Inclisiran and Muscle Pain: What Users Say

• Lou...
• March 9, 2023

Inclisiran for High Cholesterol, Familial Heterozygous "After 45 days of use, I have developed severe muscle pain and lower body stiffness, much worse than statin pain. I do not have brain fog, muscle cramps, skin rashes, or other problems I had with statins."

• Sue...
• Taken for 1 to 6 months
• May 17, 2023

Inclisiran for High Cholesterol, Familial Heterozygous "I have had my first and second doses of Leqvio, and unfortunately, I am having a lot of muscle and joint pain - primarily in my back, neck, and shoulders. It is quite similar to the pain I was having from taking statins, so not sure why that is. It has definitely improved my cholesterol numbers, which is a plus."

• Nai...
• Taken for 1 to 6 months
• June 7, 2023

For High Cholesterol, Familial Heterozygous "I am experiencing severe muscle and joint pain, nausea, headache, sweating, palmar erythema, hives, the soles of my feet are burning hot, painful urination, and abdominal pain! Inclisiran damaged my liver! Are the side effects ever gonna go away? I was stupid to agree to have this poison. I'm really scared."

• Gti...
• Taken for less than 1 month
• October 3, 2024

Inclisiran for High Cholesterol "Had first injection 9/19/24 with just a slight burning sensation. Monday 9/30/24 mild muscle aches and spasms in arms, shoulders, legs, and lower back. Thursday 10/3/24 moderate muscle aches daily with difficulty sleeping. I eat a healthy diet and work out several times weekly. Hopefully, the side effects will subside, and I can continue my workouts without pain and discomfort. Since I just started the program, I will stick with it until the second injection. Am not sure if I will complete the program."

• Lin...
• Taken for 1 to 6 months
• July 9, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "Started taking first shot March 2 shot June. It is, I believe, responsible for incredible muscle. Stephen is in pain especially in my back and my ribs. It did, however, lower my numbers quite a bit, so I’m grateful for that, but I am not sure it’s worth it if I’m going to be in such severe pain. I hope that the pain goes away in a few weeks when it works through my system."

• Wil...
• Taken for 6 months to 1 year
• December 20, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "The drop in my total cholesterol number was dramatic the first 90 days. Dropped from about 280 to 155. My LDL dropped from something like 90 to 55. Won't have the second blood work until two months from now. Side effects: The most aggravating side effect was not diarrhea, but overly soft stools. The overly soft stools cause big-time hygiene problems. This side effect started about two weeks after the shot and continued for about a month. After the second shot, the very soft stools began around two weeks following the shot and continued off and on for a few months. Very, very aggravating. I may have had at times a slight increase in having to urinate. Barely noticeable, but it did happen, and I can't say exactly when that began or tapered off. Haven't had (so far) any undue muscle aches or stiffness."

• Sou...
• Taken for less than 1 month
• June 4, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "This is in regards to side effects of Leqvio. Had the first injection about five days ago. No pain or redness at the injection site. A bit of soreness at the injection site for about 24 hours. A lethargic feeling off and on since the injection. A small amount of muscle or joint pain in the first 72 hours after the injection. No diarrhea as yet. Slightly loose BMs. No fever. Have experienced periods of being 'light-headed', i.e. feeling faint. Have not communicated this to my physician yet. Will do so later this week. I am hopeful this injectable medication will lower my LDL and thus, my total cholesterol number."

• Pau...
• Taken for 1 to 6 months
• August 5, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "I am a medical professional. I am 78 y/o. Past history of CABG X3 at age 40 in 1987, total cholesterol of 385 and high LDL and low HDL. All numbers are now substantially lowered. Chol now 165. LDL-C is 76, was 165. I haven't noticed any new problems as far as side effects after my first two injections. I have a previous history that includes sciatic distribution pain and discomfort due to mild scoliosis, cervical and lumbar spinal stenosis, and disc problems. Chronic pain controlled presently with Naprosyn and Tylenol ES. Have had no injection site problems or any other obvious new onset problems. I am 78 years old and pretty active. As with every statin I've ever taken, I always wonder whether I am having age-related loss of libido and ED vs. side effects due to medication. I cannot differentiate any new musculoskeletal pain or discomfort with current pain present long before the first Leqvio injection. I have had the first two prelim shots with the next one due in 6 months."

• cel...
• Taken for 1 to 2 years
• January 27, 2024

For High Cholesterol, Familial Heterozygous "I've had 3 injections, last one early December. Straight away, it floored me: headache, blurred vision, feeling weak all the time, muscle and joint pain, can't walk far, so much pain in hips, shivers, like I had influenza all the time. Quality of life-I was an energetic person. I had this injection. On a positive side, reduced cholesterol level in half. I'm due for another injection in June 24, not having it. My life has changed so much. I'll take my chances in exchange for the quality of life to return to what it was!"

• Div...
• Taken for 1 to 6 months
• March 15, 2023

Inclisiran for High Cholesterol "I am having the most severe muscle pain and tight muscles I have ever had since I have been on Leqvio. Has anyone else had this?"

• rog...
• Taken for 6 months to 1 year
• May 19, 2024

Inclisiran for High Cholesterol "Not sure if this is related to Leqvio or not, however, since beginning the Leqvio regimen I have experienced an increased level of muscle and joint pain and reduced mobility."

• Eli...
• Taken for 1 to 2 years
• May 22, 2024

Inclisiran for High Cholesterol "Had high hopes, but too many gastrointestinal side effects. Also muscle pain and stiffness. Lowers cholesterol but 2 months after the shot, I still have side effects."

• Fre...
• Taken for 2 to 5 years
• June 29, 2024

Inclisiran for High Cholesterol, Familial Heterozygous "Have just received my 4th injection. Further to my May '23 post. Cholesterol has remained low, slight muscle pain continues, believe it has contributed to some hair loss. Feel overall more energetic."