Diphenhydramine / Phenylephrine Dosage

Medically reviewed on August 1, 2017.

Usual Adult Dose for Allergic Rhinitis

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Adult Dose for Cold Symptoms

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Adult Dose for Sinusitis

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Pediatric Dose for Allergic Rhinitis

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue

Usual Pediatric Dose for Cold Symptoms

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue

Usual Pediatric Dose for Sinusitis

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer