Comparing Doxepin vs Hydroxyzine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Doxepin	Hydroxyzine	Enter another drug to compare

Doxepin

Hydroxyzine

Prescription only

Doxepin may be used to treat symptoms associated with anxiety or depression such as fear, guilt, sleep disturbances, tension, and worry. It is devoid of any euphoric effect and not associated with... View more

Prescription only

Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while... View more

More about Doxepin

More about Hydroxyzine

Ratings & Reviews

Doxepin has an average rating of 6.2 out of 10 from a total of 433 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 34% reported a negative effect.

Hydroxyzine has an average rating of 5.9 out of 10 from a total of 1411 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 35% reported a negative effect.

View all 433 reviews

View all 1411 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (15.5%)
Weight gain (7.6%)
Tiredness (6.7%)
Anxiety (6.0%)
Dry mouth (5.5%)
Depression (4.4%)
Brain fog (3.7%)

View all Doxepin side effects

Drowsiness (21.8%)
Tiredness (10.5%)
Sleepy (6.3%)
Anxiety (5.6%)
Nausea (3.8%)
Dizziness (3.7%)
Dry mouth (3.0%)

View all Hydroxyzine side effects

Drug Class

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	50 mg
Per unit^*	$0.48
Cost^*	$47.69

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Quantity	4 tablet
Strength	hydrochloride 25 mg
Per unit^*	$1.18
Cost^*	$4.72

View all Hydroxyzine prices

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Dosage Forms

Oral capsule
Oral concentrate
Oral tablet

Intramuscular solution
Oral capsule
Oral syrup
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

25 hours

7 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category N Not classified

See the full pregnancy warnings document.

Drug Interactions

A total of 705 drugs are known to interact with Doxepin:

144 major drug interactions (607 brand and generic names)
537 moderate drug interactions (2169 brand and generic names)
24 minor drug interactions (157 brand and generic names)

A total of 582 drugs are known to interact with Hydroxyzine:

94 major drug interactions (370 brand and generic names)
484 moderate drug interactions (1995 brand and generic names)
4 minor drug interactions (16 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using doxepin together with alcohol, this can alter the effects of doxepin... View more

Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

September 23, 1969

April 12, 1956

WADA Class View classifications

N/A

More Information

Patient Resources

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Doxepin vs Hydroxyzine

See also:

Vraylar

Xolair

Rexulti

Auvelity

Ativan

Benadryl

Ambien

Lunesta

Ramelteon

Eszopiclone

Further information

Comparing Doxepin vs Hydroxyzine

See also:

Further information

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