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Invega Sustenna and Weight Gain: What Users Say

Weight gain: mentioned by 64 users (33.3%)

Based on user experiences from 192 Invega Sustenna reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

weight gain 33.3%
depression 21.9%
sexual dysfunction 15.6%
hallucinations 12.0%
tiredness 9.4%
anxiety 8.9%
memory loss 6.8%
insomnia 6.3%
dizziness 4.7%
fatigue 4.7%

Reviews for Invega Sustenna

Commonly mentioned side effects
  • Sad...
  • Taken for 1 to 2 years
  • April 17, 2021

For Schizoaffective Disorder "I was prescribed Invega Sustenna on my 5th hospital stay for bipolar and schizoaffective episodes. I wasn’t responding to the oral medications, and I have compliance issues with taking oral meds anyway. Like most people who have already commented, my experience with this drug has been horrible. Yes, it stopped the hallucinations, but it has robbed me of my emotions. I feel flat all the time, I gained weight, my hair fell out, I lost my sex drive and my ability to orgasm. I have anhedonia and avolition, I cannot socialize anymore, I can barely contribute to a conversation, I’m barely caring for myself (not cooking, not cleaning)... I am like a child. This medication is terrible in my opinion, I would not recommend it. I’d rather live with the occasional hallucination than all of the side effects Invega has caused."

1 / 10
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  • Rem...
  • October 14, 2019

For Schizophrenia "I took 6 injections over a 6-month period. I didn't notice much in the first couple of months. It helped with the paranoia, I still heard voices to a lesser extent. Around the 5th month, I had noticed I gained 50 lbs (115 to 165). It happened so rapidly. I also began to lactate. That was all horrible, but the worst of it was the severe anhedonia. They wanted to slowly taper me off the injection, but I refused to take any more after the 6-month period. I felt mentally slower. I got no pleasure from listening to music or watching TV. I stopped laughing. This is just my personal experience, but if you look up this medicine, you will find there are many people who have gone through a similar experience. It's been 14 months since my last injection, and I think I have mentally fully recovered. I think this drug is too potent. I am almost certain it gave me some sort of brain damage. One of the biggest regrets of my life is taking this drug, I was better off before."

1 / 10
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  • Ean...
  • May 17, 2019

For Schizophrenia "Worst experience of my life. I can't describe all of the side effects I had on Invega Sustenna in 1000 characters, but my mind was disturbingly blank on this medication. It was as if all of my conscious thoughts were gone. I gained 25 pounds even though I just got the initial dose & lost muscle. My delusions did go away so it worked for that, but it felt like it was because my thoughts stopped. I've gotten 4 sprains and one pulled muscle since I got injected with this 'poison' at the end of August last year. My skin started flaking off and my hair was falling out. I couldn't feel any emotions. I was unable to orgasm for the first month. There were more side effects, and I don't think I fully conveyed the desperation I felt on this medication. I would like to let people who have gotten on it and hate it that there is hope and you will get better - once you are off it."

1 / 10
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Frequently asked questions

  • Anonymous
  • Taken for 2 to 5 years
  • September 28, 2020

For Schizophrenia "I've taken this for 3 and a half years and I noticed I have a ridiculously bad memory. I will start a sentence 'I remember this one time,' then I won't know what I was talking about in mid-sentence - I forget what I'm talking about. I don't know if I have a sex drive because I have no partner, and I gained 40 lbs. I don't have an appetite, I don't feel hungry, yet still I'm overweight, probably because my body thinks it's starving and I gain weight when I do eat. I have to make myself eat what feels like gross food even though it's good food. I have no feelings, my emotions are numb. This medication did help my paranoia though. I've become fat and forgetful."

3 / 10
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72 Report
  • bd1...
  • Taken for 1 to 6 months
  • December 15, 2018

For Schizophrenia "If I could rate this medication a 0, I would. Going on this medication was one of the biggest mistakes of my life. I have bipolar I disorder and suffered a severe manic episode that didn’t respond to Seroquel or Risperdal. The psychiatrist prescribed me Invega, and while it got rid of my mania and psychosis, it completely altered my personality. I had absolutely no emotion at all. I did not feel any sort of joy or happiness. Not to mention, I gained at least 20 pounds (I’m a very active 24-year-old). The suicidal thoughts were so severe that I needed to be hospitalized. The absolute worst part is that even when you stop Invega, it stays in your system for months. It has an extremely long half-life. If you want to be a zombie and lose interest in everything you ever loved, then take this medicine. If you’d like to be a productive member of society, avoid this medication at all costs. Find another medicine."

