Ortho-Prefest Alternatives Compared
| Ortho-Prefest (estradiol / norgestimate) | Estrace Vaginal Cream (estradiol) | Estradiol topical |
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| Ortho-Prefest (estradiol / norgestimate) | Estrace Vaginal Cream (estradiol) | Estradiol topical |
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Prescription only
Prescribed for Prevention of Osteoporosis, Atrophic Urethritis, Atrophic Vaginitis, Postmenopausal Symptoms. Ortho-Prefest may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Atrophic Vaginitis, Atrophic Urethritis. Estrace Vaginal Cream may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Atrophic Vaginitis, Atrophic Urethritis, Overactive Bladder, Dyspareunia. Estradiol topical may also be used for purposes not listed in this medication guide. |
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| More about Estrace Vaginal Cream (estradiol) | More about Estradiol topical | |||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Be the first to share your experience with this drug. |
Estrace Vaginal Cream has an average rating of 6.6 out of 10 from a total of 83 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 23% reported a negative effect. |
Estradiol topical has an average rating of 5.1 out of 10 from a total of 491 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 45% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
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View all Ortho-Prefest side effects |
View all Estrace Vaginal Cream side effects |
View all Estradiol topical side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
Lower cost generic approved |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Estrace Vaginal Cream prices |
View all Estradiol topical prices |
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| Dosage Forms | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
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N/A |
Other estradiol brands include: Estring, Imvexxy, Vagifem, Yuvafem | Estrace Vaginal Cream, Estring, Imvexxy, Vagifem, Yuvafem | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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37 hours |
N/A |
N/A |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 447 drugs are known to interact with Ortho-Prefest:
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A total of 258 drugs are known to interact with Estrace Vaginal Cream:
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A total of 258 drugs are known to interact with Estradiol topical:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||
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| First Approval Date | ||||||||||||||||||
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N/A |
January 31, 1984 |
January 31, 1984 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
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N/A |
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| Professional Resources | ||||||||||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.