Lurasidone and Nausea: What Users Say

• Sta...
• Taken for 1 to 6 months
• December 19, 2013

For Bipolar Disorder "I have Bipolar Disorder II, diagnosed 4 years ago. I've taken a wide variety of medicines during that time. In my experience, many medications are good for ending a manic episode, but nothing has ever helped me with the ensuing, longer-lasting depressions. 3 months ago my psych suggested Latuda, and I agreed with zero expectations of success. The result has been miraculous. Within a week of starting, all negative feelings were gone. I experience nausea when I take it, but that is a small price to pay for such a major shift in my well-being. My appetite remains normal, and I've lost 5 pounds since starting Latuda because I have motivation to exercise again. Highly recommended to anyone who is BP II and wants to break out of depression."

• The...
• Taken for 1 to 6 months
• December 30, 2019

For Bipolar Disorder "Latuda has been a game changer for me. I am a functioning, highly anxious, super bipolar human. I have taken a lot of different meds over the years including Seroquel, Lamictal, Zyprexa, and Risperdal, all of which caused extreme fatigue and minor weight gain. Since taking Latuda, the little bit of weight came off and my mood has mostly stabilized. The only downside that I have found is that if I take it on an empty stomach in the a.m. and skip breakfast, nausea and vomiting are almost guaranteed. Sometimes I'm not in the mood to eat when I wake up but meh. Take it at night I guess to avoid that. I would recommend Latuda to anyone with Bipolar disorder as it has brought me many positive changes."

• Kal...
• Taken for less than 1 month
• January 13, 2014

For Bipolar Disorder "I'm on 200mg Lamictal and 150mg Wellbutrin for bipolar II with mania controlled and depression affecting my daily life. Added 20mg of Latuda 3 weeks ago and I've seen massive improvement. I went from sitting at home on the couch all the time to going out and applying for jobs and completing many projects around the house. It does come with drowsiness, works better than my prescribed sleep medication, and some nausea but food solves that. I don't know if my dosage will be increased but I feel great now with all my other medications plus the Latuda. Overall the pros make the cons nonexistent in my eyes."

• gue...
• December 22, 2013

For Bipolar Disorder "For over a year, I experimented with many different medicines for my Bipolar Depression without success until I started Latuda 3 months ago. I started at 20 mg and am now at 80 mg and will be staying at this dosage. My depression has lifted, it has helped tremendously with my cognition (my brain fog), and I am an active participant in my own life now. As long as I take it at night with a meal or snack, I don't experience any side effects. If you take it on an empty stomach, it makes you nauseous. The maker of Latuda has a patient assistance program as well. Overall, it has been a miracle for me!"

• Sti...
• Taken for 1 to 6 months
• February 3, 2020

For Bipolar Disorder "I have been on Latuda for about 4 months now for major depression, and it has changed my life! I struggled severely with suicidal thoughts and actions as well as self-harm. Since starting Latuda, my suicidal thoughts are completely gone. I think more rationally again, I don’t feel a need to harm or dislike myself, I finally feel like I have control of my illness. The only downside is the price, but thankfully, I was able to get my insurance to help cover it. Also, Latuda is known for lots of possible side effects. For me, I get severely nauseous if I take it after not eating enough. But it is definitely worth the benefits. Latuda is truly a miracle drug!"

• Bip...
• Taken for 1 to 6 months
• December 27, 2013

For Bipolar Disorder "I have tried many medications over the years, mostly antidepressants but a few others like lamotrigine & Seroquel. I must say that nothing has been more effective than Latuda. I was on Wellbutrin for a couple years, was ok. This does make me drowsy so I take it at night. I do have to take with food or will make me really nauseous. Truly a miracle drug as I was not doing well."

