Tetracyclines are a class of antibiotics with broad-spectrum activity (activity against a wide range of microorganisms including gram positive and gram negative bacteria, protozoa and chlamydiae). They were discovered in the 1940s and the first tetracyclines were obtained or derived from Streptomyces bacteria. Although still in widespread use, both in human and veterinary medicine, bacterial resistance is of major concern.
Tetracyclines inhibit protein synthesis in the microbial RNA by reversibly binding to the 30S ribosome and preventing the attachment of aminoacyl-tRNA to the ribosomal acceptor site. They are primarily bacteriostatic (prevent bacteria from reproducing but don't necessarily kill them).
Subscribe to receive email notifications whenever new articles are published.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex® (updated Dec 4th, 2017), Cerner Multum™ (updated Dec 5th, 2017), Wolters Kluwer™ (updated Dec 1st, 2017) and others. To view content sources and attributions, please refer to our editorial policy.