Inclisiran and Muscle Aches: What Users Say

• Lou...
• March 9, 2023

For High Cholesterol, Familial Heterozygous "After 45 days of use, I have developed severe muscle pain and lower body stiffness, much worse than statin pain. I do not have brain fog, muscle cramps, skin rashes, or other problems I had with statins."

• Joh...
• Taken for 1 to 6 months
• May 6, 2023

For High Cholesterol, Familial Heterozygous "I am a 74-year-old male. Just had the second dose of Leqvio. (I had to stop Praluent after two dosages due to extreme itching.) LDL has reduced by 50% after the first dosage 3 months ago. I have experienced slight muscle discomfort, but nothing major. Highly recommend treatment, but it is expensive."

• Sta...
• Taken for 6 months to 1 year
• March 14, 2024

For High Cholesterol, Familial Heterozygous "I could not take statins without side effects. Sore muscles, aching joints. I was crying at night, could not sleep. After using Leqvio for 2 doses, I don't even need to take any statins. I also changed the way I eat."

• Hal...
• Taken for 1 to 2 years
• July 30, 2025

For High Cholesterol "WEEK 1 1. Post-administration [SQ Abdominal Area] Pain at the injection site. 2. Moderate to severe tiredness [Lethargy] lasting 4 days. 3. Irregular heart rhythms [Atrial Tachycardia] [Sinus Tachycardia]. 4. Generalized muscle aches and pains [Specifically in Legs]. 1. Increased vertigo coupled with moderate headaches [Frontal headaches]. WEEK 2 2. Mild intractable nausea requiring OTC antiemetic drugs. 3. Painful muscle cramping [Specifically in Legs & Feet, Toes]. 4. Out of control blood glucose levels [Requiring introduction of Insulin]. WEEK 7 1. Urinary urgency [Specifically at night]. 2. Painful hands, burning sensations in tendons of digits [Fingers]. 3. Cough with constant production of thick mucus [Bronchitis]. 4. Weakness in lower extremity [Legs]. WEEK 12 1. Frequent onsets of sudden severe vertigo and leg weakness. 2. Continued out of control blood glucose levels [Requiring higher doses of Insulin]."

• Div...
• Taken for 1 to 6 months
• March 15, 2023

For High Cholesterol "I am having the most severe muscle pain and tight muscles I have ever had since I have been on Leqvio. Has anyone else had this?"