• tha...
• Taken for 1 to 6 months
• December 27, 2013

For Bipolar Disorder "I have been on all sorts of meds. Wellbutrin was beautiful but my throat swelled up and I broke out in hives. They have tried lithium (scary rashes that took 4 months to clear) some other ones that made me worse or rashes. Latuda is the first that has been close to the awesomeness of Wellbutrin. I have more energy, eat less, fog like state of not fully 'being there' is gone. I feel like a different person. The first week was nauseating but that went away and lasted a half hour at a time. When I bumped up to 40mg the nausea came back. My kidneys seem to be hurting but I am going with a wait and see if that goes away as well. I do not want to be taken off. Meds are hard to find that work."

• liv...
• August 30, 2015

For Bipolar Disorder "After 6 years of different meds that never worked, I was put on 20mg of Latuda. Didn't do anything, didn't work at all. Doc upped it to 40mg. Taking 40mg gave me maybe 3 weeks of terrible headaches and nausea. Then one morning, I woke up and actually felt good, well-rested, clear-headed...it was such a strange feeling to me. Then I turned on some music and I actually felt music again, I started dancing around while getting ready. Started reaching out socially, started exercising, and started actually taking a shower every morning again! I cannot express in words how good and normal I feel, I actually feel things again. Latuda did a 180-degree change in my life, thanks to the researchers who created this drug, you guys are amazing!"

• Ano...
• October 12, 2014

For Bipolar Disorder "It's been a love-hate relationship with Latuda for me. After 2 months of using it, I noticed a significant change in my depression, which was fantastic. But, I experience SEVERE nausea even when I eat enough food. I have even thrown up about 6 or 7 times within my 7 months of taking it. Which is unpleasant to say the least. The nausea usually sets in about 30-45 minutes after taking and lasts anywhere from 5 minutes to an hour."

• jhu...
• Taken for 1 to 6 months
• June 30, 2014

For Bipolar Disorder "Amazing medicine! My doctor finally took me off Seroquel and put me on an upped dose of Latuda, making my dosage 160 mg instead of 80 mg. I feel great and never better. I've lost 20 lbs in a month! Now I'm stuck at this weight, but I did lose most of the weight I gained before. It definitely makes me sleepy, but I've heard this goes away soon as your body adjusts. As for the nausea, I've found eating a small amount before and a larger portion after taking the medicine, and following it with a ginger pill and milk helps to stop it."

• Bip...
• Taken for 1 to 2 years
• February 25, 2016

For Bipolar Disorder "Currently taking 80mg once a day for bipolar II. Take with food at night, otherwise feel nauseous. Used to be terrified of going out in public (grocery store), and now I no longer feel anxious going shopping by myself. Had extreme road rage, everyone around me made me angry. I have no road rage at all now, even with LA traffic. I can go dancing with my friends and be completely sober, when before I'd have to have a few drinks before I'd even think about stepping out on the dance floor. Latuda has really changed my life. I am more social, less irritable, and just a better person to be around."

• Wia...
• November 24, 2014

For Bipolar Disorder "I'm diagnosed with bipolar 1 disorder with psychotic features. When I first started this medication about 8 months ago, I would get extremely tired soon after I took it, also nauseous. I have to take it at night. The tiredness put me in a low mood but not depressed. After steadily taking it, my doctor put me on a stimulant and that cancels out the tiredness. Honestly I'm so happy at this point in time and I've come so far. I have a job now and a 4.5 GPA and I volunteer. It really has changed my life. I also lost almost 40 pounds and I feel healthier and love life. If you take this medicine every day and stick to it, it really works. If I skip, I definitely feel very agitated and paranoid and angry. I take 40mg a night, sometimes I do still get nauseous."

• Ind...
• November 23, 2013

For Bipolar Disorder "I have been taking Latuda 40mg for a month now. I take it with meals as prescribed, but I still feel nauseated. I also take Vistaril, which helps with my stomach. I'm bipolar, severely anxious, along with manic depression, and I found that out of ALL the meds I've tried over the past 15 years, the combination I'm taking (Vistaril 25mg, Latuda 40mg, Neurontin 300 mg 3 x a day) and Topamax 200mg at night have balanced me out very well. I still have my normal social anxieties, and that's something I have to face, not a pill. If you are crying out of control, having major mood swings, feeling tired, or depressed, then Latuda will help you. If you feel sick to your stomach, make sure you eat first, then take it. I don't eat much, so that's why mine gets upset."

