Comparing Diphenhydramine vs Promethazine DM
Diphenhydramine | Promethazine DM |
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Diphenhydramine | Promethazine DM (dextromethorphan / promethazine) |
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Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Prescription only
Prescribed for Cough, Allergic Rhinitis, Cold Symptoms. Promethazine DM may also be used for purposes not listed in this medication guide. |
Related suggestions Allergic Rhinitis
Cold Symptoms
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More about Diphenhydramine | More about Promethazine DM (dextromethorphan / promethazine) | ||||||||
Ratings & Reviews | |||||||||
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 529 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 41% reported a negative effect. |
Promethazine DM has an average rating of 5.5 out of 10 from a total of 40 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 44% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
See also: diphenhydramine side effects in more detail. |
See also: Promethazine DM side effects in more detail. |
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Generic Availability | |||||||||
Lower cost generic |
N/A |
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Pricing and Coupons * Prices are without insurance | |||||||||
View all diphenhydramine prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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Dosage Forms Available | |||||||||
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Brand Names | |||||||||
Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more |
N/A |
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Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
9.3 hours |
16 hours |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||
A total of 448 drugs are known to interact with diphenhydramine:
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A total of 730 drugs are known to interact with Promethazine DM:
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Alcohol/Food/Lifestyle Interactions | |||||||||
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Disease Interactions | |||||||||
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First Approval Date | |||||||||
March 04, 1946 |
February 14, 2006 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
Related Treatment Guide | |||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.