Hysingla ER and Tiredness: What Users Say

• 3le...
• Taken for less than 1 month
• August 29, 2015

For Pain "30 mg was good, but 40 mg took my pain away, it was heaven. Except that 40 mg made me so tired and drowsy that all I did was sleep. I couldn't function, so that's not acceptable. I would go to bed at 7 pm and wake up at 4 pm the next day! So I'm going back to 30 mg with breakthrough meds. But here is the thing I can't figure out... I take up to 10-15 mg hydrocodone for breakthrough pain ON TOP of my Hysingla ER 30, but that doesn't make me sleepy, it actually kind of keeps me up at night. How bizarre is that? It's the same dosage but reacts completely different. That annoys me because the 40 worked perfectly!!! Except for the severe drowsiness. How can Hysingla ER 40 mg be so much more sedating than Hysingla ER 30 mg with 10-15 mg hydrocodone on top???"

• Sug...
• Taken for less than 1 month
• March 15, 2015

For Pain "Changed from several pills a day to the new Hysingla ER. Was hoping it was something I would like better for just once a day. I do NOT like this medication. You cannot control the peaks due to it being time-released and it's unpredictable. Causes my eyes to feel heavy and hot. You cannot drink at all with this drug, it will cause the medication to be released too quickly, possible overdose. I don't like having no control and I was having breakthrough pain as well."

• sat...
• December 5, 2016

For Pain "I'm having a terrible time with the Hysingla. The 40 mg was so strong I couldn't function. I've been on 30 mg for a week. The headaches, I'm tired all the time, cramping. Overall, I feel like crap. I have nothing for breakout pain but Tylenol. I understand why doctors prescribe this because of abuse, but I have only taken what's prescribed. It's bad enough that I'm actually on a forum complaining."

• ton...
• Taken for 1 to 6 months
• July 20, 2017

For Pain "I have 3 herniated discs, spinal stenosis, and osteoarthritis. I suffer from constant pain every day. I've been on Norco 10/325 4x a day for 3 years now and never abused my medication. A few months ago, my doctor had me try Hysingla ER 40 mg. This medication only lasts about 17 hours and gave me about 30-40% relief with random breakthrough pain. Plus, I felt lethargic the entire day, nauseous, constipated, anxious, and excessive yawning. After putting up with it for two months, I talked with my doctor, and he switched me back to the Norco. So disappointed. I had high hopes for this medication since it was one pill every 24 hours. It just does not work as promised and is expensive."

• Ant...
• August 7, 2018

For Pain "I’ve been suffering from chronic pain for 6 years now due to 3 lumbar herniated discs and osteoarthritis. I’ve been taking Norco 10/325 4 times a day with okay relief. Recently, my doctor had me try Hysingla 40 mg, and honestly, it just doesn’t work! It only lasts about 16-18 hours, and it made me feel very lethargic, anxious, and I would have a lot of breakthrough pain throughout the day, plus it was $413!! My insurance refused to cover it. After talking with my doctor, he switched me to MS Contin. That medication so far has worked so much better than any other extended-release opioid. If you suffer from chronic pain, I recommend you try MS Contin. It works great, and it’s very cheap even without insurance."

• Inj...
• Taken for 1 to 6 months
• June 25, 2017

For Pain "Been on Hysingla for 6 months now; this is my 3rd posting about the experience. I'm using 40 mg ER and have given up. Just too darn tired all the time and 12/24 hours still in back pain, so what the hell, I'm gonna ask the Dr to put me back on 10/325 Percs 4 times daily."

• Anonymous
• Taken for 1 to 6 months
• October 1, 2016

For Pain "Hysingla really keeps the pain level from my fibromyalgia in check. I no longer feel I am on a pain scale roller coaster. I stay around a 3-4 most days. Others sometimes a 6, but no longer am I at an 8-20 on the pain scale. I also love that I don't feel dopey or tired from the Hysingla version like with Norco."

• Mrs...
• Taken for 1 to 6 months
• January 12, 2016

For Pain "24-hour medicine for pain. I only got 6 hours of minimal relief. Started on the 20 mg for 1 month, then Dr. switched me to 40 mg for 1 month, then 30 mg for 1 month. It always seemed to start working long after I took it, about 12 hours, and made me extremely sleepy and tired, along with pain. In the 3 months I took it, I gained 15 pounds without even eating more or differently because I was constantly nauseous with it. Who wants food when queasy? I have been prescribed an instant release pain med and have been on it for 2 days. It works great with no side effects, and I have lost the 7 lbs of the 15 that Hysingla made me gain. Hopefully, the other 8 lbs will come off quickly too because the weight gain from the drug caused my A1C to go"

• Inj...
• Taken for 1 to 6 months
• April 18, 2017

For Pain "This is an update to my posting late Jan. Now, after 4 months of titration, I'm at 40 mg. But disappointed. I could sleep 12 hours each night if allowed to, constantly tired. And taking a new Hysingla pill every 15-18 hours for bleed-through pain. Definitely missing my old four times a day Percs, but I'd be doubling up on those too, I'm sure. So, Dr. says live with it. Pain level at 2. But never any better. And that's disappointing. Dr. won't go higher."

• Anonymous
• Taken for less than 1 month
• November 20, 2017

For Pain "Terrible, did nothing for pain. All I did was sleep and feel lethargic. Pain increased dramatically. I am totally miserable."