• owl...
• Taken for 1 to 6 months
• April 23, 2014

For Bipolar Disorder "I was on Latuda (started at 40mg and ended at 80mg) for about a month and a half before deciding to switch. The best thing about Latuda was the significant decrease in my appetite, but that could have been an effect of removing Seroquel from my regimen. When I first started, I had a very hard time sleeping due to restlessness, but that went away with time. The main issues I had with Latuda were a feeling of 'numbness' to the world around me (no desire to do anything or say anything), a definite decrease in my sex drive, and the cost. Neither of my insurance plans will cover it, so unfortunately, it's no longer an option. If you do decide to try it, take it with plenty of food, otherwise you may get nausea."

• Ric...
• January 28, 2015

For Bipolar Disorder "Have been on Latuda (80 mg) for 3 months and it has done wonders for me. I am primarily manic and Latuda has helped me greatly. Much better than Seroquel and a whole bunch of others. Some mild nausea but if I take it with the 350 calories required this equates to no nausea. Still suffer from elevated anxiety but that's another issue."

• Lyd...
• Taken for less than 1 month
• April 22, 2015

For Bipolar Disorder "I switched from Seroquel to Latuda 5 days ago. INSTANT IMPROVEMENT! My sweet cravings are gone, I can exercise again, and I don't feel like a slug at work. I have only one complaint: the nausea is pretty bad, I've almost thrown up a couple of times, but right now, the pros outweigh the cons. Hopefully, the nausea will subside after a while. I'll update in a month."

• Amy...
• Taken for less than 1 month
• June 4, 2020

For Bipolar Disorder "I might have bipolar, but I have definitely got bad depression that goes very low and very dark. I have been on everything and I get a little relief with a small dose of Wellbutrin 100 mg, but anymore and I cry. I started taking Latuda, and for the first three days, it was great! I felt nauseous for two days, but day three was awesome! Then I realized I was not sleeping, so my doctor added trazodone. Even with the trazodone, I could not sleep during the night; plus, the trazodone made me a zombie during the day! I quit the trazodone and changed the times of the Latuda to day and still couldn’t sleep! Last night I didn’t take anything, and I finally slept. Today I’ve felt nauseous all day! My doctor sent me a message: “You have a history of depression; let’s just stay on it and see.” Not sure what to do? I’m also hypothyroid, have got fibromyalgia, and PTSD from the army. I just don’t know what to do?"

• Mus...
• September 10, 2015

For Bipolar Disorder "Because Abilify went to generic recently, my therapist could no longer give me samples, so I had to discontinue it. After going a month with only taking my Wellbutrin and Xanax to help treat my bipolar disorder, I crashed! My therapist suggested I try Latuda, but because I have serious side effects from most drugs, I was hesitant! Finally decided, after reading a lot of reviews on here, to at least try it. I started on 20 mg and after 10 days, the only thing happening was a lot of vivid dreaming! I was still anxious and very depressed, so I increased my dosage to 40 mg and after 3 days, the depression and anxiety lifted! No nausea or weight gain, but very sleepy after a couple of hours of taking and still lots of crazy dreams! I'm happy again!"

• Los...
• May 17, 2016

For Bipolar Disorder "The therapist thinks I have bipolar II. I was taking Cymbalta, trazodone, and Klonopin. I am now only on 40 mg of Latuda and Klonopin. I feel like a zombie. I have no desire to speak when I'm with friends. I've found myself drooling sometimes, letting a small amount of drool drip out. Very embarrassing. I often find myself staring out into nothing. I have trouble keeping still most days. I have to take it with food, or I will become very nauseous. Also, I must take it before bed because it makes me drowsy. I don't like this medication. I used to be more full of life, even if I was depressed under the surface. Now I'm just a bump on a log with nothing to say. Makes me sad about this."

