Inclisiran User Reviews & Ratings (Page 2)

• Bon...
• Taken for 6 months to 1 year
• January 4, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "It has tremendously lowered my LDL. Side effects known: bad joint pain in my hips and knees. Lethargy, lack of energy. Possible side effects, but need to discuss with my doctor: racing heart waking me up from a sound sleep."

• Ski...
• Taken for less than 1 month
• March 15, 2023

For High Cholesterol "No problems at the injection site. After two weeks, had pain in my extremities, both muscles and joints. After one week, pain went away. Three weeks after, I developed difficulty sleeping, unusual feelings in my head, and foggy thinking. I also have diarrhea, lethargy, and a reduced ability to exercise due to the inability to breathe. This was followed by negative thoughts and depression, which I have never experienced before. I would give $3,000.00 if I could get rid of the side effects. I have an appointment with a doctor two days from now."

• Nai...
• Taken for 1 to 6 months
• June 7, 2023

For High Cholesterol, Familial Heterozygous "I am experiencing severe muscle and joint pain, nausea, headache, sweating, palmar erythema, hives, the soles of my feet are burning hot, painful urination, and abdominal pain! Inclisiran damaged my liver! Are the side effects ever gonna go away? I was stupid to agree to have this poison. I'm really scared."

• Bil...
• Taken for 6 months to 1 year
• July 23, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "I had Repatha shots. I had some side effects similar to an allergic reaction. Eventually, I tried Leqvio. I've had 3 shots. I had severe leg pain that lasted a couple of weeks. I could not straighten my legs. My hamstrings were killing me (I'm no wimp, I know pain, I'm a retired Marine). I also have continued pain in both of my feet (never before). One weird side effect is my right nipple is constantly hard and painful. That started with the Repatha but went away when I stopped. Now it's back. I actually saw a specialist who prescribed me a hormone treatment. I'm not taking another drug to deal with a side effect from another. The good news is it has reduced my number from 250 to 201."

• Joh...
• Taken for 1 to 6 months
• May 6, 2023

Inclisiran for High Cholesterol, Familial Heterozygous "I am a 74-year-old male. Just had the second dose of Leqvio. (I had to stop Praluent after two dosages due to extreme itching.) LDL has reduced by 50% after the first dosage 3 months ago. I have experienced slight muscle discomfort, but nothing major. Highly recommend treatment, but it is expensive."

• Gay...
• Taken for less than 1 month
• October 26, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "Leqvio brought my cholesterol down by 199 points, however, the arm that was injected is seriously injured. I hope it’s temporary, but it’s hard to even use the arm at this point, and it’s my dominant arm."

• pea...
• Taken for 1 to 6 months
• November 13, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "Equivalent to Repatha for cholesterol reduction (I've been on Repatha for over 10 years). I'm in the first 3 months phase. No side effects except one: I was on an ultra-low fat diet for 2 weeks, and in the second week I had memory loss similar to statins (could not 'reach' for words or phrases, could not remember locations of items after 3 minutes). After adding a modest amount of fat back in my diet, the memory problems cleared up rapidly."

• Gti...
• Taken for less than 1 month
• October 3, 2024

Inclisiran for High Cholesterol "Had first injection 9/19/24 with just a slight burning sensation. Monday 9/30/24 mild muscle aches and spasms in arms, shoulders, legs, and lower back. Thursday 10/3/24 moderate muscle aches daily with difficulty sleeping. I eat a healthy diet and work out several times weekly. Hopefully, the side effects will subside, and I can continue my workouts without pain and discomfort. Since I just started the program, I will stick with it until the second injection. Am not sure if I will complete the program."

• Har...
• Taken for 1 to 6 months
• June 4, 2024

Inclisiran for High Cholesterol "Had starter dose end of October. Had regular injection Jan. 31. Began having leg spasms, some cramping. It's June and symptoms have not abated. How long should any side effect last? LDL-C went from 122 to 55 after the second dose."

• Its...
• Taken for 2 to 5 years
• October 14, 2023

Inclisiran for High Cholesterol, Familial Heterozygous "I am on 5th Jap, and this wonder drug brings down my bad cholesterol from 181 to 92, below 100, the recommended figure to be safe from a heart attack. My good cholesterol shot up to 60, but not sure it’s because of Leqvio or my food habit. I got zero side effects, nothing, but when I took Repatha, I felt like dying, so do other statins."

