Eravacycline Side Effects
Medically reviewed by Drugs.com. Last updated on Jun 28, 2024.
Applies to eravacycline: intravenous powder for solution.
Precautions
It is very important that your doctor check your progress closely while you are receiving this medicine to make sure it is working properly. Blood tests may be needed to check for unwanted effects.
Tell your doctor if you are pregnant or planning to get pregnant. You should not receive this medicine during the second or third part of a pregnancy.
This medicine may cause permanent discoloration of the teeth and slow down the growth of bones in children younger than 8 years of age. Talk with your doctor if you have concerns.
Eravacycline may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop receiving this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.
Avoid overexposing your skin to sunlight. Always use sunscreen or sun blocking lotions and wear protective clothing and hats while you are receiving this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Common side effects of eravacycline
Some side effects of eravacycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- dry, red, hot, or irritated skin
Rare side effects
- anxiety
- change in taste
- discouragement
- feeling sad or empty
- loss of interest or pleasure
- loss of taste
- trouble concentrating
- trouble sleeping
Serious side effects of eravacycline
Along with its needed effects, eravacycline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking eravacycline:
Less common side effects
- bleeding wound
- blurred vision
- confusion
- diarrhea
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- red, tender, or oozing skin at the incision site
- sweating
- unusual tiredness or weakness
Rare side effects
- black, tarry, stools
- bloating
- chest pain
- chills
- constipation
- cough
- dark urine
- difficult or labored breathing
- fast, irregular, pounding, or racing heartbeat or pulse
- fever
- hives, itching, skin rash
- hoarseness
- indigestion
- irritation
- joint pain, stiffness or swelling
- loss of appetite
- lower back or side pain
- mood or mental changes
- muscle cramps in the hands, arms, feet, legs, or face
- nausea
- numbness and tingling around the mouth, fingertips, or feet
- painful or difficult urination
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pale skin
- redness of the skin
- seizures
- sore throat
- stomach cramps
- swelling of the eyelids, face, lips, hands, or feet
- tightness in the chest
- tremor
- troubled breathing or swallowing
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- vomiting
- yellow eyes or skin
For healthcare professionals
Applies to eravacycline: intravenous powder for injection.
General adverse events
The most common side effects were infusion site reactions, nausea, and vomiting. This drug was discontinued due to side effects in 2% of patients (compared to 2% for comparator); discontinuation was most often due to gastrointestinal disorders.[Ref]
Cardiovascular
- Common (1% to 10%): Hypotension, thrombophlebitis (includes thrombophlebitis, infusion site thrombosis), phlebitis (includes phlebitis, infusion site phlebitis, superficial phlebitis, injection site phlebitis)
- Frequency not reported: Palpitations
Dermatologic
- Uncommon (0.1% to 1%): Rash, hyperhidrosis
Tetracycline class:
- Frequency not reported: Photosensitivity
Gastrointestinal
- Common (1% to 10%): Nausea, vomiting, diarrhea
- Uncommon (0.1% to 1%): Pancreatitis
- Frequency not reported: Acute pancreatitis, pancreatic necrosis, increased amylase, increased lipase
Antibiotic class:
- Uncommon (0.1% to 1%): Treatment-related diarrhea
- Frequency not reported: Pseudomembranous colitis
Hematologic
- Frequency not reported: Prolonged activated partial thromboplastin time, decreased WBC count, neutropenia
Hepatic
- Uncommon (0.1% to 1%): Increased ALT, increased AST, hyperbilirubinemia
- Frequency not reported: Increased GGT
Hypersensitivity
- Uncommon (0.1% to 1%): Hypersensitivity
Local
- Common (1% to 10%): Infusion site reactions (includes catheter/vessel puncture site pain, infusion site extravasation, infusion site hypoesthesia, infusion/injection site phlebitis, infusion site thrombosis, injection site/vessel puncture site erythema, phlebitis, superficial phlebitis, thrombophlebitis, vessel puncture site swelling, injection site pain/discomfort, injection site swelling/inflammation), infusion site phlebitis
- Uncommon (0.1% to 1%): Infusion site thrombosis, vessel puncture site erythema, infusion site hypoesthesia
Metabolic
- Frequency not reported: Hypocalcemia
Nervous system
- Uncommon (0.1% to 1%): Dizziness, headache
- Frequency not reported: Dysgeusia
Tetracycline class:
- Frequency not reported: Pseudotumor cerebri
Other
- Common (1% to 10%): Wound dehiscence
- Frequency not reported: Chest pain
Antibiotic class:
- Frequency not reported: Overgrowth of nonsusceptible organisms (including fungi)
Tetracycline class:
- Frequency not reported: Antianabolic action (leading to increased BUN, azotemia, acidosis, hyperphosphatemia)
Psychiatric
- Frequency not reported: Anxiety, insomnia, depression
Renal
- Frequency not reported: Decreased renal clearance of creatinine
Respiratory
- Frequency not reported: Pleural effusion, dyspnea
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References
1. (2022) "Product Information. Xerava (eravacycline)." PAION Deutschland GmbH
2. (2021) "Product Information. Xerava (eravacycline)." Tetraphase Pharmaceuticals, Inc
Frequently asked questions
More about eravacycline
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Further information
Eravacycline side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.