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Xyrem and Panic Attacks: What Users Say

Panic attacks: mentioned by 5 users (4.6%)

Based on user experiences from 108 Xyrem reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 10.2%
drowsiness 7.4%
anxiety 5.6%
depression 5.6%
headaches 5.6%
vomiting 5.6%
panic attacks 4.6%
insomnia 3.7%
tiredness 3.7%
tremors 3.7%

Reviews for Xyrem

  • MCa...
  • Taken for 1 to 6 months
  • April 22, 2018

For Narcolepsy "I had to ramp up to the highest dose before it put me to sleep - before that, I'd be in a weird state but not asleep. When I did get to a dose that would put me to sleep, I would take it (10 pm), sleep for 2 hours and wake up (12 am). Then I'd have to wait an hour for the 3-hour minimum before I could take the second dose (1 am). Then I'd wake up after 2 hours again (3 am). I would be in a state I describe as somewhere between a panic attack and a hangover. I couldn't read or really do anything - I'd just have to sit there and wait for it to wear off around dawn. It didn't work for me."

1 / 10
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22 Report
  • 80s...
  • Taken for less than 1 month
  • October 20, 2018

For Narcolepsy "This medication might have ended up being effective for me if I could have tolerated it long enough to get to an effective dose, but I quit taking it because of the side effects. My blood pressure increased from 110/65 to prehypertension, up to 138/90. It also caused mild tachycardia (rapid heart rate). My normal resting heart rate is between 64 and 68. On Xyrem, it was in the 80s and 90s the entire time. I also had anxiety in the morning hours, including a couple of panic attacks. I quit taking it when I became severely depressed."

3 / 10
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17 Report
  • Sev...
  • Taken for 6 months to 1 year
  • April 18, 2022

For Narcolepsy "Worst drug ever. Some nights I wouldn't even sleep, I would be high and euphoric while I had to wake up at 5:30 a.m. to work in the hospital. Severe withdrawal as soon as it wears off, leading to panic attacks and not to mention severe depression. Felt like I never woke up refreshed, I was in a mental fog all day until it was time to take it again, and I built tolerance fast. Worst part, the side effects never mentioned were anxiety and depression until I called the hotline over and over. Even my doctor never heard of that happening. My eyes had discharged, my pupils were huge, and I even pointed it out to my doctor. Felt like I was in a daze for a whole year."

2 / 10
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6 Report

Frequently asked questions

  • Bsm...
  • Taken for less than 1 month
  • October 1, 2021

For Narcolepsy "I was so hopeful that this med was going to fix me. The taste I read was awful, but it wasn't too bad. Tasted like ocean water. I take psych drugs that are sedating and muscle relaxers and opioids, which had to be spread out 6 hours before taking Xyrem. That means ALL my sedating drugs have to be taken by 3 pm, which kind of sucks. Took the first 2.25 dose at 9 pm. Took a half hour to kick in. Fell asleep. Up by 11. Dang. I read you can take the second dose 2.5-4 hours after the first. So at 11:30, took the 2nd dose. Half hour wait again. 1 am rolls around, I'm WIDE AWAKE. I understand it takes some people time to titrate up, and with the low doses, it can be frustrating. But then around 3 am, I had 2 panic attacks, full body flushing, heart racing, severe impending doom feeling. The anxiety lingered throughout the next day. I tried it again on night 2, and the SAME things happened like clockwork. My doctor advised me to come off and said I must not tolerate the drug due to the anxiety. *Crying* back to square one."

2 / 10
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2 Report
  • Joj...
  • Taken for less than 1 month
  • March 13, 2019

For Narcolepsy "I had a bad reaction to Xyrem. Nausea, panic attacks, delusional thoughts, feeling like a bad hangover every day, depressed. I ended up in the emergency room, and I stopped taking this medication."

1 / 10
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17 Report

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