1 / 10
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  • Bae...
  • Taken for 1 to 6 months
  • September 3, 2020

For Schizophrenia "Where do I start with the side effects of Invega Sustenna? Sexual dysfunction, yes, my penis is useless, I feel like a 2-year-old. I have severe anhedonia (loss of pleasure), I have put on 20 kg, I sleep for 11-12 hours a day, and just overall feel terrible. My memory is horrible, I’m depressed, and I just feel like I am not living some days. Whatever you do, do not take this drug. Other antipsychotic drugs are better, they don’t all have the same effects, so just try aiming elsewhere."

1 / 10
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  • Blk...
  • Taken for 1 to 6 months
  • October 30, 2019

For Schizophrenia "The one positive effect of this drug (Invega Sustenna 150 mg every 4 weeks) is that it controls my hallucinations and delusions. But the trade-off is really hard to bear. I’ve lost all the joy in my life, the anhedonia is so bad that I have to live in a constant state of pretending to be happy because I am now unable to feel any kind of happiness or pleasure, especially from activities I once enjoyed very much. I can’t recall things and my memories have evaporated. I feel blunted and flat all the time. I can’t function in a meaningful way, and feel more depressed than I ever have in my life. I’ve gained lots of weight, lost muscle tone, yet I feel agitated like I want to jump out of my skin all the time. Being on this medication is a living nightmare. I am 43 and feel like life has come to a screeching halt."

3 / 10
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More FAQ

  • Jid...
  • Taken for 1 to 2 years
  • October 9, 2021

For Schizophrenia "I was misdiagnosed due to an incident. Ever since I got this injection, I’ve been feeling less of myself. I’ve gained weight, at least 90 lbs, no emotion, barely sleep at night (5 hours), foggy mind, can’t think, bad concentration, less dopamine, shortness of breath, no creativity, and no personality. What’s the point of having a medicine that has worse side effects than the problem?"

1 / 10
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  • NKa...
  • November 18, 2019

For Schizoaffective Disorder "At first, it didn't seem that bad taking Invega. I got the shot once a month. I was in the psych ward for paranoia and delusions. Hallucinations had subsided. They told me they would hold me at the V.A. for four months if I didn't take the shot. They used psychological manipulation to get me to 'agree.' Six months later, I'm 60 lbs overweight, depressed, and tired beyond belief. All I want to do is lay down and close my eyes. Today I woke up about 11:00 a.m., got out of bed for an hour, went and laid back down till about 4 p.m., then got up to make myself something to eat, then laid down till 6, got up for another hour, then right back to bed. This is my daily routine on this nightmarish drug. I'm taking one class in school and can't afford to withdraw off of it right now, but in a month I will graduate and finally get off this terrible drug forever. It makes me want to do nothing in life, nor could I work taking this medication. It has ruined a year of my life. I'd rather have symptoms."

1 / 10
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  • bec...
  • Taken for 2 to 5 years
  • March 23, 2020

For Schizoaffective Disorder "I've been on this drug Invega Sustenna for the last 5 years. I've gained 65 lbs, I'm 5'4" tall. I'm restless, have liver problems, memory problems. I don't know which symptoms it is treating. I do not hallucinate. I originally got diagnosed with bipolar disorder 23 years ago because I could not sleep at night. This drug is horrible, and there are no benefits from it."

1 / 10
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55 Report
  • Yes...
  • March 11, 2019

For Schizophrenia "This medicine is horrible. Every time I take it, I am unable to work out. I can't even run a mile, I am so weak. I get restless leg syndrome, fatigue, weight gain, and blurred vision. I'm done taking medicine, sick of it."

