Comparing Caplyta vs Invega Sustenna

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Caplyta lumateperone

Invega Sustenna paliperidone

Caplyta is an atypical antipsychotic that may be used to treat adults with schizophrenia. Sedation is the most common side effect and it should not be used in people with moderate to severe liver... View more

Prescribed for Schizoaffective Disorder, Schizophrenia. Invega Sustenna may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

View all 27 reviews

View all 127 reviews

Drug Class

Atypical antipsychotics

Atypical antipsychotics

Side Effects

See the full Caplyta side effects document.

See the full Invega Sustenna side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 each
Dosage	42 mg
Per Unit^*	$49.01
Cost^*	$1,470.26

View all Caplyta prices

Quantity	0.25 mL
Dosage	39 mg/0.25 mL
Per Unit^*	$2,084.12
Cost^*	$521.03

View all Invega Sustenna prices and generic prices

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Generic Availability

Yes

Dosage Form(s) Available

Oral capsule

Intramuscular suspension, extended release

Brand Names

N/A

Other paliperidone brands include: Invega, Invega Trinza

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

18 hours

23 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Summary unavailable.

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

N/A

FDA Alerts (3)

Drug Interactions

A total of 543 drugs are known to interact with Caplyta:

137 major drug interactions (546 brand and generic names)
405 moderate drug interactions (1581 brand and generic names)
1 minor drug interactions (3 brand and generic names)

A total of 587 drugs are known to interact with Invega Sustenna:

88 major drug interactions (334 brand and generic names)
496 moderate drug interactions (2010 brand and generic names)
3 minor drug interactions (14 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Grapefruit and grapefruit juice may increase the blood levels of lumateperone. In some cases, this... View more
Using lumateperone together with alcohol may increase side effects such as dizziness, drowsiness,... View more

You should avoid the use of alcohol while being treated with paliperidone. Alcohol can increase... View more

Disease Interactions

First Approval Date

December 20, 2019

July 31, 2009

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer