Frequency not reported: Dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspepsia, esophagitis

Postmarketing reports: Gingival hyperplasia, gastritis[Ref]


Frequency not reported: Back pain, musculoskeletal pain, cramps, muscle cramps

Postmarketing reports: Muscle spasms, arthralgia

Postmarketing reports: Arthralgia, arthritis, myalgia[Ref]


Frequency not reported: Rash, skin nodule, dermatitis

Postmarketing reports: Hyperhidrosis, pruritus, skin discoloration, urticaria, erythema multiform

Postmarketing reports: Stevens-Johnson syndrome, pemphigus, pruritus, photosensitivity reaction[Ref]


Frequency not reported: Insomnia, nervousness, anxiety, libido decreased[Ref]


Frequency not reported: Flushing, hot flashes

Postmarketing reports: Tachycardia, hypotension, vasculitis

Postmarketing reports: Orthostatic symptoms, hypotension, angina pectoris, arrhythmia[Ref]


Postmarketing reports: Visual impairment, diplopia

Postmarketing reports: Impaired vision[Ref]


Frequency not reported: Hypokalemia

Postmarketing reports: Hyperglycemia, weight decrease or gain[Ref]


Postmarketing reports: Allergic reaction[Ref]


Postmarketing reports: Serum creatinine increased, BUN increased, renal impairment[Ref]


Frequency not reported: Neutropenia

Postmarketing reports: Leucocytopenia

Postmarketing reports: Hemolytic anemia, thrombocytopenia, agranulocytosis, neutropenia[Ref]


Postmarketing reports: Jaundice, hepatic enzyme elevations

Postmarketing reports: Pancreatitis[Ref]


1. "Product Information. Lotrel (amlodipine-benazepril)." Ciba Pharmaceuticals, Summit, NJ.

Some side effects of amlodipine / benazepril may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.