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Lupron Depot

Generic Name: leuprolide (LOO proe lide)
Brand Name: Eligard, Lupron Depot

Medically reviewed on March 5, 2018

What is Lupron Depot?

Lupron Depot overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. This medicine reduces the amount of testosterone in men or estrogen in women.

Lupron Depot is used in men to treat the symptoms of prostate cancer (but does not treat the cancer itself). This medicine is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.

Lupron Depot is also used to treat precocious (early-onset) puberty in both male and female children.

Lupron Depot may also be used for purposes not listed in this medication guide.

Important Information

Certain brands or strengths of Lupron Depot are only for men and should not be used by women or children.

Your symptoms may become temporarily worse when you first start using Lupron Depot. Tell your doctor if this continues for longer than 2 months.

Call your doctor at once if you have a seizure, or unusual changes in mood or behavior.

Do not use if you are pregnant.

Before taking this medicine

You should not use this medicine if you are allergic to Lupron Depot or similar medicines such as buserelin, goserelin, histrelin, nafarelin, or if you have abnormal vaginal bleeding that has not been checked by a doctor.

Certain brands or strengths of Lupron Depot are used to treat only men and should not be used in women or children. Always check your medicine to make sure you have received the correct brand and strength.

Lupron Depot can cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant.

Tell your doctor if you have ever had:

Do not give this medicine to any child without medical advice.

Lupron Depot usually causes women to stop ovulating or having menstrual periods. However, you may still be able to get pregnant. Use a condom or diaphragm with spermicide to prevent pregnancy. This medicine can make hormonal birth control less effective (birth control pills, injections, implants, skin patches, vaginal rings).

Call your doctor if your periods continue while you are being treated with this medicine.

You should not breast-feed while using this medicine.

How should I use Lupron Depot?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Different brands or strengths of Lupron Depot are used to treat different conditions. It is very important that you receive exactly the brand and strength your doctor has prescribed. Always check your medication to make sure you have received the correct brand and type prescribed by your doctor.

Lupron Depot is injected under the skin or into a muscle, once every month or once every 3 to 6 months. A healthcare provider can teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use Lupron Depot if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Your symptoms may become temporarily worse as your hormones adjust to Lupron Depot. Keep using the medicine as directed, and tell your doctor if your condition is still worse after 2 months of using this medicine.

Lupron Depot can have long lasting effects on your body. You may need frequent medical tests while using this medicine and for a short time after your last dose.

Store Lupron in the original carton at room temperature, away from moisture and heat. Protect from light.

Store Eligard in the refrigerator. Do not freeze. You may take the medicine out and allow it to reach room temperature before mixing and injecting your dose. Mixed medicine must be used within 30 minutes.

You may also store Eligard in its original packaging at room temperature for up to 8 weeks.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Lupron Depot?

This medicine can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Lupron Depot side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • bone pain, loss of movement in any part of your body;

  • swelling, rapid weight gain;

  • a seizure;

  • unusual changes in mood or behavior (crying spells, anger, feeling irritable);

  • sudden chest pain or discomfort, wheezing, dry cough or hack;

  • painful or difficult urination; or

  • high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor.

Rare but serious side effects may occur. Call your doctor if you have:

  • pain or unusual sensations in your back, numbness, weakness, or tingly feeling in your legs or feet;

  • muscle weakness or loss of use, loss of bowel or bladder control;

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech.

Common side effects may include:

  • hot flashes, sweating, acne, rash, itching, scaly skin;

  • mood changes;

  • headache, general pain;

  • vaginal swelling, itching, or discharge;

  • breakthrough bleeding;

  • weight gain;

  • decreased testicle size; or

  • redness, pain, swelling, or oozing where the shot was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Lupron Depot?

Lupron Depot can cause a serious heart problem, especially if you use certain medicines at the same time, such as antibiotics, antifungal medicine, antidepressants, anti-malaria medicine, asthma inhalers, antipsychotic medicine, cancer medicine, certain HIV/AIDS medicine, heart or blood pressure medicine, or medicine to prevent vomiting. Tell your doctor about all your current medicines and any medicine you start or stop using.

Other drugs may interact with leuprolide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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