Inclisiran User Reviews & Ratings (Page 4)

• Wil...
• Taken for 6 months to 1 year
• March 13, 2025

Inclisiran for High Cholesterol, Familial Heterozygous "The side effects listed are about right. Had some periods of dizziness too. I have had bouts of big-time fatigue, and I think that is a result of the Leqvio. The side effects are aggravating, but in general, are worth it for the results."

• Moe...
• Taken for 6 months to 1 year
• June 20, 2024

"I am about to receive my 3rd injection. After the first injection, cholesterol went down, but triglycerides went up. Upon questioning my cardiologist, I was told that happens occasionally, but it should level out by the next injection. I had to go for a new lipid panel which showed my cholesterol was up again, but not as high, and triglycerides were down somewhat. Is this like a rebound effect? I don't know. The only side effect I had was a burning sensation as the medication was going in, and some minor aching at the site of the injection. I felt fine within 20 minutes."

• Fra...
• Taken for 6 months to 1 year
• January 28, 2025

Inclisiran for High Cholesterol "I am 76 years old and female and eat a heart-healthy diet. I am scheduled for a 3rd injection in March. To begin with, my cholesterol levels were not much over the suggested limits, but since I have hereditary high blood pressure and a family history of heart attacks, Leqvio was prescribed. I didn't want to take another prescription pill since I was already taking 5 (3 for high blood pressure, 1 for thyroid, and 1 for acid reflux). I preferred an injection 2 times a year. It is given in the fat of the arm, not the muscle, so uncomfortable side effects were minimal and brief. The only other possible side effect was cramping from my calf to my foot, mostly at night. This subsided after about a month. My bad cholesterol dropped significantly, and my good cholesterol remained very good. Although it does mean another trip to the doctor's office for the nurse to give the injection, it is very quick."

• Jul...
• Taken for 1 to 6 months
• January 29, 2025

For High Cholesterol, Familial Heterozygous "I was told it had not thrown up any side effects, but in actual fact, there are many documented. I've had a lot of musculoskeletal problems, aches, pain, unable to function well in the day, confusion, sleeping like a log, can't get up in the morning. I'm going to have one more injection. If the same happens again, I'm stopping it."

• LWD...
• Taken for 2 to 5 years
• January 5, 2025

Inclisiran "Has lower overall count to < 110 and ratio is in range first time in life, received my 7th injection on November 24, but 3 days later dry skin patches popping out on my nose and around my mouth, on the sides of my head, back, and legs. Firmly believe Leqvio is the reason. Believe cholesterol is too low in my body and is having a negative impact on my immune system."

• drc...
• Taken for less than 1 month
• May 7, 2025

Inclisiran for High Cholesterol "Started first injection 2 weeks ago. A week later, very loose bowels for three days. I don't have any muscle and joint pain like the statin drugs caused. But I am very fatigued during the day, my legs are weak. Even after sleeping 8 hours. But if it lowers my LDL and I don't have to have bypass surgery again, I can live with it. I plan on starting strength training with weights to see if I can counteract the fatigue, plus B12 supplement."

• Mix...
• Taken for 1 to 6 months
• August 8, 2025

"I have high congenital LP(a) and a genetic intolerance to statins. Repatha was effective, but caused severe back pain. Took a one-year medication break and tried to self-regulate cholesterol, but it didn’t work. Shortly after receiving the first dose of Leqvio – experienced right leg pain and lower back joint pain. Felt like a clicking motion w/sciatica and didn’t resolve for two months. About 3 weeks after the first dose, major hair loss began. Now coming out in patches. Also experiencing extreme eye dryness, and the eye doctor says formally successful treatments for Sjogren’s are no longer working. Seeing some increased skin hyperpigmentation and excessively dry skin. Do not have the overall joint muscle pain I had with statins and Repatha. Have not yet tested the cholesterol-lowering effect. Some increase in migraines. I really want this medicine to work, so I’m seeing multiple doctors next week to discuss the side effects. If they continue, may have to stop before dose #2."

• Ano...
• August 8, 2025

For High Cholesterol "Horrendous problems after the second injection. Information in pelvis and legs, the left leg hardly able to move. Pain in the muscles, unable to even put my socks on! Muscles hard and sore, pain in the groin. Severely impacted my normally very active life."

• Ano...
• Taken for 5 to 10 years
• July 13, 2025

"I have been on the study for about five years, having an injection every six months. I have not felt any discomfort apart from the last year when I have been diagnosed with diverticulitis and random itching, mainly on the torso. I do not know if I am on the placebo, but will ask at the end of the program."

