Amlodipine / Benazepril Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 12, 2023.

Applies to amlodipine / benazepril: oral capsule.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

You should not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan (Entresto®) within 36 hours of each other.

This medicine may cause serious allergic reactions, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

This medicine may cause angina (chest pain) or a heart attack in certain patients with severe heart or blood vessel disease. Check with your doctor right away if you are having chest pain or discomfort, fast or irregular heartbeat, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, trouble breathing, or sweating.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position or if you have been taking a diuretic (water pill). If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, call your doctor right away.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

Check with your doctor right away if you become sick while taking this medicine, especially with severe nausea, vomiting, or diarrhea that does not stop. These conditions may cause you to lose too much water and lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Before having any type of surgery (including dental surgery) or emergency treatment, tell the doctor or dentist in charge that you are taking this medicine.

This medicine may be less effective in black patients. Black patients also have an increased risk of swelling of the hands, arms, face, mouth, or throat. Talk with your doctor if you have concerns about this.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Serious side effects

Along with its needed effects, amlodipine / benazepril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / benazepril:

Other side effects

Some side effects of amlodipine / benazepril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to amlodipine / benazepril: oral capsule.

General adverse events

The most common side effects were cough, headache, dizziness, and edema.^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness
• Frequency not reported: Tremor

Amlodipine:

• Common (1% to 10%): Headache, dizziness
• Postmarketing reports: Dysgeusia, hypoesthesia, paresthesia, syncope, peripheral neuropathy, hypertonia

Benazepril:

• Common (1% to 10%): Headache, dizziness
• Postmarketing reports: Paresthesia, dysgeusia^[Ref]

Respiratory

• Common (1% to 10%): Cough
• Frequency not reported: Pharyngitis

Amlodipine:

• Uncommon (0.1% to 1%): Cough
• Postmarketing reports: Rhinitis

Benazepril:

• Common (1% to 10%): Cough^[Ref]

Other

• Common (1% to 10%): Edema
• Frequency not reported: Asthenia, fatigue

Amlodipine:

• Common (1% to 10%): Edema
• Postmarketing reports: Malaise

Benazepril:

• Uncommon (0.1% to 1%): Edema^[Ref]

Amlodipine-induced peripheral edema is dose dependent. Benazepril reduces the incidence of edema when added to amlodipine.^[Ref]

Genitourinary

• Frequency not reported: Impotence, polyuria

Amlodipine:

• Postmarketing reports: Micturition disorder, nocturia, erectile dysfunction^[Ref]

Gastrointestinal

• Frequency not reported: Dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspepsia, esophagitis

Amlodipine:

• Postmarketing reports: Gingival hyperplasia, gastritis^[Ref]

Musculoskeletal

• Frequency not reported: Back pain, musculoskeletal pain, cramps, muscle cramps

Amlodipine:

• Postmarketing reports: Muscle spasms, arthralgia

Benazepril:

• Postmarketing reports: Arthralgia, arthritis, myalgia^[Ref]

Dermatologic

• Frequency not reported: Rash, skin nodule, dermatitis

Amlodipine:

• Postmarketing reports: Hyperhidrosis, pruritus, skin discoloration, urticaria, erythema multiform

Benazepril:

• Postmarketing reports: Stevens-Johnson syndrome, pemphigus, pruritus, photosensitivity reaction^[Ref]

Psychiatric

• Frequency not reported: Insomnia, nervousness, anxiety, libido decreased^[Ref]

Cardiovascular

• Frequency not reported: Flushing, hot flashes

Amlodipine:

• Postmarketing reports: Tachycardia, hypotension, vasculitis

Benazepril:

• Postmarketing reports: Orthostatic symptoms, hypotension, angina pectoris, arrhythmia^[Ref]

Ocular

Amlodipine:

• Postmarketing reports: Visual impairment, diplopia

Benazepril:

• Postmarketing reports: Impaired vision^[Ref]

Metabolic

• Frequency not reported: Hypokalemia

Amlodipine:

• Postmarketing reports: Hyperglycemia, weight decrease or gain^[Ref]

Immunologic

Amlodipine:

• Postmarketing reports: Allergic reaction^[Ref]

Renal

• Postmarketing reports: Serum creatinine increased, BUN increased, renal impairment^[Ref]

Benazepril

Hematologic

• Frequency not reported: Neutropenia

Amlodipine:

• Postmarketing reports: Leucocytopenia

Benazepril:

• Postmarketing reports: Hemolytic anemia, thrombocytopenia, agranulocytosis, neutropenia^[Ref]

Hepatic

Amlodipine:

• Postmarketing reports: Jaundice, hepatic enzyme elevations

Benazepril:

• Postmarketing reports: Pancreatitis^[Ref]

See also:

Further information

Amlodipine/benazepril side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer