Promethazine DM (dextromethorphan / promethazine) Drug Interactions
A total of 670 drugs are known to interact with Promethazine DM (dextromethorphan / promethazine).
- 106 major drug interactions
- 549 moderate drug interactions
- 15 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for Promethazine DM (dextromethorphan / promethazine) and the medicines listed below.
- albuterol
- amoxicillin
- Benadryl (diphenhydramine)
- cyclobenzaprine
- doxycycline
- fluticasone nasal
- gabapentin
- ibuprofen
- levothyroxine
- lisinopril
- metformin
- montelukast
- omeprazole
- prednisone
- ProAir HFA (albuterol)
- tizanidine
- tramadol
- trazodone
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
Promethazine DM (dextromethorphan / promethazine) alcohol/food interactions
There is 1 alcohol/food interaction with Promethazine DM (dextromethorphan / promethazine)
Promethazine DM (dextromethorphan / promethazine) disease interactions
There are 19 disease interactions with Promethazine DM (dextromethorphan / promethazine) which include:
- acute alcohol intoxication
- cardiovascular disease
- CNS depression
- head injury
- antidopaminergic effects 1
- asthma
- anticholinergic effects
- asthma/COPD
- psychiatric conditions
- breast cancer
- dystonic reactions
- hematologic toxicity
- liver disease
- NMS
- parkinsonism
- renal dysfunction
- seizure disorders
- tardive dyskinesia
- antidopaminergic effects 2
More about Promethazine DM (dextromethorphan / promethazine)
- Side Effects
- During Pregnancy
- Dosage Information
- 15 Reviews
- Drug class: upper respiratory combinations
- FDA Alerts (1)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.