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Tizanidine and Nausea: What Users Say

Brand names: Zanaflex, Ontralfy

Nausea: mentioned by 13 users (3.4%)

Based on user experiences from 381 Tizanidine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

drowsiness 18.9%
dry mouth 9.2%
hallucinations 6.8%
dizziness 6.3%
tiredness 5.5%
vivid dreams 4.2%
headaches 3.7%
blood pressure 3.4%
nausea 3.4%
nightmares 3.4%

Reviews for Tizanidine

Commonly mentioned side effects
  • Str...
  • Taken for 1 to 6 months
  • November 11, 2019

For Muscle Spasm "I am a chronic pain patient since 1999, been on many meds. I have lower back fusion, future neck fusion, and scar tissue problems. Flexeril did nothing but make me feel sick, others just didn't work. The doctor prescribed this, and only at 4 mg 2 times a day. For me, I finally get sleep. It wouldn't be anything to go 4 days or more without any rest, now I get a few hours a night. The big issue is to be careful when getting up, as blood pressure will drop quickly. My only concern is tolerance and when it's time to stop, the withdrawal. I hope this review helps in some way."

10 / 10
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88 Report
  • Lov...
  • Taken for less than 1 month
  • January 26, 2017

For Muscle Spasm "I have MS and the associated chronic pain. My trapezius and entire neck and back are constantly in spasm mode. I do not sleep, more of a float above sleep. My nephrologist thought this would help my torso muscle spasms, several types of headaches, and facial muscle spasms plus help me sleep. No on all of the above. No sleep. No relief. A new headache was created by this, and it is causing constipation, dizziness, facial flushing, nausea, depression, and tummy pain. I took one 4 mg tablet and will not give it another chance. I am miserable enough, I do not need to add to my issues with this drug."

1 / 10
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40 Report
  • Sno...
  • Taken for 1 to 6 months
  • May 21, 2015

For Muscle Spasm "While the effects of the back were helpful, the toll it took on my liver was not good. I have many separate symptoms: nausea, pale stool, right upper quadrant pain, elevated LFT, feeling tired, and sweating."

6 / 10
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47 Report

Frequently asked questions

  • Jan...
  • January 24, 2017

For Muscle Spasm "My first muscle relaxer was Valium, which worked well, but after NY got crazy about controlled substances, I went to Flexeril, which did nothing. Then to Tizanidine. The first time I took it, I thought someone had given me LSD. I was tripping. It was wild and weird. I stopped taking it. One day, I was having the worst muscle spasms and took it again. This time, I just fell asleep. I had been on sleep meds, but nothing worked like Tizanidine. I stopped taking sleep meds and now just use Tizanidine for sleeping. I take one and a half 4 mg tablets (6 mg a night). If I'm having a bad night and have to take it more than once, I feel dizzy and nauseous the next day. The problem is that I can't take it during the day."

7 / 10
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27 Report
  • gir...
  • Taken for less than 1 month
  • April 10, 2018

For Muscle Spasm "Very first dose last night. It caused severe dizziness, dry mouth, my heart was racing. I couldn't sit up without fainting. Spent several hours on the bathroom floor since I also felt nauseous. This med is not for me."

1 / 10
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15 Report

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  • Lau...
  • Taken for less than 1 month
  • May 10, 2017

For Muscle Spasm "I have had chronic pain and muscle soreness and tightness for about 13 years. Recently, my pain management doctor left his practice, but I had 2 refills on my Tizanidine and could no longer get my Hydro :( so I got Tiz refilled. (Previously, I had only taken the Tiz at night once in a while.) The first time I took it was Sunday during the day, and it was fine, it just made me feel a bit relaxed. I also took one Sunday night before bed and slept like a rock. But it seems that this med really adversely affects me the next day. On Monday at work, I suddenly started feeling extremely tired and out of it around noon. (I didn't even take it on Monday.) Then Monday evening, I began to get very nauseous and sweaty. Very strange drug. I also got headaches from it."

2 / 10
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18 Report
  • Ker...
  • Taken for 5 to 10 years
  • April 11, 2023

"I have taken this for many years and didn’t help spasticity. It did help me fall asleep for two hours. Occasionally, I’d feel like I was having a seizure or would collapse. After several months off and just restarting again, I have a dry mouth, nausea, vomiting, chills, sweating, and 2 times I have collapsed."

5 / 10
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3 Report
  • Hur...
  • Taken for less than 1 month
  • January 10, 2022

Tizanidine for Muscle Spasm "It helped me sleep, but it made me dizzy and my thinking was off. It also made me nauseated. I was hurting so bad I actually took it four times in about 48 hours, even with the nausea. I was still feeling really off 36 hours after the last dose and would not have trusted my judgment at work. My brain not feeling right was much more concerning to me than the nausea. I have taken Flexeril in the past, but I have never felt like this."

2 / 10
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4 Report
  • 703...
  • Taken for 1 to 6 months
  • February 4, 2023

For Cluster Headaches "I'm 17, female. I was prescribed the lowest dose for my headaches and migraines. It helped a lot with those but caused severe nausea and a weight loss of 25 lbs. My doctors didn't take me off it until after 4 months."

3 / 10
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5 Report
  • All...
  • Taken for less than 1 month
  • May 11, 2013

For Muscle Spasm "This medicine is working okay on a daily basis for my symptoms. Does not cause nausea or extreme dizziness, but will make you sleepy."

8 / 10
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32 Report
  • Mos...
  • Taken for 1 to 6 months
  • July 11, 2022

For Muscle Spasm "I was given tizanidine for neuropathy, it takes effect 1 to 2 hours after the dose and is effective 3 hours after the dose. Does nothing except mild nausea and a dull headache."

1 / 10
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6 Report
  • CAN...
  • July 30, 2021

For Cluster Headaches "I'm getting headaches and nausea."

1 / 10
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7 Report
  • Tiz...
  • Taken for 10 years or more
  • October 22, 2024

"Great medication for relaxing muscles and helps with nausea by relaxing your stomach."

10 / 10
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1 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.