Janumet Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Janumet (metformin / sitagliptin)	Metformin	Ozempic (semaglutide)	Enter another drug to compare

Janumet (metformin / sitagliptin)

Metformin

Ozempic (semaglutide)

Prescription only

Prescribed for Type 2 Diabetes. Janumet may also be used for purposes not listed in this medication guide.

Prescription only

Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more

Prescription only

Ozempic lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the liver. It is... View more

More about Janumet (metformin / sitagliptin)

More about Metformin

More about Ozempic (semaglutide)

Ratings & Reviews

Janumet has an average rating of 6.3 out of 10 from a total of 66 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 29% reported a negative effect.

Metformin has an average rating of 6.8 out of 10 from a total of 660 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 19% reported a negative effect.

Ozempic has an average rating of 6.6 out of 10 from a total of 1582 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 23% reported a negative effect.

View all 66 reviews

View all 660 reviews

View all 1582 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Headaches (15.2%)
Nausea (13.6%)
Diarrhea (10.6%)
Dizziness (10.6%)
Upset stomach (9.1%)
Vomiting (6.1%)
Rash (4.5%)

View all Janumet side effects

Diarrhea (25.6%)
Nausea (15.3%)
Upset stomach (9.8%)
Stomach pain (4.7%)
Gas (4.5%)
Headaches (4.4%)
Cramps (3.6%)

View all Metformin side effects

Nausea (33.4%)
Diarrhea (16.3%)
Constipation (15.7%)
Vomiting (12.3%)
Burping (8.8%)
Upset stomach (7.5%)
Headaches (7.4%)

View all Ozempic side effects

Drug Class

Antidiabetic combinations

Non-sulfonylureas

GLP-1 Agonists (Incretin Mimetics)

Generic Availability

No lower cost generic approved

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	60 tablet
Strength	500 mg-50 mg
Per unit^*	$5.50
Cost^*	$330.24

View all Janumet prices

Quantity	100 each
Strength	500 mg
Per unit^*	$0.10 - $0.11
Cost^*	$10.00 - $10.79

View all Metformin prices

Quantity	1.5 mL
Strength	2 mg/1.5 mL (0.25 mg or 0.5 mg dose)
Per unit^*	$654.89
Cost^*	$982.34

View all Ozempic prices

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Dosage Forms

Oral tablet

Oral solution
Oral tablet
Oral tablet, extended release

Subcutaneous solution

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

17.6 hours

4.5 hours

168 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 407 drugs are known to interact with Janumet:

26 major drug interactions (133 brand and generic names)
369 moderate drug interactions (1856 brand and generic names)
12 minor drug interactions (43 brand and generic names)

A total of 380 drugs are known to interact with Metformin:

25 major drug interactions (131 brand and generic names)
346 moderate drug interactions (1806 brand and generic names)
9 minor drug interactions (35 brand and generic names)

A total of 275 drugs are known to interact with Ozempic:

16 major drug interactions (36 brand and generic names)
258 moderate drug interactions (1457 brand and generic names)
1 minor drug interactions (10 brand and generic names)

Alcohol/Food/Lifestyle Interactions

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge... View more

Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more
Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more

Disease Interactions

First Approval Date

March 30, 2007

March 03, 1995

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Janumet uses

Metformin uses

Ozempic uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Janumet Alternatives Compared

See also:

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Basaglar

Novolog

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Further information

Janumet Alternatives Compared

See also:

Further information

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