Inclisiran User Reviews & Ratings

• Afr...
• Taken for 1 to 6 months
• April 22, 2023

For High Cholesterol, Familial Heterozygous "Since the first injection, my A1C has spiked to 12.5, and my blood glucose is dangerously high. This has necessitated the prescription of insulin which has a range of serious side effects. While my bad cholesterol level has dropped, there has been no effect on triglycerides. Good cholesterol was in the normal range prior to Leqvio and is holding. Angina, chest pain, and difficulty moving with overall neuralgia are other unwanted symptoms. I am due for a second injection and have reservations."

• Mik...
• Taken for 1 to 2 years
• September 24, 2023

For High Cholesterol "Update to my post on August 2023. 4 weeks after my 4th injection, I was diagnosed with a sterile UTI bladder infection. On top of that, I have had multiple night leg cramps and joint and muscle pains from head to toe. I told the doctor I will not be taking any more injections and I will go back to 5mg Crestor every third day. I can't find any information about how long it takes for Leqvio to get out of the system. Hopefully, I will feel better at the 6-month mark and pray no permanent damage was done. I was so hopeful since I had no initial symptoms, but it was not meant to last."

• Lin...
• Taken for 1 to 6 months
• February 9, 2024

For High Cholesterol "Had first dose. Have been experiencing leg cramps, not severe, wearing support hose helps a lot. The other thing I am experiencing is migraine headaches. Although the shot was given Dec. 14th, the headaches started the week of February 9th. Has anyone had this problem?"

• chu...
• Taken for 1 to 6 months
• September 29, 2023

For High Cholesterol "Leqvio lowered my cholesterol to 128, but the side effects include shortness of breath, diarrhea, weight loss of 28 lbs in 6 months, chest pains, frequent urination, muscle cramps. I could barely walk and had to undergo several tests including a colonoscopy, angiogram, and lung examination. It was determined that all these symptoms were caused by the medication. Doctors have taken me off of Leqvio. It was effective, but I can't tolerate it."

• Hat...
• Taken for less than 1 month
• April 4, 2024

For High Cholesterol "I am on week 3 following the initial dose. Week 1 had minimal side effects: cough, a little sore muscles. Week 2 full-blown Bronchitis, cough, shortness of breath, absolute misery. Week 3 Bronchitis calming down, but now have extreme tiredness. I sleep 8-10 hours and still need a mid-afternoon nap. Before the injection, I'd sleep 6-9 hours and wake up well-rested and full of energy. I hope these side effects go away soon. If not, no more injections for me - Quality of life trumps this 'cure'."

• 194...
• Taken for 1 to 6 months
• August 31, 2024

For High Cholesterol "I have been on this injection for one month, absolutely in agony, painful legs, feet, toes, shoulders, knees, burning skin. Contacted the cardiologist, and his reply was, 'I’ll put you on steroids.' No thanks, was on Repatha for 3 years with no side effects. Wish I’d never had it, not having another. Wondering how long it takes to leave my body."

• K-T...
• Taken for 1 to 6 months
• August 15, 2024

For High Cholesterol "Just had 2nd injection…side effects abound (headache, nausea, muscle weakness and pain, low backache, constipation, ridiculous levels of fatigue, and much more) and never fully dissipated after 1st injection…fully started up again with this injection…all are annoying and affect quality of life…arthritis pain in hands and feet, and cramping in feet, legs, hands are among the worst along with the continual migraine. The medication definitely dramatically lowered my LDL…just not sure I want to continue."

• Man...
• Taken for 1 to 6 months
• January 20, 2025

For High Cholesterol "I took Leqvio because of my high cholesterol. My main health concern besides cholesterol is that I have peripheral neuropathy. I noticed recently that my calves are extremely stiff, and I have pain in my calves. For those reasons, I am considering stopping Leqvio. I will make a decision shortly."

