Diphenhydramine / phenylephrine Alternatives Compared
| Diphenhydramine / phenylephrine | Zyrtec (cetirizine) | Cetirizine |
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| Diphenhydramine / phenylephrine | Zyrtec (cetirizine) | Cetirizine |
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Prescription and OTC
Prescribed for Sinusitis, Allergic Rhinitis, Cold Symptoms. Diphenhydramine / phenylephrine may also be used for purposes not listed in this medication guide. |
Prescription and OTC
Zyrtec is used to temporarily relieve symptoms due to hay fever or other upper respiratory allergies such as a runny nose, sneezing, itchy or watery eyes, or itching of the nose or throat. It is a... View more |
Prescription and OTC
Cetirizine is a second-generation antihistamine that is used to treat symptoms of perennial allergic rhinitis, chronic urticaria (hives), and is also effective at controlling symptoms such as... View more |
Related suggestions Allergic Rhinitis
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| More about Diphenhydramine / phenylephrine | More about Zyrtec (cetirizine) | More about Cetirizine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Diphenhydramine / phenylephrine has an average rating of 10.0 out of 10 from a total of 1 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
Zyrtec has an average rating of 5.7 out of 10 from a total of 199 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 36% reported a negative effect. |
Cetirizine has an average rating of 5.8 out of 10 from a total of 296 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 36% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
View all Zyrtec side effects |
View all Cetirizine side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
Lower cost generic approved |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zyrtec prices |
View all Cetirizine prices |
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| Dosage Forms | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
| Alahist LQ, Aldex-CT, Benadryl Allergy Plus Congestion, Benadryl Children's Allergy Plus Congestion, Benadryl-D Allergy Plus Sinus, Benadryl-D Children's Allergy & Sinus, Children's Triacting Night Time, D-Tann, Delsym Children's Night Time Cough & Cold, Dimetapp Children's Nighttime Cold & Congestion, Dimetapp Nighttime Cold and Congestion, Diphenmax D, Diphentann-D, Dytan-D, PediaCare Nighttime Multi-Symptom Cold, Pediatex-CT, Robitussin Night Time Cough & Cold, Sudafed PE Sinus Congestion Nighttime, Triaminic Night Time Cold & Cough View more | Other cetirizine brands include: All Day Allergy, All Day Allergy Children's, Aller-Tec, Aller-Tec Children's, Alleroff, Children's Allergy Relief, Equate Allergy Relief, PediaCare Children's 24-Hour Allergy, Quzyttir, Zyrtec Hives View more | All Day Allergy, All Day Allergy Children's, Aller-Tec, Aller-Tec Children's, Alleroff, Children's Allergy Relief, Equate Allergy Relief, PediaCare Children's 24-Hour Allergy, Quzyttir, Zyrtec, Zyrtec Hives View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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9.3 hours |
10.6 hours |
10.6 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 577 drugs are known to interact with Diphenhydramine / phenylephrine:
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A total of 254 drugs are known to interact with Zyrtec:
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A total of 254 drugs are known to interact with Cetirizine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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N/A |
N/A |
December 08, 1995 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
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N/A |
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| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.