Comparing Doxepin vs Venlafaxine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxepin	Venlafaxine	Enter another drug to compare

Doxepin

Venlafaxine

Prescription only

Doxepin may be used to treat symptoms associated with anxiety or depression such as fear, guilt, sleep disturbances, tension, and worry. It is devoid of any euphoric effect and not associated with... View more

Prescription only

Venlafaxine is an antidepressant that may also be used for mood disorders and off-label for some other conditions such as hot flashes. It may cause a discontinuation syndrome if abruptly stopped... View more

More about Doxepin

More about Venlafaxine

Ratings & Reviews

Doxepin has an average rating of 6.2 out of 10 from a total of 433 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 34% reported a negative effect.

Venlafaxine has an average rating of 6.5 out of 10 from a total of 2788 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 27% reported a negative effect.

View all 433 reviews

View all 2788 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (15.5%)
Weight gain (7.6%)
Tiredness (6.7%)
Anxiety (6.0%)
Dry mouth (5.5%)
Depression (4.4%)
Brain fog (3.7%)

View all Doxepin side effects

Nausea (14.3%)
Anxiety (11.9%)
Dizziness (9.7%)
Withdrawal (9.3%)
Headaches (8.1%)
Insomnia (7.2%)
Tiredness (6.9%)

View all Venlafaxine side effects

Drug Class

Serotonin-norepinephrine reuptake inhibitors

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	50 mg
Per unit^*	$0.93
Cost^*	$92.60

View all Doxepin prices

Quantity	50 each
Strength	75 mg
Per unit^*	$0.35
Cost^*	$17.61

View all Venlafaxine prices

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Dosage Forms

Oral capsule
Oral concentrate
Oral tablet

Oral capsule, extended release
Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

25 hours

4 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 704 drugs are known to interact with Doxepin:

143 major drug interactions (603 brand and generic names)
536 moderate drug interactions (2164 brand and generic names)
25 minor drug interactions (159 brand and generic names)

A total of 701 drugs are known to interact with Venlafaxine:

152 major drug interactions (593 brand and generic names)
544 moderate drug interactions (2377 brand and generic names)
5 minor drug interactions (15 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using doxepin together with alcohol, this can alter the effects of doxepin... View more

Alcohol can increase the nervous system side effects of venlafaxine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

September 23, 1969

December 28, 1993

WADA Class View classifications

N/A

More Information

Patient Resources

Venlafaxine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Doxepin vs Venlafaxine

See also:

Vraylar

Xolair

Rexulti

Lexapro

Abilify

Zoloft

Seroquel

Xanax

Prozac

Cymbalta

Further information

Comparing Doxepin vs Venlafaxine

See also:

Further information

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