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Comparing Acetaminophen / Oxycodone vs Tramadol

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Acetaminophen / oxycodone

Tramadol

Acetaminophen/oxycodone may be used to relieve moderate-to-severe pain that is unrelieved by nonopioid analgesics; however, its use is limited by the dependence and addiction potential of the... View more

Tramadol is a strong pain relief medicine effective for both general and nerve-related pain. Tramadol can cause dependence and use may be limited by side effects such as nausea and... View more

Prescription only

Commonly reported side effects include: pruritus, agitation, anxiety, constipation, diarrhea, hallucination, nausea, tremor, vomiting, and diaphoresis.

See the full tramadol side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	2 tablet
Dosage	325 mg-5 mg
Per Unit^*	$4.76
Cost^*	$9.51

View all acetaminophen / oxycodone prices

Quantity	6 tablet
Dosage	50 mg
Per Unit^*	$1.76
Cost^*	$10.54

View all tramadol prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Oral tablet

Oral capsule, extended release
Oral tablet
Oral tablet, extended release

Brand Names

Endocet, Nalocet, Oxycet, Percocet, Percocet 10/325, Percocet 10/650, Percocet 2.5/325, Percocet 5/325, Percocet 7.5/325, Percocet 7.5/500, Primlev, Prolate, Roxicet, Xolox View more ConZip, Qdolo, Tramadol Hydrochloride ER, Ultram

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

7.9 hours

5.2 hours

CSA Schedule**

View glossary of terms.

High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (5)

FDA Alerts (4)

Drug Interactions

A total of 589 drugs are known to interact with acetaminophen / oxycodone:

206 major drug interactions (742 brand and generic names)
372 moderate drug interactions (1615 brand and generic names)
11 minor drug interactions (48 brand and generic names)

A total of 541 drugs are known to interact with tramadol:

292 major drug interactions (1036 brand and generic names)
246 moderate drug interactions (1106 brand and generic names)
3 minor drug interactions (14 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more

Alcohol can increase the nervous system side effects of traMADol such as dizziness, drowsiness, and... View more

Disease Interactions

First Approval Date

August 31, 1976

March 03, 1995

WADA Class

View World Anti-Doping Agency classifications.

S7 - Narcotics

N/A

More Information

Consumer Resources

Advanced Reading

Advanced Reading

Professional Resources

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer