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Generic name: eravacycline [ ER-a-va-SYE-kleen ]
Brand name: Xerava
Dosage form: intravenous powder for injection (100 mg; 50 mg)
Drug class: Tetracyclines

Medically reviewed by on Oct 24, 2022. Written by Cerner Multum.

What is eravacycline?

Eravacycline is a tetracycline antibiotic that is used to treat serious stomach infections in adults.

Eravacycline may also be used for purposes not listed in this medication guide.


You should not use eravacycline if you are allergic to any tetracycline antibiotic.

Using eravacycline during pregnancy may affect tooth and bone development in the unborn baby.

Eravacycline is not approved for use by anyone younger than 18 years old. Eravacycline can cause permanent yellowing or graying of the teeth in children.

Before taking this medicine

You should not use this medicine if you are allergic to eravacycline or other tetracycline antibiotics such as demeclocycline, doxycycline, minocycline, tetracycline, or tigecycline.

Tell your doctor if you have ever had:

Using eravacycline during the second or third trimester of pregnancy may affect tooth and bone development in the unborn baby. This could cause permanent tooth discoloration later in the baby's life.

Eravacycline can pass into breast milk and may affect bone and tooth development in a nursing infant. Do not breastfeed while you are using eravacycline, and for at least 4 days after your last dose.

Eravacycline is not approved for use by anyone younger than 18 years old. Eravacycline can cause permanent yellowing or graying of the teeth in children.

How should I use eravacycline?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Eravacycline is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Do not use eravacycline if you don't understand all instructions for proper use. Ask your doctor or pharmacist if you have questions.

Eravacycline must be given slowly, and the infusion can take at least 1 hour to complete.

Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Use eravacycline for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Eravacycline will not treat a viral infection such as the flu or a common cold.

Store unmixed eravacycline powder in the refrigerator, do not freeze.

Mixed eravacycline must be used within 6 hours if you keep it at room temperature, or 24 hours if kept in a refrigerator. Do not freeze.

Each single-use vial (bottle) of this medicine is for one use only. Throw it away after one use, even if there is still medicine left inside.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using eravacycline?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Eravacycline could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Eravacycline side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Eravacycline may cause serious side effects. Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (may occur up to 2 months after your last dose of eravacycline);

  • severe headaches, dizziness, ringing in your ears, vision problems;

  • severe pain in your upper stomach spreading to your back, nausea and vomiting; or

  • signs of a fungal infection--skin itching or crusting, white patches in your mouth, vaginal itching or discharge, problems with your fingernails or toenails.

Common side effects of eravacycline may include:

  • nausea, vomiting; or

  • pain, bruising, redness, swelling, burning, or irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Eravacycline dosing information

Usual Adult Dose for Intraabdominal Infection:

1 mg/kg IV every 12 hours for 4 to 14 days

Use: For the treatment of complicated intraabdominal infections due to susceptible Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, K oxytoca, Enterococcus faecalis, E faecium, Staphylococcus aureus, Streptococcus anginosus group, Clostridium perfringens, Bacteroides species, Parabacteroides distasonis

What other drugs will affect eravacycline?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect eravacycline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.