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Diphen Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Diphen Benadryl Diphenhydramine
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Diphen (diphenhydramine) Benadryl (diphenhydramine) Diphenhydramine
Prescription and OTC

Prescribed for Allergic Reactions, Allergic Rhinitis, Cold Symptoms, Cough, Extrapyramidal Reaction, Motion Sickness, Nausea/Vomiting, Pruritus, Urticaria. Diphen may also be used for purposes not... View more

Prescription and OTC

Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... View more

Prescription and OTC

Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more

More about (diphenhydramine) More about Benadryl (diphenhydramine) More about Diphenhydramine
Ratings & Reviews

Diphen has an average rating of 10.0 out of 10 from a total of 1 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect.

Benadryl has an average rating of 7.2 out of 10 from a total of 77 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 19% reported a negative effect.

Diphenhydramine has an average rating of 5.5 out of 10 from a total of 530 ratings on Drugs.com. 43% of reviewers reported a positive effect, while 41% reported a negative effect.

View all 1 reviews

View all 77 reviews

View all 530 reviews

Drug Class
Side Effects

See also: Diphen side effects in more detail.

See also: Benadryl side effects in more detail.

See also: diphenhydramine side effects in more detail.
Generic Availability

N/A

N/A

Lower cost generic
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 24 tablet
Dosage 25 mg
Per Unit* $0.42
Cost* $9.99

View all Benadryl prices

Quantity 12 each
Dosage 25 mg
Per Unit* $0.95
Cost* $11.37

View all diphenhydramine prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Forms Available
  • Oral liquid
  • Oral capsule
  • Oral tablet
  • Injectable solution
  • Oral capsule
  • Oral liquid
  • Oral tablet
  • Oral tablet, chewable
Brand Names
Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

9.3 hours

9.3 hours

9.3 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
B
Category B No proven risk in humans

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
Drug Interactions

A total of 448 drugs are known to interact with Diphen:

  • 14 major drug interactions (90 brand and generic names)
  • 432 moderate drug interactions (1671 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)

A total of 448 drugs are known to interact with Benadryl:

  • 14 major drug interactions (90 brand and generic names)
  • 432 moderate drug interactions (1671 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)

A total of 448 drugs are known to interact with diphenhydramine:

  • 14 major drug interactions (90 brand and generic names)
  • 432 moderate drug interactions (1671 brand and generic names)
  • 2 minor drug interactions (8 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using diphenhydrAMINE together with alcohol. Use alcohol cautiously... View more
  • Ask your doctor before using diphenhydrAMINE together with alcohol. Use alcohol cautiously... View more
  • Ask your doctor before using diphenhydrAMINE together with alcohol. Use alcohol cautiously... View more
Disease Interactions
First Approval Date

N/A

March 04, 1946

March 04, 1946
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources

N/A
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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