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Hydrochlorothiazide / lisinopril User Reviews & Ratings (Page 2)

Brand names: Zestoretic

Hydrochlorothiazide / lisinopril has an average rating of 5.2 out of 10 from a total of 78 reviews on Drugs.com. 32% of reviewers reported a positive experience, while 36% reported a negative experience.

Reviews for Hydrochlorothiazide / lisinopril

Commonly mentioned side effects
  • Mea...
  • Taken for 2 to 5 years
  • September 15, 2020

For High Blood Pressure "I used lisinopril for approx 4 years with no noticeable negative effects. Suddenly, I began having severe nausea and lack of energy. I attributed it to the heat at the time. It didn't appear to make a difference what I ate or drank, it came back up. Then I started to feel dizzy upon standing and noticed an inability to see anything but white fog until the dizziness disappeared. I finally went to the doctor, who did blood work. The next morning, I was given a diagnosis of end-stage renal failure. I was in stage 4. The first thing he did was take me off lisinopril, which he said was the culprit. He then referred me to a nephrologist who confirmed his thought, and he started me on Tekturna. Luckily, and to his astonishment, the kidney disease regressed from stage 4 to stage 2. I am fortunate this drug didn't finish me off, but I now have permanent kidney disease and can't take anything metabolized through the kidney. Avoid this medication at any cost, it is dangerous."

1 / 10
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25 Report
  • Anonymous
  • Taken for less than 1 month
  • June 19, 2012

For High Blood Pressure "Lisinopril 10 for 1 day, plus thyroid medicine and not eating or drinking enough, so I blacked out. Dr. couldn't get blood pressure because it was too low. Pain in shoulders, stuffy nose, hard swallowing, cramp in foot. Dr. said to wait 3-5 days, then start with half dose."

4 / 10
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61 Report
  • FL ...
  • November 16, 2015

Hydrochlorothiazide / lisinopril for High Blood Pressure "I have been taking Zestoretic 20-25 mg along with Norvasc 5 mg for 30 years... brand only as my original doctor prescribed and have never had any more issues with my high blood pressure. The generics released medication more up front than Zestoretic brand, and I would wake up with severe headaches. Zestoretic, along with the Norvasc, was perfect. My blood pressure is normal, and I have no signs of any side effects after all these years... I am now in my 70s. I do have to avoid being out in the hot sun for extended periods of time as it does make me a little dizzy, and I have to drink lots of fluids, but a small price to have my blood pressure under complete control."

10 / 10
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42 Report
  • Anonymous
  • January 25, 2012

For High Blood Pressure "I'm 52, my doctor prescribed 20/12.5 twice a day. I alternate dosages...take twice a day 3 times per week, then one a day the other 4 days. My blood pressure is 104/72. I want to be able to take it only once a day soon! I believe it will happen. What makes this medicine work for me is that I am active by exercising 6 days per week (weight training and cardio 4 days per week, 1 day kickboxing, and 1 day just walking). I believe that if you get plenty of cardio work for heart/blood circulation, it will do what it’s supposed to do without really experiencing all of the bad side effects. The only side effect I experienced is a slight sore throat once in a while."

10 / 10
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54 Report
  • Hig...
  • Taken for less than 1 month
  • September 26, 2015

For High Blood Pressure "I was on lisinopril 10 mg for years and years, but my BP kept going up. On Monday, the doctor started me on lisinopril 20/25 because my BP was 180/110. This okay, the meds Tuesday, Wednesday, and Thursday without problems. Friday, I fainted but thought I was sick. Saturday, I fainted again 1.5 hours after taking the dose. Don't know if I should drop back down to 10 mg for Sunday and Monday, but will be going into the office first thing Monday morning!"

7 / 10
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39 Report

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  • Sic...
  • Taken for 1 to 6 months
  • December 2, 2016

For High Blood Pressure "I started taking Lisinopril October 8th, so almost two months ago. I have developed a dry, hacking cough and I am suffering from horrible charley horse-type leg cramps, which keep me awake at night. It also makes me feel sick if I don't have food in my stomach before taking it. I have changed my diet to vegetarian, cut out drinking any caffeine or alcohol. Hopefully, this will help improve my BP. Going to my doctor next Saturday and I am going to request to be put on something else!"

1 / 10
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36 Report
  • Emm...
  • April 4, 2016

For High Blood Pressure "I was on atenolol for 15 yrs with leg swelling, facial swelling, headaches, joint aches, insomnia, no restful sleep, erratic bp in maybe 1 hr. Switched to lis/hctz 10/12.5 3 yrs ago. The only pill I take. BP steady 125/80. Throat sore, swelling closed, mouth breather, headache 12 hr after taking, tinnitus, dizzy when rising, then began vertigo, real vertigo. Dr said food allergy, stopped lin/hctz for 3 days = BP high, no tinnitus, no dizzy, no headache. 3 days ago had a bleeding floater in left eye. This morning, the ophthalmologist said lin/hctz can affect floater and macular degeneration. Deciding what to do.... lose 50 pounds and get off drug! Or put up with side effects and go blind?"

