Comparing Topiramate vs Amitriptyline
Topiramate | Amitriptyline |
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Topiramate | Amitriptyline |
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Prescription only
Topiramate may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraines. Drowsiness is a... View more |
Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Related suggestions Migraine
Fibromyalgia
Vulvodynia
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More about Topiramate | More about Amitriptyline | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Topiramate has an average rating of 6.3 out of 10 from a total of 1322 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 28% reported a negative effect. |
Amitriptyline has an average rating of 7.6 out of 10 from a total of 1779 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 16% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: topiramate side effects in more detail. |
See also: amitriptyline side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all topiramate prices |
View all amitriptyline prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Eprontia, Qudexy XR, Topamax, Trokendi XR |
N/A |
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Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
56 hours |
16 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 289 drugs are known to interact with topiramate:
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A total of 709 drugs are known to interact with amitriptyline:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
December 24, 1996 |
April 07, 1961 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.