Tetracyclines are broad-spectrum antibiotics derived from cultures of Streptomyces bacteria, and work by inhibiting protein synthesis after uptake into susceptible organisms. They work by reversibly binding to the 30S ribosome of the microbial RNA and preventing the attachment of aminoacyl-tRNA with the acceptor site on the 70S ribosome. Their activity is bacteriostatic and not bacteriocidal.
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