Janumet Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Janumet (metformin / sitagliptin)	Rybelsus (semaglutide)	Mounjaro (tirzepatide)	Enter another drug to compare

Janumet (metformin / sitagliptin)

Rybelsus (semaglutide)

Mounjaro (tirzepatide)

Prescription only

Prescribed for Type 2 Diabetes. Janumet may also be used for purposes not listed in this medication guide.

Prescription only

Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more

Prescription only

Prescribed for Weight Loss (Obesity/Overweight), Type 2 Diabetes. Mounjaro may also be used for purposes not listed in this medication guide.

More about Janumet (metformin / sitagliptin)

More about Rybelsus (semaglutide)

More about Mounjaro (tirzepatide)

Ratings & Reviews

Janumet has an average rating of 6.3 out of 10 from a total of 66 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 29% reported a negative effect.

Rybelsus has an average rating of 6.5 out of 10 from a total of 315 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 22% reported a negative effect.

Mounjaro has an average rating of 8.5 out of 10 from a total of 1457 ratings on Drugs.com. 79% of reviewers reported a positive effect, while 6% reported a negative effect.

View all 66 reviews

View all 315 reviews

View all 1457 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Headaches (15.2%)
Nausea (13.6%)
Diarrhea (10.6%)
Dizziness (10.6%)
Upset stomach (9.1%)
Vomiting (6.1%)
Rash (4.5%)

View all Janumet side effects

Nausea (40.0%)
Diarrhea (20.6%)
Constipation (17.1%)
Loss of appetite (9.2%)
Vomiting (8.3%)
Stomach pain (5.4%)
Upset stomach (5.1%)

View all Rybelsus side effects

Nausea (16.3%)
Constipation (11.8%)
Diarrhea (8.2%)
Loss of appetite (4.7%)
Upset stomach (4.5%)
Vomiting (4.5%)
Burping (3.9%)

View all Mounjaro side effects

Drug Class

Antidiabetic combinations

GLP-1 Agonists (Incretin Mimetics)

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	60 tablet
Strength	500 mg-50 mg
Per unit^*	$5.50
Cost^*	$330.24

View all Janumet prices

Quantity	30 tablet
Strength	3 mg
Per unit^*	$32.74
Cost^*	$982.34

View all Rybelsus prices

Quantity	2 mL
Strength	2.5 mg/0.5 mL
Per unit^*	$531.31
Cost^*	$1,062.62

View all Mounjaro prices

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Dosage Forms

Oral tablet

Oral tablet

Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

17.6 hours

168 hours

120 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 408 drugs are known to interact with Janumet:

26 major drug interactions (133 brand and generic names)
370 moderate drug interactions (1859 brand and generic names)
12 minor drug interactions (43 brand and generic names)

A total of 275 drugs are known to interact with Rybelsus:

16 major drug interactions (37 brand and generic names)
258 moderate drug interactions (1457 brand and generic names)
1 minor drug interactions (10 brand and generic names)

A total of 416 drugs are known to interact with Mounjaro:

16 major drug interactions (37 brand and generic names)
399 moderate drug interactions (2282 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Tirzepatide may affect the absorption of other medications that you take by mouth. In some cases... View more
Talk to your doctor before using alcohol together with tirzepatide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

March 30, 2007

September 20, 2019

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Janumet uses

Rybelsus uses

Mounjaro uses

Professional Resources

Prescribing information

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Janumet Alternatives Compared

See also:

Ozempic

Rybelsus

Mounjaro

Trulicity

Lantus

Tresiba

Levemir

Victoza

Basaglar

Novolog

Further information

Janumet Alternatives Compared

See also:

Further information

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