Comparing Modafinil vs Xyrem
| Modafinil Remove Modafinil from your drug comparison | Xyrem Remove Xyrem from your drug comparison |
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| Modafinil Remove Modafinil from your drug comparison | Xyrem sodium oxybate Remove Xyrem from your drug comparison | ||||||||||||||||
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Prescribed for Shift Work Sleep Disorder, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome. May also be prescribed off label for ADHD, Chronic Fatigue Syndrome, Depression, Fatigue, Idiopathic... View more |
Xyrem is a schedule III controlled substance when prescribed to treat narcolepsy; however, there is a high risk of abuse associated with it and people who misuse it or sell it to other people are... View more |
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Prescription only |
Prescription only |
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Ratings & Reviews |
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Drug Class |
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Side Effects |
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Commonly reported side effects include: headache, and nausea. See the full modafinil side effects document. |
Common side effects include: dizziness, and nausea. See the full Xyrem side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all modafinil prices |
View all Xyrem prices |
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Generic Availability |
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Yes (this medicine) |
No |
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Dosage Form(s) Available |
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Brand Names |
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| Provigil |
N/A |
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Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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15 hours |
1 hour |
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CSA Schedule**View glossary of terms. |
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Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
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Drug Interactions |
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A total of 431 drugs are known to interact with modafinil:
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A total of 334 drugs are known to interact with Xyrem:
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Alcohol/Food/Lifestyle Interactions |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions |
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First Approval Date |
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December 24, 1998 |
July 17, 2002 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.