Inclisiran User Reviews & Ratings

• Afraid
• Taken for 1 to 6 months
• April 22, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "Since first the injection my A1C has spiked to 12.5 and my blood glucose is dangerously high. This has necessitated the prescription of Insulin which has a range of serious side effects. While my bad cholesterol level has dropped there has been no effect on triglycerides. Good cholesterol was in the normal range prior to Leqvio and is holding. Angina chest pain and difficulty moving with overall neuralgia are other unwanted symptoms. I am due for a second injection and have reservations."

• Mike
• Taken for 1 to 2 years
• September 24, 2023

Leqvio (inclisiran) for High Cholesterol "Update to my post on August 2023. 4 weeks after my 4th injection, I was diagnosed with a sterile UTI bladder infection. On top of that, I have had multiple night leg cramps and joint and muscle pains from head to toe. I told the doctor I will not be taking any more injections and I will go back to 5mg Crestor every third day. I can't find any information about how long it takes for Leqvio to get out of the system. Hopefully, I will feel better at the 6-month mark and pray no permanent damage was done. I was so hopeful since I had no initial symptoms, but it was not meant to last."

• Linda
• Taken for 1 to 6 months
• February 9, 2024

Leqvio (inclisiran) for High Cholesterol "Had first dose. Have been experiencing leg cramps, not severe, wearing support hose helps a lot. The other thing I am experiencing is migraine headaches. Although the shot was given Dec. 14th, the headaches started the week of February 9th. Has anyone had this problem?"

• Louis...
• March 9, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "After 45 days of use I have developed severe muscle pain and lower body stiffness, much worse than statin pain . I do not have brain fog, muscle cramps , skin rashes or other problems I had with statin."

• youra...
• Taken for 6 months to 1 year
• August 17, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "The real answer is, I don't know. I'm on my 4th injection and haven't noticed side effects. But I have numerous problems with recovery from CABG surgery that could be misunderstood and attributed to this medication. I do have severe leg and calf cramps at times, and I am starting to believe it is Leqvio. In the past, my cramps became so severe I ended up rupturing an Achilles tendon, this was while taking Repatha. I stopped Repatha and the cramps stopped. But recently while taking Leqvio, I started similar cramps, and they can be severe. Now since the med is administered every 6 months, it is hard to stop it and see viable results, no cramps. Not sure what to do at this time."

• Doc
• Taken for 6 months to 1 year
• June 27, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "My cholesterol numbers have dropped specifically Lp(a) has gone down significantly. I like not having to give myself an injection every 2 weeks as I did with Repatha. I have some annoying side effects, however, including a productive cough, UTI's, problems, and sometimes painful urination, and frequently I feel dizzy which is very annoying. I believe that I am losing my hair due to this drug."

• chuck
• Taken for 1 to 6 months
• September 29, 2023

Leqvio (inclisiran) for High Cholesterol "Leqvio lowered my cholesterol to 128, but the side effects include shortness of breath, diarrhea, weight loss of 28 lbs in 6 months, chest pains, frequent urination, muscle cramps. I could barely walk and had to undergo several tests including a colonoscopy, angiogram, and lung examination. It was determined that all these symptoms were caused by the medication. Doctors have taken me off of Leqvio. It was effective, but I can't tolerate it."

• Mike
• Taken for 1 to 2 years
• August 19, 2023

Leqvio (inclisiran) for High Cholesterol "Just had my 4th shot. After my second, I had labs drawn and all my numbers dropped by about 40%. HDL, LDL, Trigl, every level is perfect according to my doctor. Very pleased. No side effects at all. So glad because I tried every statin and all caused tremendous pain, especially in joints and feet. Cost covered by Medicare and Supplement. Male age 69."

• Hate...
• Taken for less than 1 month
• April 4, 2024

Leqvio (inclisiran) for High Cholesterol "I am on week 3 following the initial dose. Week 1 had minimal side effects: cough, a little sore muscles. Week 2 full-blown Bronchitis, cough, shortness of breath, absolute misery. Week 3 Bronchitis calming down, but now have extreme tiredness. I sleep 8-10 hours and still need a mid-afternoon nap. Before the injection, I'd sleep 6-9 hours and wake up well-rested and full of energy. I hope these side effects go away soon. If not, no more injections for me - Quality of life trumps this 'cure'."

• Mlh
• Taken for 1 to 6 months
• April 23, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "I had my second dose of Leqvio 2 weeks ago. I know it's working because the xanthelasma in the corner of my eye totally disappeared. I came here to give it another great review but noticed the reviews about major muscle pain. I am in extreme pain but thought it was from my fibromyalgia. I am now wondering if it's from the leqvio?? I see my doctor soon and will be asking her. So far though this is the only thing that has been working for me. I had that reaction to Repatha and I hated statins."

• Jfox
• Taken for 1 to 6 months
• September 19, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "Don't know yet if it helped. Switched from Repatha due to cost. After the first dose, LDL was higher, but the doctor said to wait until the second dose to see. I had a bad headache, dizziness, brief shortness of breath, and exhaustion after the first dose. After the second dose, all those effects were repeated (except shortness of breath) but for a longer period, lasting over two weeks. After 6 weeks, I am still experiencing exhaustion and occasional headaches. I think I'm losing my hair and my feet itch like crazy. Is all of this related? I feel like a hypochondriac. I hope the exhaustion is not permanent. I will be going back to Repatha... I will have to find a way to pay for it."

• Sue
• Taken for 1 to 6 months
• May 17, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "I have had my first and second doses of Leqvio and unfortunately, I am having a lot of muscle and joint pain - primarily in my back, neck, and shoulders. It is quite similar to the pain I was having from taking statins so not sure why that is. It has definitely improved my cholesterol numbers which is a plus."