6 / 10
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39 Report
  • Anonymous
  • November 5, 2009

For High Blood Pressure "I took this medicine for several months. There definitely was a cough, it also affected my sinuses. Then I started developing headaches. I thought it was viral in nature, but this continued on for 2 months. Then my hair started to fall out, and I stopped taking this medicine. It took several days for it to leave my system, and I feel much better without it."

4 / 10
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57 Report
  • TCT...
  • October 7, 2009

Hydrochlorothiazide / lisinopril for High Blood Pressure "Initially, I had to get used to the dizzy feeling after standing up too quickly. I rise slower now. I combat the mild dry mouth and cough by drinking lots of water. The diuretic effect, plus my coffee and water intake in the morning, makes me wish I could move my cubicle into the bathroom. That effect tapers off during the day."

8 / 10
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53 Report
  • Jea...
  • Taken for 5 to 10 years
  • September 1, 2018

For High Blood Pressure "I was on this first about 8-10 years. It did help blood pressure but just a tad. Had daily diarrhea first thing in the morning, ongoing sinus issues (woke up most mornings with a sinus headache), zero tears, etc. After a sudden onset of several eye floaters in one eye, I did some research and stopped taking it. About a week after stopping, I woke up with my eyes oozing thick fluid. I thought my eyes were leaking ocular fluid. It was tears! Eyes floaters considerably lessened after two weeks. Have switched to low-dose Losartan. So far, the only effect I've noticed is a slight headache and sleepiness (so I take it with dinner). However, the last few days, the effects have not occurred at all. Hopefully, Losartan will work better for me."

2 / 10
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29 Report
  • Anonymous
  • August 27, 2009

For High Blood Pressure "I've been on this medicine for 3 months and have experienced no adverse effects. My blood pressure was 180/95 and now stays steady at 126/80. It did take a few days to adjust to it, but overall I find it beneficial."

8 / 10
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52 Report
  • sch...
  • November 7, 2010

For High Blood Pressure "Since starting this medicine a year ago, blood pressure has been a steady 120/70 almost every time. However, I have noticed that if I have a cold, I will get a little light-headed for about 1-3 hours after taking Lisinopril. But not enough of a problem to slow me down much."

9 / 10
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47 Report
  • Anonymous
  • December 12, 2009

For High Blood Pressure "I was recently switched to Lisinopril 20 mg/HCTZ 12.5 mg from Tekturna HCT because my insurance no longer covered the Tekturna. After 2 months of taking nothing, my blood pressure went from 176/104 to 108/68 taking the lisinopril/HCTZ. Very mild side effects, i.e., an occasional cough, but nothing alarming. So, I'm pleased with the switch, although I was very irritated about the insurance company's unwillingness to keep me on the Tekturna HCT, which worked well for me also."

9 / 10
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  • Chr...
  • Taken for 1 to 6 months
  • June 16, 2015

For High Blood Pressure "was taking benazepril 40 mg two times a day. My dad was taking this, so I tried it. Works great. I've found that if I split the dose 20-12.5 in two parts, half in the morning, and half in the evening, it works best. 120/70. No side effects."

10 / 10
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  • Ang...
  • Taken for less than 1 month
  • May 4, 2021

For High Blood Pressure "I just started taking it, and it makes me feel like I have no energy, and it made my reflux act up. I don't like the feeling it is giving me. I'm not going to take it anymore. I'm used to being active, and I can't on this medication, and this medication made me have an upset belly, and I hurt enough without this medication making me hurt worse."

6 / 10
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  • Bam...
  • Taken for 10 years or more
  • March 1, 2017

For High Blood Pressure "I have taken lisinopril HTZ for about 10 years, for the past 3 years, I've had pancreatitis once every year, but for the last 6 months, I have had 3 episodes, and finally, my Dr. looked up side effects, and pancreatitis was indeed one of them. Just in case anyone else is having the same problem. My Dr. switched me to a different BP medication, I feel better with the new meds."

8 / 10
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22 Report
  • Sia...
  • July 21, 2017

For High Blood Pressure "Took myself off of the drug because my BP was at pre-hypertension, and I had this constant dry cough. I used to have horrible leg cramps at night... no matter how much water I drank before bed. I never use salt or eat salty foods; the doctor said to eat more bananas. I never made the connection to the cramps and the meds, and my doctor did not, either. Well... I wondered why I haven't had any leg cramps in months, and my boyfriend said, 'You stopped taking your blood pressure medicine.' Duh!"

