Diphenhydramine / Phenylephrine Dosage
Medically reviewed by Drugs.com. Last updated on Jul 22, 2019.
Applies to the following strengths: 6.25 mg-2.5 mg/5 mL; 6.25 mg-6.25 mg/5 mL; 12.5 mg-5 mg; 25 mg-7.5 mg/5 mL; 25 mg-10 mg; 12.5 mg-5 mg/5 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Allergic Rhinitis
Diphenhydramine 12.5 mg / phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Diphenhydramine 25 mg / phenylephrine 10 mg per tablet: 1 tablet every 4 hours
Maximum dose: 6 doses per 24 hours
Usual Adult Dose for Cold Symptoms
Diphenhydramine 12.5 mg / phenylephrine 5 mg per 10 mL liquid: 20 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Diphenhydramine 25 mg / phenylephrine 10 mg per tablet: 1 tablet every 4 hours
Maximum dose: 6 doses per 24 hours
Usual Pediatric Dose for Allergic Rhinitis
Diphenhydramine 6.25 mg / phenylephrine 2.5 mg per 5 mL liquid:
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Diphenhydramine 12.5 mg / phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Diphenhydramine 25 mg / phenylephrine 10 mg per tablet:
12 years and older: 1 tablet every 4 hours
Maximum dose: 6 doses per 24 hours
Usual Pediatric Dose for Cold Symptoms
Diphenhydramine 6.25 mg / phenylephrine 2.5 mg per 5 mL liquid:
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Diphenhydramine 12.5 mg / phenylephrine 5 mg per 10 mL liquid:
12 years and older: 20 mL every 4 hours
6 to under 12 years: 10 mL every 4 hours
Maximum dose: 6 doses per 24 hours
Diphenhydramine 25 mg / phenylephrine 10 mg per tablet:
12 years and older: 1 tablet every 4 hours
Maximum dose: 6 doses per 24 hours
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
-Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
-Concomitant use with any other diphenhydramine-containing products, including topical preparations.
Safety and efficacy have not been established in patients younger than 6 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
-Use provided measuring cups for dosing.
Patient advice:
-Take only as directed.
-Avoid drinking alcohol while on this drug.
-Discontinue for nervousness, dizziness, or sleepiness.
-Use caution if driving a motor vehicle or operating machinery.
-If symptoms last over 7 days or are accompanied by fever, seek medical attention.
-If cough lasts over 7 days or comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about diphenhydramine / phenylephrine
- Side Effects
- During Pregnancy
- Drug Images
- Drug Interactions
- En Español
- 1 Review
- Drug class: upper respiratory combinations
- FDA Alerts (1)
Consumer resources
- Diphenhydramine and phenylephrine
- Diphenhydramine and Phenylephrine Liquid, Solution, and Syrup
- Diphenhydramine and Phenylephrine Oral Strips
Other brands: Triaminic Night Time Cold & Cough, Alahist LQ, Children's Triacting Night Time, Delsym Children's Night Time Cough & Cold, ... +5 more