• Mimi
• Taken for 1 to 2 years
• October 4, 2023

Leqvio (inclisiran) for High Cholesterol "My LDL went from 124 to 54 after the first shot. I have had trouble breathing a few times, which never happened before. But I think it's causing hair loss, and I noticed several people mentioned that, but it's not listed as a side effect. The shot itself is painful for a short while. Wish I knew for sure if it was causing my hair loss."

• Mlh
• Taken for 6 months to 1 year
• July 12, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "Well, I have commented on here before about my results with Leqvio. I have had two shots now, and my side effects have been some muscle pain, and I got a condition called LPP from the Repatha which continues. This is hair loss. I don't know if the Leqvio is continuing it, but I just got my first cholesterol blood results and I am shocked! 18 months ago, my total cholesterol was 359. Today, my total cholesterol is 212, almost normal. Even my triglycerides, which it is not supposed to help, went down from 187 to 157. My cholesterol has been high all my life... over 300, so to see it this low, I am stunned!"

• Naive
• Taken for 1 to 6 months
• June 7, 2023

For High Cholesterol, Familial Heterozygous "I am experiencing severe muscle and joint pain, nausea, headache, sweating, palmar erythema, hives, the soles of my feet are burning hot, painful urinating, and abdominal pain! Inclisiran damaged my liver! Are the side effects ever gonna go away? I was stupid to agree to have this poison. I'm really scared."

• Skip
• Taken for less than 1 month
• March 15, 2023

For High Cholesterol "No problems at the injection site. After two weeks had pain in my extremities both muscles and joints. After one week pain went away. Three weeks after, I developed difficulty sleeping, unusual feelings in my head, and foggy thinking. I also have diarrhea, lethargy, and a reduced ability to exercise due to the inability to breathe. This was followed by negative thoughts and depression which I have never experienced before. I would give $3000.00 if I could get rid of the side effects. I have an appointment with a doctor two days from now."

• O R D
• Taken for 6 months to 1 year
• October 12, 2023

Leqvio (inclisiran) for High Cholesterol "Leqvio has done an amazing job at lowering LDL and total cholesterol. I have noticed muscular and joint pain, and a persistent cough since taking it. Also, shortness of breath on even very light activity levels. Other than that, it has done a great job at lowering cholesterol."

• John
• Taken for 1 to 6 months
• May 6, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "I am a 74 year old male.Just had second dose of Leqvio.(I had to stop Praluent after two dosages due to extreme itching). LDL has reduced by 50% after the first dosage 3 months ago. I have experienced slight muscle discomfort but nothing major Highly recommend treatment, but it is expensive."

• Its...
• Taken for 2 to 5 years
• October 14, 2023

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "I am on 5th Jap and this wonder drug bring down my bad cholesterol from 181 to 92 below 100 the recommended figure to be safe from heart attack…my gd cholesterol shoot upto 60 but nt sure it’s bcoz of leqvio or my fd habit…I got zero side effects…noting but when I took repatha I felt like dying so do other satins"

• Tommy
• Taken for 1 to 6 months
• February 20, 2024

Leqvio (inclisiran) for High Cholesterol "Soon after taking my first injection, I experienced fatigue lasting several days. I also started seeing blood clots in my urine. I discontinued, but periodic blood clots continue sporadically. Had a cystoscopy and CT that were negative. My gums also started bleeding immediately afterwards. I would think twice about this “new” drug without much of a track record. It did dramatically reduce my numbers, but the bleeding was very concerning."

• Bon
• Taken for 6 months to 1 year
• January 4, 2024

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "It has tremendously lowered my LDL. Side effects known: bad joint pain in my hips and knees. Lethargy, lack of energy. Possible side effects, but need to discuss with my doctor: racing heart waking me up from a sound sleep."

• JMJ
• Taken for 1 to 6 months
• June 20, 2023

For High Cholesterol "I had my first injection in 1st week of April. On second week of May my right foot was slightly swollen and my joints in toes were very stiff. Unfortunately, I tripped on something quite small cleaning out my gargage. I did not fall but I fractured my third toe. It is finally healed after 5 weeks- mostly wearing a brace like shoe. I am now resuming normal walking. However, at the beginning of the second week in June, I lost my balance and simultaneously noticed how stiff my right arm and hand were so much so that I couldn't effectively break my fall. I fractured my wrist from that experience. Will be in a brace like mechanism for four weeks. I am due in 4 weeks for another injection. Not at all sure I will continue the treatment."

• Nick
• Taken for 1 to 2 years
• March 30, 2024

Leqvio (inclisiran) for High Cholesterol, Familial Heterozygous "Works awesome! Knocked the LDL down to almost in range. Had to additionally take Nexletol to nail the range because I cannot take a statin... Was extremely hard to have the insurance approve both drugs."

• KMR
• Taken for less than 1 month
• March 3, 2024

For High Cholesterol, Familial Heterozygous "First dose in January. Injection site was painful for a good two weeks. Glad it was in my thigh. Two weeks post shot, I have been having trouble sleeping. I feel as though I've drank ten cups of coffee and am jittery. I actually quit drinking my one cup of coffee in hopes that it would solve the problem, but it did not. I guess I am not sure if it is the shot or something else."

• leqvi...
• Taken for 6 months to 1 year
• March 21, 2024

For High Cholesterol, Familial Heterozygous "LDL has lowered to the required level. But experienced elevated liver ALTs. Has anyone else observed this? Also, headaches, fatigue, and bowel movements became terrible. Taken 2 doses and won't be taking the third now."