Amlodipine / Benazepril Dosage
Medically reviewed by Drugs.com. Last updated on Apr 7, 2025.
Applies to the following strengths: 10 mg-20 mg; 10 mg-40 mg; 5 mg-40 mg; 2.5 mg-10 mg; 5 mg-10 mg; 5 mg-20 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: Amlodipine 2.5 mg-Benazepril 10 mg orally once a day
Maintenance dose: Amlodipine 2.5 to 10 mg-Benazepril 10 to 40 mg orally once a day
Maximum dose: Amlodipine: 10 mg/day; Benazepril 80 mg/day
Comments:
- May increase dose after 2 weeks as needed to achieve blood pressure goal.
- Adding benazepril to amlodipine should not be expected to provide additional blood pressure reduction in African Americans.
Renal Dose Adjustments
CrCl greater than 30 mL/min: No adjustment recommended
CrCl 30 mL/min or less: Not recommended
Liver Dose Adjustments
Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.
Precautions
US BOXED WARNING:
- FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Monitoring:
- Assess renal function and serum electrolytes prior to initiating therapy and periodically during treatment.
- Monitor congestive heart failure patients closely for the first 2 weeks of treatment with this drug and following a dose increase of this drug or a concomitant diuretic.
Patient advice:
- Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.
- Advise patients to immediately report any signs or symptoms of angioedema (breathing difficulty or swelling of face, eyes, lips, or tongue) and to stop taking this drug until consulting a physician.
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