• Ken...
• Taken for 6 months to 1 year
• May 1, 2025

For High Cholesterol "After taking the first shot, I developed great fatigue, which worsened after each additional shot. I was diagnosed with a heart condition by the name of bigeminy. The office that administered the shot was greatly offended that I questioned the shot possibly causing this condition. My heart doctor agreed this was the likely cause. I am 5 months past the third shot and taking no more…ever. The bigeminy is clearing up on its own, thankfully, given further evidence that it was caused by the shot. Planning on reporting it to the FDA when I find the information of where it needs to go."

• Lou...
• March 9, 2023

For High Cholesterol, Familial Heterozygous "After 45 days of use, I have developed severe muscle pain and lower body stiffness, much worse than statin pain. I do not have brain fog, muscle cramps, skin rashes, or other problems I had with statins."

• Doc...
• Taken for 6 months to 1 year
• June 27, 2023

For High Cholesterol, Familial Heterozygous "My cholesterol numbers have dropped specifically Lp(a) has gone down significantly. I like not having to give myself an injection every 2 weeks as I did with Repatha. I have some annoying side effects, however, including a productive cough, UTI's, problems, and sometimes painful urination, and frequently I feel dizzy which is very annoying. I believe that I am losing my hair due to this drug."

• you...
• Taken for 6 months to 1 year
• August 17, 2023

For High Cholesterol, Familial Heterozygous "The real answer is, I don't know. I'm on my 4th injection and haven't noticed side effects. But I have numerous problems with recovery from CABG surgery that could be misunderstood and attributed to this medication. I do have severe leg and calf cramps at times, and I am starting to believe it is Leqvio. In the past, my cramps became so severe I ended up rupturing an Achilles tendon, this was while taking Repatha. I stopped Repatha and the cramps stopped. But recently while taking Leqvio, I started similar cramps, and they can be severe. Now since the med is administered every 6 months, it is hard to stop it and see viable results, no cramps. Not sure what to do at this time."

• She...
• Taken for 2 to 5 years
• October 26, 2024

For High Cholesterol "Two weeks after my first injection, just out of the blue, my right hip started aching. Then it got to where it felt like it was catching and caused a sharp pain, keeping me from walking correctly. X-rays showed arthritis, but it still bothers me. Then my legs started burning, tingling, and hurting, and by the end of the day and when I first get up in the morning, I am so stiff. I’m due for a 5th injection in December, but I’m seriously thinking of canceling it. My cardiologist will probably throw a fit. It has lowered my cholesterol level a lot, but I’m tired of being in such pain just to go grocery shopping."

• Jfo...
• Taken for 1 to 6 months
• September 19, 2023

For High Cholesterol, Familial Heterozygous "Don't know yet if it helped. Switched from Repatha due to cost. After the first dose, LDL was higher, but the doctor said to wait until the second dose to see. I had a bad headache, dizziness, brief shortness of breath, and exhaustion after the first dose. After the second dose, all those effects were repeated (except shortness of breath) but for a longer period, lasting over two weeks. After 6 weeks, I am still experiencing exhaustion and occasional headaches. I think I'm losing my hair and my feet itch like crazy. Is all of this related? I feel like a hypochondriac. I hope the exhaustion is not permanent. I will be going back to Repatha... I will have to find a way to pay for it."

• Mik...
• Taken for 1 to 2 years
• August 19, 2023

For High Cholesterol "Just had my 4th shot. After my second, I had labs drawn and all my numbers dropped by about 40%. HDL, LDL, Trigl, every level is perfect according to my doctor. Very pleased. No side effects at all. So glad because I tried every statin and all caused tremendous pain, especially in joints and feet. Cost covered by Medicare and Supplement. Male age 69."

• Mim...
• Taken for 1 to 2 years
• October 4, 2023

For High Cholesterol "My LDL went from 124 to 54 after the first shot. I have had trouble breathing a few times, which never happened before. But I think it's causing hair loss, and I noticed several people mentioned that, but it's not listed as a side effect. The shot itself is painful for a short while. Wish I knew for sure if it was causing my hair loss."

