Inclisiran and Cramps: What Users Say

• K-T...
• Taken for 1 to 6 months
• August 15, 2024

Inclisiran for High Cholesterol "Just had 2nd injection…side effects abound (headache, nausea, muscle weakness and pain, low backache, constipation, ridiculous levels of fatigue, and much more) and never fully dissipated after 1st injection…fully started up again with this injection…all are annoying and affect quality of life…arthritis pain in hands and feet, and cramping in feet, legs, hands are among the worst along with the continual migraine. The medication definitely dramatically lowered my LDL…just not sure I want to continue."

• Jay...
• Taken for 1 to 6 months
• September 5, 2024

Inclisiran for High Cholesterol "Painful joints when moving around after sitting. Troublesome cough. Feeling nauseous frequently, especially in the morning before breakfast. Night cramps every night disturbing sleep, and therefore causing tiredness the next day. Extreme fatigue during the day needing an afternoon nap."

• Har...
• Taken for 1 to 6 months
• June 4, 2024

Inclisiran for High Cholesterol "Had starter dose end of October. Had regular injection Jan. 31. Began having leg spasms, some cramping. It's June and symptoms have not abated. How long should any side effect last? LDL-C went from 122 to 55 after the second dose."

• Fra...
• Taken for 1 to 6 months
• November 8, 2024

"I was okay for the first month of the vaccine, and now fatigue, cramp, and UTI. I could not tolerate any of the statins, even in small doses, but while my good cholesterol was good, my LDL was bad! While I have had migraines in the past and cramps in my leg, it seems worse. So I am unsure if the side effect of fatigue is old age, as I have never been old before, lol. I am a 78-year-old woman who is fit and well, apart from this problem with familial cholesterol. The main pain is the price, $1,449!"

• fem...
• Taken for less than 1 month
• April 19, 2025

Inclisiran for High Cholesterol, Familial Heterozygous "First of all, I see a functional dietitian. Following a strict diet, regular exercise, and taking magnesium, vitamin D, vitamin K, I was able to drop 20 lbs in a year. My starting cholesterol was 315 and with a low-fat, no seed oil, higher protein diet, I was able to get my cholesterol down to 235. My LDL-C was 170. CA score of 165. So here I am, I had my first shot of Leqvio. Side effects are exhaustion, headaches, and foot and hand cramps. Extra water and magnesium seem to help."

• Fra...
• Taken for 6 months to 1 year
• January 28, 2025

Inclisiran for High Cholesterol "I am 76 years old and female and eat a heart-healthy diet. I am scheduled for a 3rd injection in March. To begin with, my cholesterol levels were not much over the suggested limits, but since I have hereditary high blood pressure and a family history of heart attacks, Leqvio was prescribed. I didn't want to take another prescription pill since I was already taking 5 (3 for high blood pressure, 1 for thyroid, and 1 for acid reflux). I preferred an injection 2 times a year. It is given in the fat of the arm, not the muscle, so uncomfortable side effects were minimal and brief. The only other possible side effect was cramping from my calf to my foot, mostly at night. This subsided after about a month. My bad cholesterol dropped significantly, and my good cholesterol remained very good. Although it does mean another trip to the doctor's office for the nurse to give the injection, it is very quick."