Diphenhydramine/phenylephrine Interactions
There are 576 drugs known to interact with diphenhydramine/phenylephrine, along with 12 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 42 are major, 531 are moderate, and 3 are minor.
- View all 576 medications that may interact with diphenhydramine/phenylephrine
- View diphenhydramine/phenylephrine alcohol/food interactions (2)
- View diphenhydramine/phenylephrine disease interactions (12)
Most frequently checked interactions
View interaction reports for diphenhydramine / phenylephrine and the medicines listed below.
- Advil (ibuprofen)
- Allegra (fexofenadine)
- Ativan (lorazepam)
- Azo-Cranberry (cranberry)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- Claritin-D (loratadine / pseudoephedrine)
- Copper (copper gluconate)
- Depakote (divalproex sodium)
- Fioricet (acetaminophen / butalbital / caffeine)
- Flonase (fluticasone nasal)
- Low Dose ASA (aspirin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Midol Complete (acetaminophen / caffeine / pyrilamine)
- MiraLAX (polyethylene glycol 3350)
- Mucinex D (guaifenesin / pseudoephedrine)
- Mucinex DM (dextromethorphan / guaifenesin)
- Mucinex Sinus-Max Pressure & Pain (acetaminophen / guaifenesin / phenylephrine)
- Paxlovid (nirmatrelvir / ritonavir)
- Pepto-Bismol (bismuth subsalicylate)
- Percocet 5 / 325 (acetaminophen / oxycodone)
- Phenergan (promethazine)
- Prilosec (omeprazole)
- ProAir HFA (albuterol)
- Singulair (montelukast)
- Vitamin D3 (cholecalciferol)
- Zofran (ondansetron)
- Zyrtec (cetirizine)
Diphenhydramine/phenylephrine alcohol/food interactions
There are 2 alcohol/food interactions with diphenhydramine / phenylephrine.
Diphenhydramine/phenylephrine disease interactions
There are 12 disease interactions with diphenhydramine / phenylephrine which include:
- depression
- cardiovascular disease
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- BPH
- diabetes
- glaucoma
Report options
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More about diphenhydramine / phenylephrine
- diphenhydramine/phenylephrine consumer information
- Compare alternatives
- Reviews (1)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