• Mik...
• Taken for 1 to 2 years
• August 11, 2024

Inclisiran for High Cholesterol "I'm a 77-year-old man in good health. I just had my third 6-month injection from Metro Infusion Center. I'm happy to report no lasting side effects after my last injection. Site injection pain disappeared in less than 24 hrs. So far, I'm very happy with it. All my extensive blood work results come back normal, including my blood glucose level (85)."

• Dav...
• Taken for 1 to 6 months
• November 2, 2024

Inclisiran "Have just started this, one dose over 3 months, just taken 2nd dose. Have not seen any positive test results yet. My wife also started Leqvio at the same time as I did. She also is Type One for over 60 years. She did not take the 2nd round of injections. Her triglycerides had been normal, after the test, before the 2nd round of meds, they were over 1000. We have had her at doctors, all kinds of heart tests. Did not work for her, may not work for me unless test results in the next two months indicate a positive outcome. As with all diabetics, lowering all 'bad' blood test results is critical, hopefully, this could work, but not for all."

• Jay...
• Taken for 1 to 6 months
• September 5, 2024

Inclisiran for High Cholesterol "Painful joints when moving around after sitting. Troublesome cough. Feeling nauseous frequently, especially in the morning before breakfast. Night cramps every night disturbing sleep, and therefore causing tiredness the next day. Extreme fatigue during the day needing an afternoon nap."

• Drs...
• Taken for 1 to 2 years
• July 21, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "I took statins for 38 years. While they may have lowered my cholesterol, they did not mitigate my eventual need for CABG surgery. I took the Repatha shots for 2 1/2 years and didn't have too many negative side effects, but didn't like the need for injections every 14 days and began noticing that I would get purpura. My cholesterol level remained at good levels. Changing to Leqvio was beneficial because there is only a need for 2 injections annually, however, my cholesterol readings are somewhat higher and the purpura has increased. I fear that I am beginning to gain a little weight from Leqvio since there have been no changes in my diet or exercise routines. I am very bothered by the frequency and size of the purpura."

• Nic...
• Taken for 1 to 2 years
• March 30, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "Works awesome! Knocked the LDL down to almost in range. Had to additionally take Nexletol to nail the range because I cannot take a statin... Was extremely hard to have the insurance approve both drugs."

• Lin...
• Taken for 1 to 6 months
• August 25, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "First off, I do have fibromyalgia and Sjögren’s, but after the first shot, the pain definitely went up, and I had chronic bronchial congestion. After the second shot two months ago, the pain accelerated in my knees, feet, legs, sides, chest, shoulders, and wrists. And I still have lots of congestion. I attributed the severe pain to the injection which, of course, as many say, did really help my cholesterol numbers greatly, but my next shot is in December, and I think I may not bother with it as the pain and anxiety that I attribute to the shot are not worth it. Reading these reviews and other reviews of this drug, it sounds like it just causes incredible mental muscle stiffness and congestion for many people. It works well for what it was designed to do: lowering all the numbers, and I appreciate that, but this is tough being in pain."

• you...
• Taken for 1 to 2 years
• October 2, 2024

Inclisiran for High Cholesterol "No problems with the injection site, only sore for about an hour, then nothing. As for the side effects, I seem to get a cold 3-7 days after the injection. Once very severe, with coughing, but my last injection only produced a runny nose and some upper chest congestion. I have BPH, so it is hard for me to determine if some burning and slight pain is caused by the BPH or the injection. As for my LDL, it has been reduced by about 30%."

• Wil...
• Taken for 6 months to 1 year
• December 20, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "The drop in my total cholesterol number was dramatic the first 90 days. Dropped from about 280 to 155. My LDL dropped from something like 90 to 55. Won't have the second blood work until two months from now. Side effects: The most aggravating side effect was not diarrhea, but overly soft stools. The overly soft stools cause big-time hygiene problems. This side effect started about two weeks after the shot and continued for about a month. After the second shot, the very soft stools began around two weeks following the shot and continued off and on for a few months. Very, very aggravating. I may have had at times a slight increase in having to urinate. Barely noticeable, but it did happen, and I can't say exactly when that began or tapered off. Haven't had (so far) any undue muscle aches or stiffness."

• Jay...
• Taken for 1 to 6 months
• April 13, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "I've just had my second injection. Cholesterol dropped, so that's a positive. I still have an injection site rash, possibly due to this last injection being very uncomfortable, unlike the first one. My IBS has been really bad this time too, but not sure if connected. Jury's still out as to whether I would have a 3rd."

