Comparing Rybelsus vs Zepbound
| Rybelsus (semaglutide) | Zepbound (tirzepatide) |
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| Rybelsus (semaglutide) | Zepbound (tirzepatide) |
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Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Prescription only
Prescribed for Weight Loss (Obesity/Overweight), Obstructive Sleep Apnea/Hypopnea Syndrome. Zepbound may also be used for purposes not listed in this medication guide. |
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| More about Rybelsus (semaglutide) | More about Zepbound (tirzepatide) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Rybelsus has an average rating of 6.4 out of 10 from a total of 295 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 23% reported a negative effect. |
Zepbound has an average rating of 8.9 out of 10 from a total of 348 ratings on Drugs.com. 84% of reviewers reported a positive effect, while 1% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Rybelsus side effects |
View all Zepbound side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Rybelsus prices |
View all Zepbound prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other semaglutide brands include: Ozempic, Wegovy | Other tirzepatide brands include: Mounjaro | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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168 hours |
120 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 273 drugs are known to interact with Rybelsus:
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A total of 414 drugs are known to interact with Zepbound:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 20, 2019 |
N/A |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.