Comparing Cetirizine vs Diphenhydramine
| Cetirizine | Diphenhydramine |
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| Cetirizine | Diphenhydramine |
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Prescription and OTC
Cetirizine is an antihistamine that effectively treats allergic reactions such as hay fever or skin reactions caused by insect bites. Although drowsiness with cetirizine is uncommon, cetirizine is... View more |
Prescription and OTC
Diphenhydramine is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side... View more |
Related suggestions Allergic Rhinitis
Urticaria
Allergies
Eustachian Tube Dysfunction
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| More about Cetirizine | More about Diphenhydramine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Cetirizine has an average rating of 5.8 out of 10 from a total of 295 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 36% reported a negative effect. |
Diphenhydramine has an average rating of 5.5 out of 10 from a total of 546 ratings on Drugs.com. 42% of reviewers reported a positive effect, while 40% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Cetirizine side effects |
View all Diphenhydramine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Cetirizine prices |
View all Diphenhydramine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| All Day Allergy, All Day Allergy Children's, Aller-Tec, Aller-Tec Children's, Alleroff, Children's Allergy Relief, Equate Allergy Relief, PediaCare Children's 24-Hour Allergy, Quzyttir, Zyrtec, Zyrtec Hives View more | Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep, ZzzQuil View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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10.6 hours |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 254 drugs are known to interact with Cetirizine:
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A total of 449 drugs are known to interact with Diphenhydramine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 08, 1995 |
March 04, 1946 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Zyrtec
Zyrtec (cetirizine) is used to treat allergy symptoms such as sneezing, itching, watery eyes, or ...
Benadryl
Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other ...
Xolair
Xolair injection (omalizumab) is used to help improve allergic asthma, nasal polyps, and chronic ...
Claritin
Claritin is an antihistamine used to treat the symptoms of allergies, such as sneezing, watery ...
Dupixent
Dupixent is used to treat eczema, eosinophilic or oral-corticosteroid-dependent asthma, chronic ...
Levocetirizine
Levocetirizine is an antihistamine that may be used to reduce allergy symptoms such as red, itchy ...
Fexofenadine
Fexofenadine is an antihistamine that may be used to treat allergies.
Doxepin
Doxepin is used for anxiety, depression, insomnia, irritable bowel syndrome, major depressive ...
Promethazine
Promethazine is a phenothiazine and antihistamine used to treat allergies, motion sickness, nausea ...
Diphenhydramine
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.