Inclisiran and Fatigue: What Users Say

• K-T...
• Taken for 1 to 6 months
• August 15, 2024

Inclisiran for High Cholesterol "Just had 2nd injection…side effects abound (headache, nausea, muscle weakness and pain, low backache, constipation, ridiculous levels of fatigue, and much more) and never fully dissipated after 1st injection…fully started up again with this injection…all are annoying and affect quality of life…arthritis pain in hands and feet, and cramping in feet, legs, hands are among the worst along with the continual migraine. The medication definitely dramatically lowered my LDL…just not sure I want to continue."

• Ken...
• Taken for 6 months to 1 year
• May 1, 2025

Inclisiran for High Cholesterol "After taking the first shot, I developed great fatigue, which worsened after each additional shot. I was diagnosed with a heart condition by the name of bigeminy. The office that administered the shot was greatly offended that I questioned the shot possibly causing this condition. My heart doctor agreed this was the likely cause. I am 5 months past the third shot and taking no more…ever. The bigeminy is clearing up on its own, thankfully, given further evidence that it was caused by the shot. Planning on reporting it to the FDA when I find the information of where it needs to go."

• Jay...
• Taken for 1 to 6 months
• September 5, 2024

Inclisiran for High Cholesterol "Painful joints when moving around after sitting. Troublesome cough. Feeling nauseous frequently, especially in the morning before breakfast. Night cramps every night disturbing sleep, and therefore causing tiredness the next day. Extreme fatigue during the day needing an afternoon nap."

• Fra...
• Taken for 1 to 6 months
• November 8, 2024

"I was okay for the first month of the vaccine, and now fatigue, cramp, and UTI. I could not tolerate any of the statins, even in small doses, but while my good cholesterol was good, my LDL was bad! While I have had migraines in the past and cramps in my leg, it seems worse. So I am unsure if the side effect of fatigue is old age, as I have never been old before, lol. I am a 78-year-old woman who is fit and well, apart from this problem with familial cholesterol. The main pain is the price, $1,449!"

• Wil...
• Taken for 6 months to 1 year
• March 13, 2025

Inclisiran for High Cholesterol, Familial Heterozygous "The side effects listed are about right. Had some periods of dizziness too. I have had bouts of big-time fatigue, and I think that is a result of the Leqvio. The side effects are aggravating, but in general, are worth it for the results."

• drc...
• Taken for less than 1 month
• May 7, 2025

Inclisiran for High Cholesterol "Started first injection 2 weeks ago. A week later, very loose bowels for three days. I don't have any muscle and joint pain like the statin drugs caused. But I am very fatigued during the day, my legs are weak. Even after sleeping 8 hours. But if it lowers my LDL and I don't have to have bypass surgery again, I can live with it. I plan on starting strength training with weights to see if I can counteract the fatigue, plus B12 supplement."

• San...
• September 4, 2024

Inclisiran for High Cholesterol "Two weeks after the first injection, I developed pain in my hips, lower back, ankles, feet, hands, including toes and fingers, burning with urination, burning in my eyes, fatigue, and headaches."