Skip to main content

Ibuprofen injection

Generic name: ibuprofen injection [ EYE-bue-proe-fen ]
Brand names: Caldolor, NeoProfen
Dosage forms: intravenous solution ((as lysine) 10 mg/mL, 100 mg/mL, 800 mg/200 mL)
Drug class: Nonsteroidal anti-inflammatory drugs

Medically reviewed by on May 5, 2022. Written by Cerner Multum.

What is ibuprofen?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce fever and treat pain.

Neoprofen is used in premature babies to treat a condition called patent ductus arteriosus (an abnormal blood vessel opening that normally closes shortly after birth).

Ibuprofen may also be used for purposes not listed in this medication guide.

Ibuprofen side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop using ibuprofen and seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.

Tell your medical caregivers right away if you have:

If your baby has been treated with Neoprofen, tell the doctor at once if the baby has:

Common side effects of ibuprofen injection may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Ibuprofen can increase your risk of fatal heart attack or stroke. Do not use ibuprofen injection just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal.

Before taking this medicine

Ibuprofen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. This can occur without warning, especially in older adults.

You should not be treated with ibuprofen if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Tell your doctor if you have ever had:

If you are pregnant, you should not take ibuprofen unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

Ask a doctor if it is safe to breastfeed while using this medicine.

How is ibuprofen injection given?

Ibuprofen is injected into a vein by a healthcare provider.

Drink plenty of liquids while you are receiving ibuprofen injection.

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving ibuprofen?

Avoid taking aspirin while you are receiving ibuprofen, unless your doctor tells you to.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to ibuprofen (such as aspirin, ketoprofen, or naproxen).

What other drugs will affect ibuprofen?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect ibuprofen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

There are no known drug interactions between Ajovy (fremanezumab) and ibuprofen (Advil, Motrin), but you should talk to your doctor before you combine these medications. Serious side effects can occur with ibuprofen, such as stomach or intestinal bleeding, rash, swelling, problems with your kidneys, or an increased risk of heart attack and stroke.

Ajovy is used to help prevent migraine episodes in adults. Ibuprofen is an over-the-counter analgesic used as an acute treatment to help stop migraine pain already in progress. If Ajovy is not adequately helping your migraine, your doctor may want to switch you to a different migraine prevention medicine or drug class.

Ibuprofen is short acting, while naproxen is long acting and more likely to cause an upset stomach. Naproxen and ibuprofen are both NSAIDs so they are similar in many ways, but there are important differences. Continue reading

Even though aspirin and Ibuprofen are both NSAIDs (nonsteroidal anti-inflammatory drugs) and work similarly, there are several differences between the two drugs and they are not considered interchangeable. Continue reading

Despite popular belief that you have to take ibuprofen with food, you can take ibuprofen on an empty stomach and this will give you faster pain relief than taking it with food. Food increases the time it takes for ibuprofen to be absorbed, although it won't affect how much is absorbed. There is actually no evidence that taking ibuprofen with food prevents gastric irritation – ibuprofen at OTC doses has a low incidence of gastric irritation anyway. Continue reading

Although taking expired ibuprofen is not recommended by the manufacturer, the actual shelf-life is likely to be longer than that indicated by the expiry date, with FDA testing showing many drugs are active for years beyond their expiry date, although specific data on ibuprofen is not available. Within reason, an ibuprofen tablet that is a few months past its expiry date is probably safe to take. Ibuprofen that is years past its expiry date should not be taken. Continue reading

Despite ibuprofen having a wide safety margin, it is possible to overdose on it, but death from ibuprofen overdose is rare. Children are more susceptible to the effects of ibuprofen and likely to experience an overdosage of ibuprofen if dosages of more than 400mg/kg (in the range of 8000mg for a 20kg child [the equivalent of 40 x 200mg ibuprofen tablets]) are ingested. Studies have reported patients ingesting less than 99 mg/kg are unlikely to have symptoms. Continue reading

More FAQ

View more FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.