Comparing Modafinil vs Xyrem
| Modafinil Remove Modafinil from your drug comparison | Xyrem Remove Xyrem from your drug comparison |
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| Modafinil Remove Modafinil from your drug comparison | Xyrem sodium oxybate Remove Xyrem from your drug comparison | ||||||||||||||||
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Prescribed for Narcolepsy, Shift Work Sleep Disorder, Obstructive Sleep Apnea/Hypopnea Syndrome. May also be prescribed off label for Chronic Fatigue Syndrome, ADHD, Depression, Fatigue, Hypersomnia. |
Prescribed for Narcolepsy, Cataplexy. Xyrem may also be used for purposes not listed in this medication guide. |
Choose a suggestion below |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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7.7
For Depression: I use several antidepressants, and I cannot function without them. Modafinil helped with my chronic fatigue, but it's not an antidepressant in my opinion. I can do a lot of things now. I'm so glad I heard about it. I take 200mg a day. |
7.9
For Narcolepsy: Price gouging For Narcolepsy: I had about 3-years without a full night sleep. Once I started Xyrem, my sense of being tired was gone. I was also taking Provigil. Xyrem was used for the Cataplexy issue and the restless leg syndrome. The downside to Xyrem is that it caused Sleep Apnea, of which did not make my wife happy and after 2-months of using the mask and machine, it was not worth being on Xyrem. Also, it had interactions with other medications. |
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Drug Class |
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Side Effects |
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Commonly reported side effects include: headache, and nausea. See the full modafinil side effects document. |
Common side effects include: dizziness, and nausea. See the full Xyrem side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all modafinil prices |
View all Xyrem prices |
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Generic Availability |
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Yes (this medicine) |
No |
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Dosage Form(s) Available |
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Brand Names |
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| Provigil |
N/A |
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Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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15 hours |
1 hour |
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CSA Schedule**View glossary of terms. |
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Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
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FDA Alerts |
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Drug Interactions |
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A total of 375 drugs are known to interact with modafinil:
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A total of 251 drugs are known to interact with Xyrem:
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Alcohol/Food/Lifestyle Interactions |
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No results found - however, this does not necessarily mean no warnings exist. Always consult with your doctor or pharmacist. |
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Disease Interactions |
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First Approval Date |
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December 24, 1998 |
July 17, 2002 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Depression: Modafinil has helped some of my friends continue with their daily activities amid depression, and develop for the better. I have seen no side effects so far.