1 / 10
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53 Report
  • Lew...
  • December 22, 2019

For Schizophrenia "I now have a deadly and nontreatable heart condition called a Left Anterior Fascicular Block (LAFB) due to overprescribed high doses of Invega and not being diagnosed 3 years in a row with hyperlipidemia (high cholesterol and extremely high triglycerides) and hyperprolactinemia (abnormal hormones causing loss of erection and sperm production) and 'reduced function' stage 2 kidney damage, as well as 65 lbs weight gain, none of which was diagnosed or referred to a PCP for treatment. Now I am without a treatment plan, and my fate is sealed. Bad drug period."

1 / 10
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  • Poo...
  • Taken for less than 1 month
  • October 30, 2019

For Schizoaffective Disorder "I think this is a terrible drug. DO NOT TAKE. Causes schizophrenia, does not treat it. I repeat, do not take. Will decrease your thinking to almost not there completely. Will remove your emotions almost completely. Side effects on top of side effects. Weight gain, blurry vision, restless leg syndrome, brain pain, and more. Do not take even if the doctor convinces you it is a good idea. It is not a good idea at all."

1 / 10
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45 Report
  • Ela...
  • Taken for 2 to 5 years
  • May 19, 2018

For Schizoaffective Disorder "Well, now I now know why they call psychiatrists 'shrinks.' I have been on this drug for years. I have tried taking vitamins and eating healthy to stay well and still gained 50 pounds. I have far too many headaches and sleep all day. I think they finally did it - they shrunk my brain!"

1 / 10
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50 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • December 14, 2018

For Schizophrenia "I started taking this medication as a monthly injection for hearing voices/paranoia, and I took it for about 6 months. It made me gain 40 lbs, I lost all sex drive, my mind became foggy, and I felt mentally slower. I also got severe anhedonia and became unable to feel the effects of alcohol and cigarettes. I don't recommend this medication to anyone. I've been off it for 4 months and am still dealing with the side effects of this medication. I will say that it did reduce the voices significantly, but only because it's such a powerful mind-numbing drug. I would advise trying something else if you really need a medication. Basically, a chemical lobotomy."

2 / 10
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46 Report
  • Jun...
  • Taken for 1 to 6 months
  • February 3, 2019

For Schizoaffective Disorder "If you want your life back and want to finally quit hearing the voices, believing the delusions that persist in your head and just be able to live a “normal” life, then this medication is absolutely for you. You will overeat, gain a little weight, have restless nights, and sleep all afternoon, you will have restless leg syndrome where you just can’t sit still. It takes about a month and a half for side effects to diminish. I’m so thankful to finally be happy again and be able to hold down a job. Those dark voices are gone. I don’t read a news article and believe I spoke to the President of the United States personally anymore. Now I wake up every day with just a calm, happy persona both internally and externally. The best part is that it’s only a once-a-month injection. I’ll tell you that on the day of the shot I do still get a little dizzy and tired, so I usually request off the entire day so I can relax. But even my family has noticed the huge change in me."

10 / 10
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  • Fin...
  • Taken for 5 to 10 years
  • July 24, 2019

For Schizoaffective Disorder "I was in denial about my illness for about 8 years before I finally went to the hospital by police escort (with the help of my family). I had lost my marriage, couldn’t do my job, and I couldn’t figure out why all this was happening to me. The doctor at the hospital ordered the Invega Sustenna injection, and it completely turned my life around. 5 years later, I’m in a great relationship, and I’ve been able to go back to school, earning A’s in my classes. People like me again. I did try to go off of the medication last year with the help of my doctor to see if having children would be possible. We have to do more homework on our options because I was only able to stay off for 6 months after the taper. For me, I’m very thankful for this medication. Yes, I gained 20 pounds, but that isn’t terrible when I consider that I’m no longer hurting the people who care about me."

10 / 10
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50 Report
  • Yus...
  • December 22, 2019

For Schizophrenia "Gained 40 lbs in two weeks right after taking it. Made me pale (I'm olive complexion). Made anxiety horrible for a few months (could not stop moving around). Messed up sleeping habits for a few months. Stopped my periods for three months in a row. Never had problems with any of these things before taking. Been off for ten months now, just now getting back to close to normal."

