Xiidra vs. Restasis: Which is better for dry eye?
Xiidra (lifitegrast) and Restasis (cyclosporine) are prescription eye drops used to treat dry eye disease, but they work differently and have distinct characteristics.
Xiidra:
- Contains lifitegrast, an LFA-1 antagonist that reduces inflammation and improves tear quality.
- Recommended dosage is one drop in each eye twice daily.
- Can start working in as little as 14 days, but may take up to 12 weeks for some patients.
- Common side effects include eye irritation, discomfort, and an unusual taste.
Restasis:
- Contains cyclosporine, a partial immunomodulator classified as a calcineurin inhibitor.
- Recommended dosage is one drop in each eye twice daily.
- Takes up to 12 weeks for noticeable effects and up to 6 months for full benefits.
- Common side effects include temporary burning, redness, watery eyes, and blurred vision.
Key Differences:
- Xiidra works faster for some, while Restasis may take longer for full effect.
- They target different aspects of inflammation and tear production.
- Both can cause similar side effects, such as burning and stinging.
Usage Note:
- Do not use Xiidra and Restasis together unless directed by a doctor, as this can increase side effects.
Bottom Line:
Xiidra may offer quicker relief for some, but Restasis is also effective over a longer period. Discuss with your doctor to determine which is better suited for you.
References
- Xiidra [package insert]. Novartis Pharmaceuticals. East Hanover, NJ. Updated June 2020. https://www.novartis.us/sites/www.novartis.us/files/xiidra.pdf
- Xiidra.com. https://www.xiidra.com/what-is-xiidra/
- Restasis.com. https://www.restasis.com/about-restasis/how-it-works
- Restasis [package insert]. Irvine, California: Allergan, 2017. https://www.rxabbvie.com/pdf/restasis_pi.pdf
- Pflugfelder SC, de Paiva CS. The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology. 2017;124(11S):S4–S13. doi:10.1016/j.ophtha.2017.07.010
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