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Eravacycline Dosage

Medically reviewed by Last updated on Nov 3, 2020.

Applies to the following strengths: 50 mg; 100 mg

Usual Adult Dose for Intraabdominal Infection

1 mg/kg IV every 12 hours for 4 to 14 days

Use: For the treatment of complicated intraabdominal infections due to susceptible Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, K oxytoca, Enterococcus faecalis, E faecium, Staphylococcus aureus, Streptococcus anginosus group, Clostridium perfringens, Bacteroides species, Parabacteroides distasonis

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild to moderate liver dysfunction (Child-Pugh A and B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C):
-First day: 1 mg/kg IV every 12 hours
-Starting on second day: 1 mg/kg IV every 24 hours
Total duration of therapy: 4 to 14 days

Dose Adjustments

Coadministration with a weak or moderate CYP450 3A inducer: No adjustment recommended.
Coadministration with a strong CYP450 3A inducer: 1.5 mg/kg IV every 12 hours
Total duration of therapy: 4 to 14 days


Known hypersensitivity to the active component, tetracycline-class antibacterial agents, or any of the ingredients

Safety and efficacy have not been established in patients younger than 18 years; this drug is not recommended for use in patients younger than 8 years.

Consult WARNINGS section for additional precautions.


Data not available

-Significant removal via hemodialysis is not expected.

Other Comments

Administration advice:
-Administer via IV infusion over about 60 minutes; administer through a dedicated line or through a Y-site.
-If the same IV line is used for sequential infusion of several drugs, flush the line before and after infusion of this drug with 0.9% Sodium Chloride Injection, USP.
-Must infuse reconstituted and diluted solutions within 6 hours if stored at room temperature or 24 hours if stored refrigerated.
-Use severity and location of infection and patient clinical response to guide duration of therapy.

Storage requirements:
-Powder (prior to reconstitution): Store vials at 2C to 8C (36F to 46F); keep vial in carton until use.
-Reconstituted and diluted solutions: May store at room temperature (not to exceed 25C [77F]) or refrigerated at 2C to 8C (36F to 46F); must be infused within 6 or 24 hours, respectively; do not freeze.

Reconstitution/preparation techniques:
-Reconstitute vial(s) with Sterile Water for Injection, USP; swirl gently to dissolve.
-The reconstituted solution must be diluted further in a 0.9% Sodium Chloride Injection, USP infusion bag prior to IV infusion.
-The manufacturer product information should be consulted.

IV compatibility:
-Compatible IV solutions: 0.9% Sodium Chloride Injection, USP
-Compatibility with other drugs and infusion solutions not established.
-This drug should not be mixed with other drugs or added to solutions containing other drugs.

-This drug is not indicated for the treatment of complicated urinary tract infections.
-To reduce the development of drug-resistant organisms and maintain effective therapy, this drug should be used only to treat or prevent infections proven or strongly suspected to be caused by susceptible bacteria.
-Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

Patient advice:
-Avoid missing doses and complete the entire course of therapy.
-Notify healthcare provider immediately if you become pregnant during therapy.
-Contact healthcare provider at once if watery and bloody stools (with or without stomach cramps and fever) develop.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.