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Zepbound Dosage

Generic name: tirzepatide 2.5mg in 0.5mL
Dosage form: subcutaneous injection
Drug class: GLP-1 Agonists (Incretin Mimetics)

Medically reviewed by Drugs.com. Last updated on Dec 20, 2024.

Recommended Dose Escalation Schedule

  • The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks.
  • The 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage.
  • Follow the dosage escalation below for all indications to reduce the risk of gastrointestinal adverse reactions.
  • After 4 weeks, increase the dosage to 5 mg injected subcutaneously once weekly. The dosage may be increased in 2.5 mg increments, after at least 4 weeks on the current dose.
  • Consider treatment response and tolerability when selecting the maintenance dosage. If patients do not tolerate a maintenance dosage, consider a lower maintenance dosage.

Recommended Maintenance and Maximum Dosage

Recommended Maintenance Dosage

Weight Reduction and Long-Term Maintenance

The recommended maintenance dosage is 5 mg, 10 mg, or 15 mg, injected subcutaneously once weekly.

OSA

The recommended maintenance dosage is 10 mg or 15 mg injected subcutaneously once weekly.

Maximum Recommended Dosage

The maximum dosage of ZEPBOUND for all indications is 15 mg injected subcutaneously once weekly.

Recommendations Regarding Missed Dose

  • If a dose is missed, instruct patients to administer ZEPBOUND as soon as possible within 4 days (96 hours) after the missed dose. If more than 4 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.
  • The day of weekly administration can be changed, if necessary, as long as the time between the two doses is at least 3 days (72 hours).

Important Administration Instructions

  • Prior to initiation of ZEPBOUND, train patients and caregivers on proper injection technique. Refer to the accompanying Instructions for Use for complete administration instructions with illustrations.
  • Instruct patients using the single-dose vial to use a syringe appropriate for dose administration (e.g., a 1 mL syringe capable of measuring a 0.5 mL dose).
  • Inspect ZEPBOUND visually before use. It should appear clear and colorless to slightly yellow. Do not use ZEPBOUND if particulate matter or discoloration is seen.
  • Administer ZEPBOUND in combination with a reduced-calorie diet and increased physical activity.
  • Administer ZEPBOUND once weekly at any time of day, with or without meals.
  • Inject ZEPBOUND subcutaneously in the abdomen, thigh, or upper arm.
  • Rotate injection sites with each dose.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.