• Leq...
• Taken for 1 to 6 months
• February 20, 2025

Inclisiran for High Cholesterol "Nothing seemed to work to lower my cholesterol to acceptable levels, but using Leqvio along with a statin and ezetimibe brought my total cholesterol to 126. I have had no side effects from Leqvio. My only criticism is the cost."

• 64y...
• Taken for 1 to 6 months
• August 23, 2025

For High Cholesterol "I have found inclisiran to be extremely debilitating. Blood pressure became very unstable. The pain in my pelvis and legs is very difficult to conduct a normal life with! I took this drug as I had a dreadful reaction to statins. I am now three months into my second dose and have a constant kidney infection. Terrible lymphatic problems in my legs. Deeply regretting having taken it; even though it lowered my cholesterol. It is all about quality of life! Mine has been very adversely affected by this drug. I certainly will not be taking it again."

• Div...
• Taken for 1 to 6 months
• March 15, 2023

Inclisiran for High Cholesterol "I am having the most severe muscle pain and tight muscles I have ever had since I have been on Leqvio. Has anyone else had this?"

• Anonymous
• Taken for 1 to 6 months
• May 8, 2023

Inclisiran for High Cholesterol "Side effects, hives, itching, pain with urination, headaches, dizziness, blurred vision, and sweating."

• Sus...
• Taken for 1 to 6 months
• May 25, 2023

Inclisiran for High Cholesterol, Familial Heterozygous "Have had significant hair loss. Pain in legs and knee joints. Both knees have cartilage and meniscus damage, with no previous history of knee injury or knee-related issues."

• Eli...
• Taken for 6 months to 1 year
• April 3, 2024

Inclisiran for High Cholesterol "About a month after Leqvio shot, I get heartburn, nausea, belly cramps, fatigue. Numbers are good, but not liking the side effects. Anyone else having similar issues?"

• San...
• September 4, 2024

Inclisiran for High Cholesterol "Two weeks after the first injection, I developed pain in my hips, lower back, ankles, feet, hands, including toes and fingers, burning with urination, burning in my eyes, fatigue, and headaches."

• rog...
• Taken for 6 months to 1 year
• May 19, 2024

Inclisiran for High Cholesterol "Not sure if this is related to Leqvio or not, however, since beginning the Leqvio regimen I have experienced an increased level of muscle and joint pain and reduced mobility."

• Dav...
• Taken for 1 to 6 months
• August 6, 2023

Inclisiran for High Cholesterol "Leqvio works very well to lower the LDL cholesterol, but I am having substantial weakness in my legs. No other side effects. Would hope there is some way to eliminate the weakness."

• Eli...
• Taken for 1 to 2 years
• May 22, 2024

Inclisiran for High Cholesterol "Had high hopes, but too many gastrointestinal side effects. Also muscle pain and stiffness. Lowers cholesterol but 2 months after the shot, I still have side effects."

• Mlh...
• Taken for 1 to 6 months
• March 12, 2023

Inclisiran for High Cholesterol, Familial Heterozygous "I had a terrible reaction to Repatha, so I requested Leqvio. I had my first dose 3 months ago, and I haven't had any problems with it at all. I have my second dose scheduled in another 2 weeks."

• L h...
• Taken for 6 months to 1 year
• May 28, 2024

Inclisiran for High Cholesterol "It has lowered my LDL. However, I have noticed that my skin started to wrinkle a great deal after my third shot. Has anyone else experienced this symptom? It is my only adverse reaction."

• Ano...
• Taken for 6 months to 1 year
• June 5, 2025

Inclisiran for High Cholesterol "My cholesterol is better, but I hurt all over! I don’t know if Leqvio is causing this, but I feel like I didn’t hurt this bad before!"

• Anonymous
• Taken for 6 months to 1 year
• May 6, 2023

Inclisiran for High Cholesterol "Took first dose in October 2022. Bad cholesterol was 105. Second dose in January. Bad cholesterol was 45 in February. Cardiologist was amazed!! Feel much better this summer."

• Mor...
• Taken for 1 to 6 months
• October 9, 2024

For High Cholesterol "Hair loss second month. I have fine hair, can’t afford to lose anymore."

• Anonymous
• Taken for 1 to 6 months
• January 13, 2025

Inclisiran for High Cholesterol "After my first injection, all seemed fine, but two weeks in I have arthralgias of the fingers and severe constipation, dry lips."