• Pet...
• Taken for 1 to 2 years
• December 21, 2024

For High Cholesterol "I am having difficulty standing after sitting awhile. Lack of balance and strength to get up. Also, the sudden urge to urinate after sitting. Lose holding control and need to immediately relieve myself. Bladder seems to lose control."

• brr...
• Taken for 1 to 6 months
• May 7, 2024

For High Cholesterol "Week after second dose. So tired, don't want to get up from chair. Stiff leg muscles. Pain in back and hips. The medicine works well, bad cholesterol went from 112 to 43 in one month, 49 after three months. Thankful for that, but side effects are hard to deal with. Questioning the third dose."

• Mlh...
• Taken for 1 to 6 months
• April 23, 2023

For High Cholesterol, Familial Heterozygous "I had my second dose of Leqvio 2 weeks ago. I know it's working because the xanthelasma in the corner of my eye totally disappeared. I came here to give it another great review but noticed the reviews about major muscle pain. I am in extreme pain but thought it was from my fibromyalgia. I am now wondering if it's from the Leqvio? I see my doctor soon and will be asking her. So far, though, this is the only thing that has been working for me. I had that reaction to Repatha, and I hated statins."

• Tom...
• Taken for 1 to 6 months
• February 20, 2024

For High Cholesterol "Soon after taking my first injection, I experienced fatigue lasting several days. I also started seeing blood clots in my urine. I discontinued, but periodic blood clots continue sporadically. Had a cystoscopy and CT that were negative. My gums also started bleeding immediately afterwards. I would think twice about this “new” drug without much of a track record. It did dramatically reduce my numbers, but the bleeding was very concerning."

• Sue...
• Taken for 1 to 6 months
• May 17, 2023

For High Cholesterol, Familial Heterozygous "I have had my first and second doses of Leqvio, and unfortunately, I am having a lot of muscle and joint pain - primarily in my back, neck, and shoulders. It is quite similar to the pain I was having from taking statins, so not sure why that is. It has definitely improved my cholesterol numbers, which is a plus."

• Jos...
• Taken for less than 1 month
• May 15, 2024

For High Cholesterol "After about 4 days: nose bleed, sinusitis, sore lips and tongue. Feeling of exhaustion for a month. After 2 months, developed eczema and psoriasis on shins, and after a further week extremely itchy spots on trunk, arms, and legs. After month 1, cholesterol had reduced from 5.4 to 4.5."

• Cha...
• Taken for 1 to 2 years
• June 22, 2024

For High Cholesterol "After the first injection, my LDL lowered remarkably—well under 50. My libido waned some, but I assumed I would recover as I became more used to the product. After the 3rd injection, about 10 minutes post-injection, while driving, I experienced unusual flushing, my heart rate jumped from less than 70 to 95, my tinnitus increased, breathing felt off but I had a 100% O2 level. My eyes reddened, stomach felt near sick, so I aborted my afternoon schedule and went home. I conferred with the clinic and my cardiologist—most of the symptoms went away after a few hours. So, effective but with troubling side effects. Not sure if I will try another one of those."

• Jun...
• Taken for less than 1 month
• June 16, 2024

For High Cholesterol "I was supposed to start this medication last month but I am scared of this as I was on Repatha because I was told that this could cause impairment of the lungs or sugar. Because I am quite active and wanted to stay like that. When I was put on Repatha I lost an old weight of 1 and a half stone, I am just starting to put on my weight and probably will lose it again. As far as rating this medication, I am unable to do this as I am scared of it, but I am still trying to pluck up the courage to get this, but I wanted to see if I could bring it down myself. Thank you."

• mba...
• June 4, 2025

For High Cholesterol "I started taking Leqvio on my second shot that lasted 6 months. I know I was having intense pain in my lower back that went down the back of my legs, some breathing problems I did not associate with the shot, but by my second shot I knew something was very wrong. My doctor said no, it was not the shot, but I know it is. It was killing me. No more shots for me and hoping it doesn't have long-lasting effects. Please, if you are having this pain, stop the shot."