Diphenhydramine/phenylephrine Interactions
There are 577 drugs known to interact with diphenhydramine/phenylephrine, along with 12 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 42 are major, 532 are moderate, and 3 are minor.
- View all 577 medications that may interact with diphenhydramine/phenylephrine
- View diphenhydramine/phenylephrine alcohol/food interactions (2)
- View diphenhydramine/phenylephrine disease interactions (12)
Most frequently checked interactions
View interaction reports for diphenhydramine / phenylephrine and the medicines listed below.
- Advil (ibuprofen)
- Allegra (fexofenadine)
- Ativan (lorazepam)
- Azo-Cranberry (cranberry)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- Claritin-D (loratadine / pseudoephedrine)
- Copper (copper gluconate)
- Depakote (divalproex sodium)
- Fioricet (acetaminophen / butalbital / caffeine)
- Flonase (fluticasone nasal)
- Low Dose ASA (aspirin)
- Lyrica (pregabalin)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Midol Complete (acetaminophen / caffeine / pyrilamine)
- MiraLAX (polyethylene glycol 3350)
- Mucinex D (guaifenesin / pseudoephedrine)
- Mucinex DM (dextromethorphan / guaifenesin)
- Mucinex Sinus-Max Pressure & Pain (acetaminophen / guaifenesin / phenylephrine)
- Paxlovid (nirmatrelvir / ritonavir)
- Pepto-Bismol (bismuth subsalicylate)
- Percocet 5 / 325 (acetaminophen / oxycodone)
- Phenergan (promethazine)
- Prilosec (omeprazole)
- ProAir HFA (albuterol)
- Singulair (montelukast)
- Vitamin D3 (cholecalciferol)
- Zofran (ondansetron)
- Zyrtec (cetirizine)
Diphenhydramine/phenylephrine alcohol/food interactions
There are 2 alcohol/food interactions with diphenhydramine / phenylephrine.
Diphenhydramine/phenylephrine disease interactions
There are 12 disease interactions with diphenhydramine / phenylephrine which include:
- depression
- cardiovascular disease
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- BPH
- diabetes
- glaucoma
Report options
More about diphenhydramine / phenylephrine
- diphenhydramine/phenylephrine consumer information
- Compare alternatives
- Reviews (1)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Cetirizine
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Ozempic
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Ciprofloxacin
Ciprofloxacin is an antibiotic belong to a group of drugs called fluoroquinolones. Learn about side ...
Montelukast
Montelukast is a daily oral medication used to prevent asthma attacks, exercise-induced ...
Azithromycin
Azithromycin is an antibiotic used to treat many different types of infections caused by bacteria ...
Fluticasone nasal
Fluticasone nasal is used for allergic rhinitis, allergies, chronic rhinosinusitis with nasal ...
Augmentin
Augmentin is a prescription antibiotic combining amoxicillin and clavulanate to treat bacterial ...
Loratadine
Loratadine is a non-drowsy antihistamine used to relieve allergy symptoms like sneezing, runny ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
