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Eravacycline Side Effects

Medically reviewed by Last updated on Mar 16, 2022.

For the Consumer

Applies to eravacycline: intravenous powder for solution

Side effects requiring immediate medical attention

Along with its needed effects, eravacycline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking eravacycline:

Less common

  • Bleeding wound
  • blurred vision
  • confusion
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • red, tender, or oozing skin at the incision site
  • sweating
  • unusual tiredness or weakness


  • Black, tarry, stools
  • bloating
  • chest pain
  • chills
  • constipation
  • cough
  • dark urine
  • difficult or labored breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • hives, itching, skin rash
  • hoarseness
  • indigestion
  • irritation
  • joint pain, stiffness or swelling
  • loss of appetite
  • lower back or side pain
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • nausea
  • numbness and tingling around the mouth, fingertips, or feet
  • painful or difficult urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • redness of the skin
  • seizures
  • sore throat
  • stomach cramps
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • tremor
  • troubled breathing or swallowing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • vomiting
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of eravacycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dry, red, hot, or irritated skin


  • Anxiety
  • change in taste
  • discouragement
  • feeling sad or empty
  • loss of interest or pleasure
  • loss of taste
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to eravacycline: intravenous powder for injection


The most common side effects were infusion site reactions, nausea, and vomiting. This drug was discontinued due to side effects in 2% of patients (compared to 2% for comparator); discontinuation was most often due to gastrointestinal disorders.[Ref]


Common (1% to 10%): Infusion site reactions (included catheter/vessel puncture site pain, infusion site extravasation, infusion site hypoesthesia, infusion/injection site phlebitis, infusion site thrombosis, injection site/vessel puncture site erythema, phlebitis, superficial phlebitis, thrombophlebitis, vessel puncture site swelling)[Ref]


Common (1% to 10%): Nausea, vomiting, diarrhea

Frequency not reported: Acute pancreatitis, pancreatic necrosis, increased amylase, increased lipase[Ref]


Common (1% to 10%): Hypotension

Frequency not reported: Palpitations[Ref]


Common (1% to 10%): Wound dehiscence

Frequency not reported: Chest pain[Ref]


Frequency not reported: Rash, hyperhidrosis[Ref]


Frequency not reported: Prolonged activated partial thromboplastin time, decreased WBC count, neutropenia[Ref]


Frequency not reported: Increased ALT, increased GGT[Ref]


Frequency not reported: Hypersensitivity[Ref]


Frequency not reported: Hypocalcemia[Ref]

Nervous system

Frequency not reported: Dizziness, dysgeusia[Ref]


Frequency not reported: Anxiety, insomnia, depression[Ref]


Frequency not reported: Decreased renal clearance of creatinine[Ref]


Frequency not reported: Pleural effusion, dyspnea[Ref]

Frequently asked questions


1. "Product Information. Xerava (eravacycline)." Tetraphase Pharmaceuticals, Inc (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.