Zepbound Dosage
Generic name: tirzepatide 2.5mg in 0.5mL
Dosage form: subcutaneous injection
Drug class: GLP-1 Agonists (Incretin Mimetics)
Medically reviewed by Drugs.com. Last updated on Dec 20, 2024.
Recommended Dose Escalation Schedule
- The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks.
- The 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage.
- Follow the dosage escalation below for all indications to reduce the risk of gastrointestinal adverse reactions.
- After 4 weeks, increase the dosage to 5 mg injected subcutaneously once weekly. The dosage may be increased in 2.5 mg increments, after at least 4 weeks on the current dose.
- Consider treatment response and tolerability when selecting the maintenance dosage. If patients do not tolerate a maintenance dosage, consider a lower maintenance dosage.
Recommended Maintenance and Maximum Dosage
Recommendations Regarding Missed Dose
- If a dose is missed, instruct patients to administer ZEPBOUND as soon as possible within 4 days (96 hours) after the missed dose. If more than 4 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.
- The day of weekly administration can be changed, if necessary, as long as the time between the two doses is at least 3 days (72 hours).
Important Administration Instructions
- Prior to initiation of ZEPBOUND, train patients and caregivers on proper injection technique. Refer to the accompanying Instructions for Use for complete administration instructions with illustrations.
- Instruct patients using the single-dose vial to use a syringe appropriate for dose administration (e.g., a 1 mL syringe capable of measuring a 0.5 mL dose).
- Inspect ZEPBOUND visually before use. It should appear clear and colorless to slightly yellow. Do not use ZEPBOUND if particulate matter or discoloration is seen.
- Administer ZEPBOUND in combination with a reduced-calorie diet and increased physical activity.
- Administer ZEPBOUND once weekly at any time of day, with or without meals.
- Inject ZEPBOUND subcutaneously in the abdomen, thigh, or upper arm.
- Rotate injection sites with each dose.
Frequently asked questions
- Ozempic Side Effects to Watch For
- How do Ozempic, Mounjaro, Wegovy, Zepbound compare for weight loss?
- Why am I not losing weight on Mounjaro?
- Zepbound Vs Mounjaro: Complete Comparison Guide for Weight Loss and Diabetes Treatment
- How do Zepbound and Wegovy compare?
- How much is Zepbound with or without insurance?
- Can you get tirzepatide from a compounding pharmacy?
- How long does it take for Zepbound to work?
- Is Zepbound covered by insurance?
More about Zepbound (tirzepatide)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (212)
- Drug images
- Latest FDA alerts (2)
- Side effects
- During pregnancy
- Support group
- FDA approval history
- Drug class: GLP-1 Agonists (Incretin Mimetics)
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.