• Joo...
• Taken for 1 to 6 months
• February 28, 2025

For High Cholesterol "Had first injection of inclisiran September 2024. Twelve hours later, suffered stomach cramps, had to sit on the toilet for two hours! Felt bloated and sick, could not eat, loose stools. This lasted five weeks. Digestive system has not been right since. Have craved sugary foods. Now have joint pain in knees, hands, and feet. Severe pain that left me doubled up, now diagnosed with gallstones. It did lower LDL by half, but the side effects are too much. Still not right and coming up to six months after injection. Consultant kept telling me there are no side effects! Glad I am not making it up as has been implied. There has to be quality to life, not just quantity."

• JMJ...
• Taken for 1 to 6 months
• June 20, 2023

For High Cholesterol "I had my first injection in the 1st week of April. On the second week of May, my right foot was slightly swollen, and my joints in my toes were very stiff. Unfortunately, I tripped on something quite small while cleaning out my garage. I did not fall, but I fractured my third toe. It is finally healed after 5 weeks, mostly wearing a brace-like shoe. I am now resuming normal walking. However, at the beginning of the second week in June, I lost my balance and simultaneously noticed how stiff my right arm and hand were, so much so that I couldn't effectively break my fall. I fractured my wrist from that experience. I will be in a brace-like mechanism for four weeks. I am due in 4 weeks for another injection. Not at all sure I will continue the treatment."

• Pau...
• Taken for 1 to 6 months
• August 5, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "I am a medical professional. I am 78 y/o. Past history of CABG X3 at age 40 in 1987, total cholesterol of 385 and high LDL and low HDL. All numbers are now substantially lowered. Chol now 165. LDL-C is 76, was 165. I haven't noticed any new problems as far as side effects after my first two injections. I have a previous history that includes sciatic distribution pain and discomfort due to mild scoliosis, cervical and lumbar spinal stenosis, and disc problems. Chronic pain controlled presently with Naprosyn and Tylenol ES. Have had no injection site problems or any other obvious new onset problems. I am 78 years old and pretty active. As with every statin I've ever taken, I always wonder whether I am having age-related loss of libido and ED vs. side effects due to medication. I cannot differentiate any new musculoskeletal pain or discomfort with current pain present long before the first Leqvio injection. I have had the first two prelim shots with the next one due in 6 months."

• pau...
• Taken for 6 months to 1 year
• June 20, 2024

Inclisiran for High Cholesterol "Two shots so far. Both times, worse stiff toes and ankles, low back pain, stiff neck, and shoulders. First time, these resolved in about a week. Stiff toes and ankles never resolve completely along with numbness in feet as a result of taking statins. Deemed statin intolerant, which is why trying the Leqvio shot. Odd side effect both times is eye irritation that feels like a stye coming on but never develops. Doing blood work to see how results are with two shots and low-fat lifestyle (down 25 lbs, weigh now what I did in my 20s). It better help or not sure all this is worth it! (Recommend with the caveat of the above)"

• Gui...
• Taken for less than 1 month
• October 19, 2024

Inclisiran for High Cholesterol "In 2022, I got my first Leqvio injection in the doctor's office. I loved the results, my HDL cholesterol went to normal for a long period of time. This is the only medicine my body tolerated without any secondary effects. I beg my doctors to please get me back on, they prescribe, but insurance declined, subject to a letter of necessity, but that fails to fulfill the purpose. The doctor's office claims they did submit insurance claims, they never got it. I still need this injection. I have conventional Medicare Part B and D."

• MJ ...
• Taken for less than 1 month
• February 6, 2025

Inclisiran for High Cholesterol "The drug does work to lower LDL, but for me, the side effects aren’t worth the risk. I experienced the following: The injection pain lasted 20 min, but very painful! Severe shoulder pain 2 days after injection, lasted 2 days. Some joint pain, slight, but irritating cough ever since the first week. I had a very, very painful blood clot in my leg that lasted 2 weeks. My eyes became somewhat red, like they were bleeding. It was scary. The biggest factor for me was a big jump in my glucose fasting level. I knew this because I had blood work a week before the injection. I had blood work again 2 weeks after the shot. I’m not going to continue taking the drug. I’m eating clean, and I’ll take my chances. I don’t want to exchange one problem for numerous others."