Generic Name: amlodipine and benazepril (am LOE di peen and ben AY ze pril)
Brand Name: Lotrel
What is amlodipine and benazepril?
Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.
Benazepril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Benazepril also widens blood vessels and also prevents the body from retaining water.
Amlodipine and benazepril is a combination medicine used to treat high blood pressure (hypertension).
Amlodipine and benazepril may also be used for purposes not listed in this medication guide.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.
You should not use this medicine if you have ever had angioedema. Do not take this medicine within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
Before taking this medicine
You should not use this medicine if you are allergic to amlodipine or benazepril, or if:
you have had angioedema (hives or severe swelling of deep skin tissues sometimes caused by allergic reaction);
you recently took a heart medicine called sacubatril; or
Do not take amlodipine and benazepril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
If you have diabetes, do not use amlodipine and benazepril together with any medication that contains aliskiren (Tekturna, Tekamlo).
You may also need to avoid taking amlodipine and benazepril with aliskiren if you have kidney disease.
To make sure amlodipine and benazepril is safe for you, tell your doctor if you have:
heart disease or congestive heart failure;
high levels of potassium in your blood (hyperkalemia);
kidney disease (or if you are on dialysis);
liver disease; or
if you are on a low-salt diet.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Benazepril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
Amlodipine and benazepril can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medicine.
How should I take amlodipine and benazepril?
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
You may take amlodipine and benazepril with or without food. Take the medicine at the same time each day.
Your blood pressure will need to be checked often, and you may also need frequent blood tests.
If you need surgery, tell the surgeon ahead of time that you are using amlodipine and benazepril. You may need to stop using the medicine for a short time.
You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use amlodipine and benazepril.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking amlodipine and benazepril?
Drinking alcohol with this medicine can cause side effects.
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Do not use salt substitutes or potassium supplements while taking amlodipine and benazepril, unless your doctor has told you to.
Amlodipine and benazepril side effects
Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Some side effects may not occur until after you have used the medicine for several months.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
swelling in your hands or feet, rapid weight gain;
new or worsened chest pain;
high potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
liver problems--nausea, stomach pain (upper right side), itching, unusual tiredness, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes).
Common side effects may include:
swelling in your hands or feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Amlodipine and benazepril dosing information
Usual Adult Dose for Hypertension:
Initial dose: Amlodipine 2.5 mg-Benazepril 10 mg orally once a day
Maintenance dose: Amlodipine 2.5 to 10 mg-Benazepril 10 to 40 mg orally once a day
Maximum dose: Amlodipine: 10 mg/day; Benazepril 80 mg/day
-May increase dose after 2 weeks as needed to achieve blood pressure goal.
-Adding benazepril to amlodipine should not be expected to provide additional blood pressure reduction in African Americans.
What other drugs will affect amlodipine and benazepril?
Many drugs can interact with amlodipine and benazepril. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:
a diuretic or "water pill";
gold injections to treat arthritis;
a shot for bee-sting allergy;
heart or blood pressure medication;
insulin or oral diabetes medicine;
This list is not complete and many other drugs can interact with amlodipine and benazepril. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
More about amlodipine/benazepril
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 41 Reviews – Add your own review/rating
- Drug class: ACE inhibitors with calcium channel blocking agents
Other brands: Lotrel
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about amlodipine and benazepril.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 9.05.
Last reviewed: October 02, 2017
Date modified: February 01, 2018