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Diphenhydramine / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on Jul 22, 2019.

Applies to the following strengths: 6.25 mg-2.5 mg/5 mL; 6.25 mg-6.25 mg/5 mL; 12.5 mg-5 mg; 25 mg-7.5 mg/5 mL; 25 mg-10 mg; 12.5 mg-5 mg/5 mL

Usual Adult Dose for Allergic Rhinitis

Diphenhydramine 12.5 mg / phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Diphenhydramine 25 mg / phenylephrine 10 mg per tablet: 1 tablet every 4 hours
Maximum dose: 6 doses per 24 hours

Usual Adult Dose for Cold Symptoms

Diphenhydramine 12.5 mg / phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Diphenhydramine 25 mg / phenylephrine 10 mg per tablet: 1 tablet every 4 hours
Maximum dose: 6 doses per 24 hours

Usual Pediatric Dose for Allergic Rhinitis

Diphenhydramine 6.25 mg / phenylephrine 2.5 mg per 5 mL liquid:
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Diphenhydramine 12.5 mg / phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Diphenhydramine 25 mg / phenylephrine 10 mg per tablet:
12 years and older: 1 tablet every 4 hours
Maximum dose: 6 doses per 24 hours

Usual Pediatric Dose for Cold Symptoms

Diphenhydramine 6.25 mg / phenylephrine 2.5 mg per 5 mL liquid:
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Diphenhydramine 12.5 mg / phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 6 doses per 24 hours

Diphenhydramine 25 mg / phenylephrine 10 mg per tablet:
12 years and older: 1 tablet every 4 hours
Maximum dose: 6 doses per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
-Concomitant use with any other diphenhydramine-containing products, including topical preparations.

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Use provided measuring cups for dosing.


Patient advice:
-Take only as directed.
-Avoid drinking alcohol while on this drug.
-Discontinue for nervousness, dizziness, or sleepiness.
-Use caution if driving a motor vehicle or operating machinery.
-If symptoms last over 7 days or are accompanied by fever, seek medical attention.
-If cough lasts over 7 days or comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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