2 / 10
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36 Report
  • Dar...
  • Taken for 5 to 10 years
  • February 24, 2021

For Schizophrenia "Miserable all the time on these Invega injections from several side effects. I'm mentally blank like poverty in thoughts. I'll sit around a lot staring at TV while mindless. I have no emotions except anxiety and akathisia, which is chronic restlessness. I take Inderal blood pressure medication to treat akathisia. Feel like an emotionless robot going through the motions and barely alive. Poor memory, focus, learning, and concentration. Feel physically numb. Gained 40 pounds. No sex drive and no libido. No interest and motivation to do anything."

1 / 10
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27 Report
  • Ano...
  • Taken for 1 to 2 years
  • June 7, 2018

For Schizoaffective Disorder "I feel like this medication has ruined my life completely because I ended up gaining weight, having prediabetes, and not having my period for 2 years. My biggest concern is am I gonna be able to have children when I get older. I decided that I rather stop taking this medication because it can ruin your future."

2 / 10
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40 Report
  • She...
  • Taken for 6 months to 1 year
  • July 4, 2019

For Schizoaffective Disorder "Horrible drug, causes weight gain. I call it the '15 lbs shot', with every shot, I gained another 15 lbs. My hallucinations went into overdrive, I could not sleep, depressed, angry, overweight, psychotic, hated every day. I am now seeing a new psychiatrist, and I am getting my life back without the Invega Sustenna injection."

2 / 10
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35 Report
  • Coq...
  • Taken for 1 to 2 years
  • November 24, 2021

For Schizoaffective Disorder "I took Invega Sustenna for a year and a half. I was forced on it by my old mental hospital, and the family member I was living with told me I had to stay on Invega to live with this person. I got a 234 mg shot once a month for a year and a half. This drug completely ruined my life. It is absolute garbage for anyone's body. I went from 170 pounds to 300 pounds within this time frame (this is literally the most weight I had ever gained in my entire LIFE.) It turned me into a complete couch potato, made me so lazy and tired that I had to drink at least 3 cups of coffee a day to counter this problem. It completely destroyed my motivation for doing ANYTHING throughout my day. I sat around eating junk food, but also healthy food. Regardless of what I ate, I would gain 10 pounds every single month. I am really tired of the USA and its doctors promoting these awful 'medications' to sick people as if they are good options. There was zero benefit to using Invega, do NOT take this drug."

1 / 10
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  • Str...
  • Taken for 6 months to 1 year
  • November 5, 2018

For Schizophrenia "Invega Sustenna was a horrible experience for me. This medication caused me to gain 20-30 pounds. It stopped my monthly cycles. I was also not able to experience sexual pleasure. This medication ruins lives."

1 / 10
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35 Report
  • Dir...
  • Taken for 1 to 2 years
  • November 20, 2019

For Schizoaffective Disorder "I was placed on Invega Sustenna after having a violent psychotic episode. I attempted suicide in a very violent manner and went back to the psych ward after surgery. They placed me on a 156 mg injection once a month. Since being on the injection, I’ve experienced slight weight gain, loss of euphoria I used to get from using drugs like alcohol, weed, amphetamines, benzodiazepines, and also the inability to “trip” from using psychedelics. Also, loss of sex drive. Most importantly, though... I no longer have the constant thoughts of wanting to end my life or hurt others. All things said, though, I have decided to remain on Invega injections, sacrificing all the wonderful highs I used to get from dope because I’m afraid that if I stop taking Invega, I might have another psychotic break and that the BEAST inside me could drive me to commit violence on myself or others. If Invega makes me non-violent, non-sexual, docile, and stable, then I say it is a good drug."

8 / 10
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30 Report
  • DoN...
  • Taken for 1 to 6 months
  • April 27, 2022

"First off, your psychiatrist only gives this drug to you if he doesn’t like you. Threatened to sue my psychiatrist and argued with him while hospitalized before injected. After just one injection of this drug, you will no longer get morning wood, you won’t feel anything in your nether region, and you will barely get hard with erection pills. You will also gain 50+ pounds, and every woman will leave you when they realize you have the sexual function of a toddler. Your brain won’t know what “horny” feels like, you will lose all your friends, and you will be unable to laugh or cry anymore. You will just stop caring about anything anymore. This drug doesn’t care how in shape or sexual you are. It will destroy your sexual function as a male for good and turn you into a slug with no purpose. Your dick and balls will go from being a grape into a raisin. Taking this drug is basically a life sentence that ends with you dying alone while everyone tells you it’s all in your head."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.