1 / 10
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  • Too...
  • Taken for 10 years or more
  • May 7, 2018

For High Blood Pressure "I've taken 10 mg for 20 years. Used to have a (not bothersome) cough; that's gone away. The pharmacist said lisinopril is a very good medicine. My usual BP is 120/75 or so with this dosage. This is the only drug I take; I'm active and my weight is about average. I'm really, really happy with it."

10 / 10
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21 Report
  • Bro...
  • Taken for 5 to 10 years
  • October 27, 2016

For High Blood Pressure "Every day when I take it, I feel sick, lightheaded, dizzy, my stomach knots up, and it is awful pain. I have to lay down for a while to get over it, and after reading all of the reviews on lisinopril, I'm wondering if it hasn't been side effects all along since I've been taking the medication."

2 / 10
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25 Report
  • moo...
  • Taken for 1 to 2 years
  • December 28, 2020

For High Blood Pressure "I have been on lisinopril 20 mg for over a year now. It worked at first in lowering my blood pressure. It went from 155/99 down to about 135/80-not too bad-but my BP went back up, and so we added hydrochlorothiazide, and it dropped... a lot. Within 3 days it was at 125/87. So far no side effects, but I have noticed an increase in muscle cramps, charley horse-painful ones. Not sure what to do about the cramping. I'll do some research and see if I need to eat something that will reduce the cramping. My doctor does test me frequently for kidney function, but so far no negative effects on my kidneys."

9 / 10
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  • swe...
  • Taken for 5 to 10 years
  • April 24, 2025

For High Blood Pressure "This drug works well for controlling my blood pressure. If I do anything physically exerting, I get muscle cramps in various locations like legs, arms, fingers. The only way to stop these cramps is to take an electrolyte drink, like Liquid IV, Powerade, Gatorade, etc. These electrolyte drinks can get rid of the cramps within 15-20 minutes. However, they contain salts, which works against the lisinopril/HCTZ. In my case, the increase in blood pressure from these drinks is very small. It may not be so small for others. My doctor is aware of this and told me I can use these drinks, but not excessively. I hope this helps others facing severe muscle cramps associated with this medication."

8 / 10
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  • Tru...
  • Taken for 1 to 6 months
  • May 26, 2020

For High Blood Pressure "I started on this medication because my blood pressure was still high even on amlodipine 5 mg. It lowered my blood pressure significantly from the 150s to the 120s, but the side effects are painful. I have aching pain on the left side of my chest, plus a cough, as well as some dizziness when I lay down on my right side. I had to cut my pill in half to minimize these effects, but I will let the doctor know on my next visit. I would like to stop it altogether, but I worry about rebound hypertension."

7 / 10
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11 Report
  • Ms ...
  • September 8, 2017

For High Blood Pressure "I have been taking 20 mg lisinopril for about a month, and it has been somewhat of a nightmare. It is effective at lowering my diastolic BP, which is good, but I'm also trying to eat foods that would help with my blood pressure that contain potassium, and that's where the nightmare begins. I wasn't feeling well, and I noticed a lot of discomfort after I ate bananas. Because lisinopril works by causing the body to retain potassium, my eating potassium-rich foods is apparently a negative, which doesn't make sense if I'm trying to eat better to lower my blood pressure. I now see why people wind up taking these meds for the rest of their lives. I'm going to stop taking it because of this effect on me."

2 / 10
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19 Report
  • Tin...
  • April 15, 2021

For High Blood Pressure "I'm 61 years old and have been taking lisinopril/hydrochlorothiazide (20 mg/25 mg) for over 10 years for high blood pressure. Over the last 3 years, I developed symptoms of neuropathy in both feet, and in the last several months, irregular heartbeat, spikes in blood pressure, and near-constant headaches. I was recently evaluated for vascular problems in my feet and lower legs; this was ruled out. However, my foot pain is constant, and sometimes it results in shooting pains up to my knees. For an unknown reason, this foot pain often increases right after a meal. I am to undergo heart 'stress tests' to be followed with some sort of nerve tests in both feet. If these other tests do not point to any known cause, I will ask my doctor to switch me to another blood pressure medication."

5 / 10
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9 Report
  • Not...
  • Taken for less than 1 month
  • August 18, 2021

For High Blood Pressure "Had adverse effects after first pill of 10/12.5 about an hour after first dosage, chest pain/discomfort, tachycardia, pain in big toe. I took it @ 9 a.m., waiting for it to leave my system. It is a horrible feeling, so I won't take it again."

1 / 10
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7 Report

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