Diphenhydramine / Phenylephrine Dosage
Applies to the following strengths: 6.25 mg-2.5 mg/5 mL; 6.25 mg-6.25 mg/5 mL; 12.5 mg-5 mg; 25 mg-7.5 mg/5 mL; 25 mg-10 mg; 12.5 mg-5 mg/5 mL
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Allergic Rhinitis
diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours
Usual Adult Dose for Cold Symptoms
diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours
Usual Adult Dose for Sinusitis
diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours
Usual Pediatric Dose for Allergic Rhinitis
diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours
diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours
diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue
Usual Pediatric Dose for Cold Symptoms
diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours
diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours
diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue
Usual Pediatric Dose for Sinusitis
diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours
diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.
diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours
diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dialysis
Data not available
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about diphenhydramine/phenylephrine
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- Dosage Information
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- Drug class: upper respiratory combinations
Consumer resources
- Diphenhydramine and phenylephrine
- Diphenhydramine/Phenylephrine Chewable Tablets
- Diphenhydramine and Phenylephrine Liquid, Solution, and Syrup
- Diphenhydramine and Phenylephrine Oral Strips
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