• Anonymous
• Taken for 1 to 6 months
• June 19, 2012

For Schizoaffective Disorder "This medicine is a godsend. I am not overly hungry on it, in fact, I have started losing weight. I have only had a little nausea, but it just seems like my stomach is weaker (i.e., I get more car sick, or more queasy when hungry). I fall asleep 2 hours after taking this, so it helps me sleep, but I don't have to pass out right away. Barely any akathisia, hardly any agitation, happiness, and energy. I have started reading, working out, and eating healthy again. I'm going back to school. It doesn't dull my senses or cognition, so I'm still intelligent and aware. I'm on 40 mg right now, and it's enough to hold back the voices and paranoia. The only frustrating thing about it is that you have to take it with 350 calories, or it absorbs less."

• Jil...
• Taken for 1 to 6 months
• February 12, 2022

For Schizophrenia "Taken for three months. Only slightly stopped paranoid thoughts. Within weeks caused severe akathisia 'restlessness or need to move,' which really means having to move 24/7 while knees and feet hurt, terror anxiety, inability for any stimulation, tremors, insane insomnia like an hour -3 a night, nausea, and diarrhea. These symptoms didn’t stop until months after stopping the med. Insomnia and outside and inside tremors after the meds took over a year. When I go to an online support group for those with akathisia who took Latuda, they all have the same issues. I’ve heard multiple times from doctors that this drug doesn’t work for schizophrenia. I often wonder where these positive reviews come from."

• sav...
• October 18, 2015

For Bipolar Disorder "I have been suffering with depression, anxiety, and suicidal thinking since age 13. I'm now 27 and have been on many different meds. Nothing has ever worked for me until I got prescribed Latuda. There are a few side effects like nausea and headaches, but that's nothing compared to how I felt before. I take 40 mg daily and recommend it to anyone who is bipolar or depressed. It REALLY works for me. I can actually live a happy and fulfilling life now. Good luck to all of you. Stay happy :-)"

• Rea...
• Taken for 6 months to 1 year
• January 2, 2013

For Schizoaffective Disorder "Great medicine! I have tried Risperdal, Seroquel, Zyprexa, Trazodone, and more... and landing on Latuda was a blessing. Between it in the evening and Lamictal in the morning, I am right as rain. Only complaint is the nausea - but this can be avoided by drinking strong lemon water with the 350 calories you must consume along with your dose. And avoid any foods, herbs, or teas that interact with the CYP3A4 liver enzyme to stay liver and heart healthy. That's it!"

• lon...
• Taken for less than 1 month
• May 25, 2015

For Bipolar Disorder "I've been taking 10 mg of Latuda for two days now. I take it in the morning with breakfast, so I haven't experienced nausea. However, I do have more difficulty getting up in the morning, but once I'm up, I seem to be more energetic than I have been in ages. Last night, I was watching a comedy show on television and laughed so hard for so long it actually scared me. Like it was completely foreign to me to express that level of happiness/giddiness. On the flip side, I've noticed that I've gained 4 pounds in two days, so that is totally freaking me out. I have always been a little overweight, so the idea of gaining more weight is untenable for me. I will be watching my weight over the next few days and see how it goes."

• Gra...
• October 31, 2015

For Bipolar Disorder "The first time I took Latuda was in the hospital, and I was put on 40 mg. I had a little nausea, but no other side effects. Later, my psychiatrist raised the dose to 80 mg. That's when I started having severe akathisia and vomiting (no weight gain or loss, though). It seemed almost intolerable, but I stuck with it for several months. I then switched to Abilify but soon was taken off antipsychotics altogether. I was stable for several months, but then started having mania again. Recently, my psychiatrist recommended that I try Latuda at a smaller dose. I was skeptical, but I decided to try it. I love it! The dose is just enough to control my symptoms, and I've had no side effects. My new insurance is denying it, though, so I'm on samples."